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Human Monoclonal NKX3-1 Primary Antibody für FACS, IHC - ABIN969316
Jiang, Yu, Zhang, Chen, Liu, Hu, Zhang: p53 overexpression represses androgen-mediated induction of NKX3.1 in a prostate cancer cell line. in Experimental & molecular medicine 2007
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Mouse (Murine) Monoclonal NKX3-1 Primary Antibody für IHC (fro), IHC (p) - ABIN151338
Kim, Cardiff, Desai, Banach-Petrosky, Parsons, Shen, Abate-Shen: Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis. in Proceedings of the National Academy of Sciences of the United States of America 2002
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Human Monoclonal NKX3-1 Primary Antibody für ELISA, FACS - ABIN4340059
Zhang, Fillmore, Zimmer: Structural and functional analysis of domains mediating interaction between the bagpipe homologue, Nkx3.1 and serum response factor. in Experimental biology and medicine (Maywood, N.J.) 2008
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During prostate cancer initiation, Nkx3.1 expression is frequently lost in both humans and mouse models. Data, including data from studies using cells from transgenic mice, suggest that androgens activate Nkx3.1 transcription via androgen receptor (zeige AR Antikörper) binding to 11-kb region in both normal luminal cells and castration-resistant prostatic neoplasm cells via androgen response elements in Nkx3.1 3prime untranslated region.
study demonstrated that expression of homeobox protein NK-3 homolog A(Nkx3.1) influenced both the timing and magnitude of the DNA damage response in the mouse prostate
Nkx3.1 loss and Tmprss2 (zeige TMPRSS2 Antikörper)-ERG (zeige ERG Antikörper) upregulation do not cooperate to enhance prostate tumorigenesis in vivo.
Id4 regulates NKX3.1, Sox9 and PTEN.
activated canonical Wnt (zeige WNT2 Antikörper) signals and Nkx3.1 function in a positive feedback loop to regulate prostate bud growth and luminal epithelial differentiation.
multiple NKX3.1 binding sites were found in the RAMP1 (zeige RAMP1 Antikörper) locus in human prostate cancer cells and in the normal mouse prostate.
Deletions of Klf5 (zeige KLF5 Antikörper) and Nkx3-1 do not have a additive effect in prostatic carcinogenesis in mouse model.
Transcriptional activation of prostate specific homeobox (zeige PRRX1 Antikörper) gene NKX3-1 in subsets of T-cell lymphoblastic leukemia (T-ALL).
Androgen-dependent transcription of the mouse Nkx3.1 gene is conferred through a noncanonical element within the intron of the gene.
Nkx3.1 has a role in bacterial prostatitis and its progression to inflammation and neoplasia
Low NKX3.1 expression is associated with hepatocellular carcinoma.
With deletion mutation analysis, plasmid construction, EMSA and oligonucleotide decoy technique, two Sp1 (zeige PSG1 Antikörper)-elements which located between +29 to +43 and -60 to -46 of NKX3.1 gene were identified and proven to be functional elements.
The androgen-regulated homeodomain transcription factor NKX3.1 plays roles in early prostate development and functions as a prostate-specific tumor suppressor.
the association between the down-regulation of PTEN and NKX3.1 genes contributed to prostate tumorigenesis.
NKX3.1 and DYRK1B (zeige DYRK1B Antikörper) were shown to interact via the DYRK1B (zeige DYRK1B Antikörper) kinase domain. In vitro kinase assay showed that DYRK1B (zeige DYRK1B Antikörper) phosphorylated NKX3.1 at serine 185, a residue critical for NKX3.1 steady-state turnover.
An NKX3.1 binding site polymorphism in the l-plastin (zeige LCP1 Antikörper) promoter leads to differential gene expression in human prostate cancer
Analysis of prostate cancer tissues showed that the presence of a TMPRSS2 (zeige TMPRSS2 Antikörper)-ERG (zeige ERG Antikörper) rearrangement was highly correlated with lower levels of NKX3.1 expression consistent with the role of NKX3.1 as a suppressor of the pathogenic gene rearrangement.
NKX3.1 expression mediate beta-catenin (zeige CTNNB1 Antikörper) and E-cadherin (zeige CDH1 Antikörper) association and cell migration in prostate cells.
Our results indicate that variation in NKX3.1 expression combined with selenium or vitamin E treatment modifies the risk of prostate cancer.
This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene.
NK3 transcription factor related, locus 1
, NK3 homeobox 1
, Drosophila NK-3 transcription factor, locus 1
, homeobox protein NK-3 homolog A
, homeobox protein Nkx-3.1
, NK homeobox, family 3, A
, NK3 transcription factor homolog A
, NK-3 transcription factor, locus 1