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Human Monoclonal NCOA1 Primary Antibody für ChIP, IF - ABIN152353
Klinge, Jernigan, Mattingly, Risinger, Zhang: Estrogen response element-dependent regulation of transcriptional activation of estrogen receptors alpha and beta by coactivators and corepressors. in Journal of molecular endocrinology 2004
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Amphibian Polyclonal NCOA1 Primary Antibody für FACS, ICC - ABIN152700
Rogatsky, Zarember, Yamamoto: Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones. in The EMBO journal 2001
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Human Polyclonal NCOA1 Primary Antibody für WB - ABIN151779
Heemers, Regan, Schmidt, Anderson, Ballman, Tindall: Androgen modulation of coregulator expression in prostate cancer cells. in Molecular endocrinology (Baltimore, Md.) 2009
Our findings directly associate the AR/NCOA1 complex with PRKD1 (zeige PRKD1 Antikörper) regulation and cellular migration and support the concept of therapeutic inhibition of NCOA1 in prostate cancer.
SRC-1 (zeige SRC Antikörper) can impact osteoblast function in an estrogen receptor (zeige ESR1 Antikörper)-independent manner.
The pregnane X receptor (zeige NR1I2 Antikörper) down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 (zeige SRC Antikörper) coactivator.
miR (zeige MLXIP Antikörper)-4443 acts in a tumor-suppressive manner by down-regulating TRAF4 (zeige TRAF4 Antikörper) and NCOA1 downstream of MEK (zeige MAP2K1 Antikörper)-C/EBP (zeige CEBPA Antikörper)-mediated leptin (zeige LEP Antikörper) and insulin (zeige INS Antikörper) signaling, and that insulin (zeige INS Antikörper) and/or leptin (zeige LEP Antikörper) resistance (e.g. in obesity) may suppress this pathway and increase the risk of metastatic CRC (zeige CALR Antikörper).
Results provide the first evidence that NCOA1 is a direct target of miR (zeige MLXIP Antikörper)-105-1 suggesting that NCOA1 and miR (zeige MLXIP Antikörper)-105-1 may have potential prognostic value and may be useful as tumor biomarkers for the diagnosis of HCC (zeige FAM126A Antikörper) patients.
Data suggest that steroid receptor (zeige ESR2 Antikörper) coactivators (NCOA1, NCOA2 (zeige NCOA2 Antikörper), NCOA3 (zeige NCOA3 Antikörper)) are over-expressed in a number of hormone-dependent cancers where they promote tumor growth, invasion, metastasis, and chemo-resistance; with their multiple roles in cancer, steroid receptor (zeige ESR2 Antikörper) coactivators are promising targets for development of antineoplastic agents that can interfere with their function. [REVIEW]
The mechanism of IL-6-induced AR activation is mediated through enhancing AR-SRC-1 interaction and inhibiting AR-SMRT interaction.
IL-6-mediated AR antagonism induced by cypermethrin is related to repress the recruitment of co-regulators SRC-1 and SMRT to the AR in a ligand-independent manner
NCOA1 potentiates breast cancer angiogenesis through upregulating HIF1alpha (zeige HIF1A Antikörper) and AP-1 (zeige FOSB Antikörper)-mediated VEGFa (zeige VEGFA Antikörper) expression
miR (zeige MLXIP Antikörper)-137 has a role in targeting p160 (zeige MSH6 Antikörper) steroid receptor (zeige ESR2 Antikörper) coactivators SRC1 (zeige SRC Antikörper), SRC2 (zeige NCOA2 Antikörper), and SRC3 (zeige NCOA3 Antikörper) and inhibits cell proliferation
Although the SRC-1 expression in female mice was lower than that in males under normal conditions, its expression in females was more dominant after spinal cord injury. The expression of Profilin-1 (zeige PFN1 Antikörper) in both sexes increased first, and then decreased at 3 days after injury. However, there was a second increase in females at 7 days after injury.
SRC-1 can impact osteoblast function in an estrogen receptor (zeige ESR1 Antikörper)-independent manner.
The results suggest that biochanin A activates RORgamma-dependent IL-17 (zeige IL17A Antikörper) transcription through the enhancement of STAT3 (zeige STAT3 Antikörper) phosphorylation and STAT3 (zeige STAT3 Antikörper)-mediated recruitment of NCOA1 to RORgamma.
ubiquitination of K446 limits RORgammat-mediated Th17 differentiation by inhibiting the recruitment of coactivator SRC1
Loss of SRC-1 is associated with high Blood Pressure and Aortic Stiffness.
local E2 inhibition could induce aberrant actin polymerization and also showed an important role of SRC-1 in the mediation of local E2 action on hippocampal synaptic plasticity by regulation of actin cytoskeleton dynamics
SRC-1/3 are required for cardiomyocyte proliferation and differentiation at earlier developmental stages, and their dysfunction causes NCC (zeige SLC12A3 Antikörper)-like abnormalities in the hearts of newborn and adult mice.
While hippocampal SRC-1 was significantly downregulated by orchidectomy (ORX), its expression was rescued by treatment with testosterone in a dose-dependent manner. Testosterone regulates synaptic proteins involves AR, estrogen receptors and SRC-1.
fetal lungs produce signals to initiate labor when mature, and SRC-1/-2-dependent production of SP-A (zeige SFTPA1 Antikörper) and PAF (zeige PAF Antikörper) is crucial for this process
Consequently, SRC-1 null mice displayed low TAT (zeige TAT Antikörper) expression and presented with hypertyrosinemia and corneal alterations, 2 clinical features observed in the human syndrome of TAT (zeige TAT Antikörper) deficiency.
we cloned and sequenced full length cDNA of NCOA-1 gene in pig. The putative protein includes 1440 amino acids. Sequences alignment showed that pig NCOA-1 gene cDNA sequence has identity of 93.73% with human and mouse.
The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified.
, PAX3/NCOA1 fusion protein
, class E basic helix-loop-helix protein 74
, renal carcinoma antigen NY-REN-52
, steroid receptor coactivator-1
, nuclear receptor coactivator 1
, steroid receptor coactivator 1
, nuclear receptor coactivator protein 1