anti-FOXA1 (FOXA1) Antikörper

Human Forkhead Box A1 (FOXA1) Interaktionspartner

1. FOXA1 is a master factor in controlling the TGF-beta-stimulated transcriptome and a regulator of TGF-beta biological functions in nasopharyngeal carcinoma oncogenesis.

2. FOXA1 mutations alter its pioneering function and perturb normal luminal epithelial differentiation programs, providing further support for the role of lineage plasticity in prostate cancer progression

3. description of central role of FOXA1 in mediating oncogenesis driven by the androgen receptor, and mechanistic insights into how the classes of FOXA1 alteration promote the initiation and/or metastatic progression of prostate cancer; results have direct implications for understanding the pathobiology of other hormone-receptor-driven cancers and rationalize the co-targeting of FOXA1 activity in therapeutic strategies

4. Study find that FOXA1 is an important mediator of proliferative and antiapoptotic activities in human colorectal cancer cells. FOXA1 was upregulated in human colorectal cancer tissues and was associated with poor prognosis, suggesting an oncogenic role of FOXA1 in the development and progression of human colorectal cancer.

5. FOXA1 is expressed in more than 50% of ER+ breast cancers. Similar studies show that FOXA1 is required for estrogen-induced re-entry into the cell cycle

6. AR + /FOXA1 + expression defines a luminal-like TNBC subgroup affected with a worse outcome compared to other TNBC and a higher risk of late recurrences. This subgroup appears enriched in PIK3CA mutations, suggesting a role for PI3K inhibitors in this subgroup.

7. FOXA1 promoted proliferation, migration, invasion, and decreased chemosensitivity of gastric cancer cells to 5-Fu treatment through transcriptional activator KRT7

8. a compact palindromic DNA element (termed 'DIV' for its diverging half-sites) induces the homodimerization of FOXA1 with strongly positive cooperativity. Collectively, the DIV guides chromatin engagement and regulation by FOXA1 and its perturbation could be linked to disease etiologies.

9. the functional genetic variant rs4442975 (FOXA1)was associated with bone marrow suppression during neoadjuvant chemotherapy for luminal A type breast cancer. These results may help establish reliable molecular markers for predicting the prognosis of personalized treatment for luminal A type breast cancer and thereby contribute to the development of appropriate therapies.

10. CK7 expression is an independent prognostic factor for esophageal squamous cell carcinoma, and FOXA1 is a non-independent prognostic factor.

11. FOXA1 was expressed mostly in ER-positive breast cancer metastases. Expression of Nestin was related to triple-negative metastases, where brain was the most frequent metastatic site. These findings highlight the clinical utility of FOXA1 and Nestin expression and warrant their inclusion in routine immunohistochemical panels for breast carcinoma.

12. Circular RNA MCM3AP-AS1 directly bound to miR-194-5p and acted as competing endogenous RNA while subsequently facilitating miR-194-5p target gene FOXA1 expression in hepatocellular carcinoma cells.

13. Here we identify the transcription factor ONECUT2 (OC2) as a master regulator of AR networks in metastatic castration-resistant prostate cancer (mCRPC). OC2 acts as a survival factor in mCRPC models, suppresses the AR transcriptional program by direct regulation of AR target genes and the AR licensing factor FOXA1, and activates genes associated with neural differentiation and progression to lethal disease.

14. the expression level of miR-132 was decreased in thyroid cancer tissues and cell lines and that miR-132 inhibited cell proliferation, migration, and invasion of thyroid cancer by repressing FOXA1.

15. these results provide a mechanism for how interdependent FoxO1:FoxA1/2 binding is negatively impacted by insulin and provide a developmental context for cooperative gene activation by these factors.

16. Mammary Paget's disease and extramammary (EMPD) share dysregulation of the glandular developmental regulator gene FOXA1

17. FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer.

18. We show that MSK1 downregulation impairs the differentiation of breast cancer cells, increasing their bone homing and growth capacities. MSK1 controls the expression of genes required for luminal cell differentiation, including the GATA3 and FOXA1 transcription factors, by modulating their promoter chromatin status.

19. The cell cycle control kinase CDK1 might control directly FOXA1 by phosphorylation and other kinases indirectly by means of regulating other proteins.

20. The unexpected signature for estradiol-induced program resides in indirect recruitment of ERa to a large cohort of basally active FOXA1-bound enhancers that lack cognate ERa DNA-binding elements.

Mouse (Murine) Forkhead Box A1 (FOXA1) Interaktionspartner

1. Foxa1 and Foxa2 in thymic epithelial cells (TEC) regulate medullary TEC and regulatory T-cell maturation.

2. FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer.

3. we propose a model in which deletion of Foxa1 from STN neurons evokes a compromised state of the STN, evident by the reduced firing activity of STN neurons and the loss of a significant fraction of STN neurons.

4. this model system will facilitate further in vivo functional studies of Foxa1 or other factors in mammary gland development and tumor formation and progression

5. Loss of Interdependent Binding by the FoxO1 and FoxA1/A2 Forkhead Transcription Factors Culminates in Perturbation of Active Chromatin Marks and Binding of Transcriptional Regulators at Insulin-sensitive Genes.

6. FoxA1, FoxA2, and LIPG control the uptake of extracellular lipids for breast cancer growth.

7. genome-wide binding sites of the forkhead/winged helix transcription factor Foxa1, which functions redundantly with Foxa2 to regulate the differentiation of midbrain dopamine neurons, were characterized.

8. Disruption of Shp in mice alters timing of expression of genes that regulate homocysteine metabolism and the liver responses to ethanol and homocysteine. SHP inhibits the transcriptional activation of Bhmt and cystathionine gamma-lyase by FOXA1.

9. ChIP-exonuclease of the ER pioneer factor FoxA1 identifies protected DNA with a predictable 8 bp overhang from the Forkhead motif, which authors term mesas; showed that mesas occur in multiple cellular contexts and exist as single or overlapping motifs.

10. TIP30 is a key regulator for maintaining ER(+) and ER(-)luminal pools in the mammary luminal lineage via FoxA1.

11. Mechanistically, JARID1B was required for GATA3 recruitment to the Foxa1 promoter to activate Foxa1 expression.

12. Foxa1 recruited Grg3 to the Nanog promoter -2kb upstream region and switched the promoter to an inactive chromatin status represented by typical modifications in histone H3.

13. Results indicate Foxa1 expression is required for the maintenance of prostatic cellular differentiation.

14. FoxA1 is a lineage-specification factor that is induced by IFN-beta and supports the differentiation and suppressive function of FoxA1(+) Treg cells

15. Results suggest that the downregulation of miR-17 expression could lead to FoxA1 overexpression in acute lung injury (ALI).

16. FoxA1 defines prostate-specific androgen receptor recruitment. It is constitutively bound to chromatin and guides AR to specific genomic loci upon hormone exposure.

17. Foxa1 and Foxa2 are required for formation of the intervertebral discs.

18. This study demonistrated that the later role for Foxa genes in regulating the maintenance of dopaminergic phenotype in mDA neurons.

19. Foxa1 and Foxa2, while redundant during development, have evolved divergent roles in the adult liver, ensuring the maintenance of both genes during evolution.

20. Stable expression of FoxA1 promotes pluripotent P19 embryonal carcinoma cells to be neural stem-like cells.