-
Sumoylation of RORgammaT regulates TH17 differentiation and thymocyte development via histone acetyltransferase KAT2A, which stabilizes the binding of SRC1 to enhance RORgammaT transcription factor activity.
-
Although the SRC-1 expression in female mice was lower than that in males under normal conditions, its expression in females was more dominant after spinal cord injury. The expression of Profilin-1 in both sexes increased first, and then decreased at 3 days after injury. However, there was a second increase in females at 7 days after injury.
-
SRC-1 can impact osteoblast function in an estrogen receptor-independent manner.
-
The results suggest that biochanin A activates RORgamma-dependent IL-17 transcription through the enhancement of STAT3 phosphorylation and STAT3-mediated recruitment of NCOA1 to RORgamma.
-
ubiquitination of K446 limits RORgammat-mediated Th17 differentiation by inhibiting the recruitment of coactivator SRC1
-
Loss of SRC-1 is associated with high Blood Pressure and Aortic Stiffness.
-
local E2 inhibition could induce aberrant actin polymerization and also showed an important role of SRC-1 in the mediation of local E2 action on hippocampal synaptic plasticity by regulation of actin cytoskeleton dynamics
-
SRC-1/3 are required for cardiomyocyte proliferation and differentiation at earlier developmental stages, and their dysfunction causes NCC-like abnormalities in the hearts of newborn and adult mice.
-
While hippocampal SRC-1 was significantly downregulated by orchidectomy (ORX), its expression was rescued by treatment with testosterone in a dose-dependent manner. Testosterone regulates synaptic proteins involves AR, estrogen receptors and SRC-1.
-
fetal lungs produce signals to initiate labor when mature, and SRC-1/-2-dependent production of SP-A and PAF is crucial for this process
-
Consequently, SRC-1 null mice displayed low TAT expression and presented with hypertyrosinemia and corneal alterations, 2 clinical features observed in the human syndrome of TAT deficiency.
-
the effect of orchidectomy (ORX) on the expression of SRC-1
-
Letrozole induces dramatic decrease of SRC-1 in the medial septal, hippocampus, medial habenular nucleus, arcuate hypothalamic nucleus and superior colliculus.
-
SRC1 regulates anxiety responses in male and female mice.
-
IRS1 levels are significantly increased in mouse cell lines representing fat and muscle lineages with p/CIP and SRC-1 deletions and in white adipose tissue and skeletal muscle of knockout mice.
-
The effects of gonadectomy on the expression of SRC-1 suggest a distinct regulatory mode between female and male gonad hormones in the regulation of hippocampal SRC-1 protein.
-
A previously unidentified 70-kDa SRC-1 proteolytic isoform is highly elevated both in the endometriotic tissue of mice with endometriosis and in endometriotic stromal cells biopsied from patients with endometriosis.
-
Daidzein increases protein level of SRC-1 in cultured osteoblasts.
-
Localization and sex-difference of steroid receptor coactivator-1 immunoreactivities in the brain of adult female and male mice.
-
SRC-1 plays key roles in MMTV-neu mediated mammary tumorigenesis and response to anti-proliferative PPAR ligands.
