anti-UBR5 (UBR5) Antikörper

Bezeichnung:: anti-Ubiquitin Protein Ligase E3 Component N-Recognin 5 Antikörper (UBR5)

Auf www.antikoerper-online.de finden Sie aktuell 84 Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) Antikörper von 18 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen UBR5 Kits (2) und und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 93 UBR5 Produkte verfügbar.

Synonyme:: 4432411E13Rik, AW549941, C77315, D030042K14, Dd5, Edd, Edd1, HYD, mKIAA0896, Rat100

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	UBR5	51366	O95071
	UBR5	70790	Q80TP3
	UBR5	117060
Alle Spezies anzeigen Weitere Synonyme anzeigen

Meistgesuchte Reaktivitäten zu anti-UBR5 (UBR5) Antikörper

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anti-Human UBR5 Antikörper:

anti-Mouse (Murine) UBR5 Antikörper:

anti-Rat (Rattus) UBR5 Antikörper:

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Verknüpfte Pathways mit anti-UBR5 Antikörper

Intracellular Steroid Hormone Receptor Signaling Pathway

Weitere Produktkategorien zu UBR5 Antikörper

Am meisten referenzierte anti-UBR5 Antikörper

Human Polyclonal UBR5 Primary Antibody für ICC, IF - ABIN151138 : Nash, Chen, Salganik, Muzyczka: Identification of cellular proteins that interact with the adeno-associated virus rep protein. in Journal of virology 2008 (PubMed)
Show all 7 Pubmed References
Human Polyclonal UBR5 Primary Antibody für IHC (p), IHC - ABIN249850 : Garbow, Doherty, Schugar, Travers, Weber, Wentz, Ezenwajiaku, Cotter, Brunt, Crawford: Hepatic steatosis, inflammation, and ER stress in mice maintained long term on a very low-carbohydrate ketogenic diet. in American journal of physiology. Gastrointestinal and liver physiology 2011 (PubMed)
Show all 2 Pubmed References

Weitere Antikörper gegen UBR5 Interaktionspartner

Human Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) Interaktionspartner

BMI1 (zeige BMI1 Antikörper) and UBR5 repress the polymerase II (zeige POLR2F Antikörper) (Pol II (zeige 0 Antikörper))-mediated transcription at damaged sites
Results found that EDD was consistent with GOLPH3 (zeige GOLPH3 Antikörper) expression and also promoted the EMT (zeige ITK Antikörper) process and activated Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling in epithelial ovarian cancer.
UBR5 directly binds to the tumor suppressor esophageal cancer-related gene 4, increasing its ubiquitination to reducing the protein stability of ECRG4 (zeige C2orf40 Antikörper) to promote colorectal cancer progression.
Wnt (zeige WNT2 Antikörper)-dependent inactivation of the Groucho/TLE co-repressor by the HECT E3 ubiquitin ligase (zeige MUL1 Antikörper) Hyd/UBR5 is a key prerequisite that enables Armadillo/beta-catenin to activate transcription.
UBR5 downregulates proapoptotic MOAP-1 (zeige MOAP1 Antikörper) and suggest that UBR5 can confer cisplatin resistance in ovarian cancer.
Data suggest that UBR5 down-regulates levels of TRAF3 (zeige TRAF3 Antikörper), a key component of Toll (zeige TLR4 Antikörper)-like receptor signaling, via the miRNA pathway; p90RSK (zeige RPS6KA1 Antikörper) is an upstream regulator of UBR5; p90RSK (zeige RPS6KA1 Antikörper) phosphorylates UBR5 as required for translational repression of TRAF3 (zeige TRAF3 Antikörper) mRNA. (UBR5 = ubiquitin protein ligase E3 component n-recognin 5 protein; TRAF3 (zeige TRAF3 Antikörper) = TNF receptor-associated factor 3 (zeige TRAF3 Antikörper); p90RSK (zeige RPS6KA1 Antikörper) = 90 kDa ribosomal protein S6 (zeige RPS6 Antikörper) kinase (zeige RPS6KB1 Antikörper))
Data show that ubiquitin protein ligase E3 component n-recognin 5 protein (UBR5) bound the tumor suppressor gastrokine 1 (GKN1 (zeige GKN1 Antikörper)) and increased its ubiquitination to reduce the protein stability of GKN1 (zeige GKN1 Antikörper).
Findings unveil UBR5 as a novel and critical regulator of tumor growth, metastasis, and immune response in triple negative breast cancer.
Study highlights many functional biological role of UBR5 especially in cancer where it seems to be a key regulator of cell signaling. [review]
Colony-formation assays and soft agar assays show that gain of function of TIP60 or depletion of EDD1 in HPV-positive cervical cancer cells significantly inhibits cell growth in vitro

Mouse (Murine) Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) Interaktionspartner

Hence, while loss of UBR5 perturbed Hedgehog (zeige SHH Antikörper) signalling in the developing limb, there were no obvious morphological defects.
Findings unveil UBR5 as a novel and critical regulator of tumor growth, metastasis, and immune response in triple negative breast cancer.
UBR5-mediated ATMIN (zeige ATMIN Antikörper) ubiquitination is a vital event for ATM (zeige ATM Antikörper) pathway selection and activation in response to DNA damage
a novel function of RIP1 (zeige RALBP1 Antikörper) kinase involving its interaction with EDD to regulate JNK (zeige MAPK8 Antikörper) activation and TNFalpha (zeige TNF Antikörper) production.
Silencing Edd1 with shRNA in mouse embryonic stem cells significantly suppressed their growth.
The SCF (zeige KITLG Antikörper) E3 ligase complex containing Fbxo40 (zeige FBXO40 Antikörper) directly ubiquitinates IRS1 (zeige IRS1 Antikörper), and this activity is enhanced by increased tyrosine phosphorylation of IRS1 (zeige IRS1 Antikörper).
Through the PABC domain, EDD participates in miRNA silencing by recruiting downstream effectors.
UBR5 can attenuate myocardin (zeige MYOCD Antikörper) protein degradation resulting in increased myocardin (zeige MYOCD Antikörper) protein expression without affecting myocardin (zeige MYOCD Antikörper) mRNA expression.
Results suggest that Edd has an essential role in extraembryonic development.

UBR5 Antigen-Profil

Beschreibung des Gens

This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.

Alternative names and synonyms associated with UBR5

ubiquitin protein ligase E3 component n-recognin 5 (UBR5) Antikörper
ubiquitin protein ligase E3 component n-recognin 5 (Ubr5) Antikörper

4432411E13Rik Antikörper
AW549941 Antikörper
C77315 Antikörper
D030042K14 Antikörper
Dd5 Antikörper
Edd Antikörper
Edd1 Antikörper
HYD Antikörper
mKIAA0896 Antikörper
Rat100 Antikörper

Bezeichner auf Proteinebene für UBR5

E3 identified by differential display , E3 ubiquitin protein ligase, HECT domain containing, 1 , E3 ubiquitin-protein ligase UBR5 , E3 ubiquitin-protein ligase, HECT domain-containing 1 , hHYD , hyperplastic discs protein homolog , progestin induced protein , progestin-induced protein , ubiquitin-protein ligase , extraembryonic development

GENE ID	SPEZIES
51366	Homo sapiens
70790	Mus musculus
117060	Rattus norvegicus
420252	Gallus gallus
475055	Canis lupus familiaris
100157625	Sus scrofa

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Show all anti-Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) Antikörper with Pubmed References

Human Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) Interaktionspartner

Mouse (Murine) Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) Interaktionspartner

Beschreibung des Gens

Alternative names and synonyms associated with UBR5

Bezeichner auf Proteinebene für UBR5