anti-Integrin beta 4 (ITGB4) Antikörper

Mouse (Murine) Integrin beta 4 (ITGB4) Interaktionspartner

1. Expression of the beta 4 subunit of the alpha 6 beta 4 integrin induces monocytic differentiation of 32D/v-Abl transformed cells. alpha 6 beta 4 integrin promotes growth arrest and differentiation by modulating Abl kinases and p73 protein pathway(s).

2. These data indicate that integrin alpha6beta4 and PMP22 cooperate to organize the internode and to allow proper propagation of the axonal signal along the axons.

3. ITGB4 deficiency leads to severe allergy-induced airway inflammation and airway hyper-responsiveness.

4. The results of this study suggested that ITGB4 knockout induced chronic inflammation mediated the comorbidity of asthma and bipolar disorder.

5. he potential effect of Ntn-1 on angiogenesis is further verified by the mouse hindlimb ischemia model, where the pre-activation of hUCB-MSCs with Ntn-1 significantly improved vascular regeneration. These results demonstrate that Ntn-1 plays an important role in the tissue regeneration process of hUCB-MSC via the lipid raft-mediated Inalpha6beta4 signaling pathway.

6. MARVELD1 mediated the invasion of trophoblast cells via regulation of the expression of integrin beta4 during placenta development.

7. Integrin beta4 contributes to mammary gland development by sustaining PTHrP expression and enabling PTHrP signaling.

8. keratins have a role in controlling beta4-integrin endocytosis involving a plectin-Erk1/2-dependent mechanism relevant for epidermal differentiation and pathogenesis

9. Up-regulation of integrin beta4 and TRPV1 in migrating keratinocytes.

10. Ectopic induction of Nur77 in endothelial cells is sufficient to improve skin wound healing. Furthermore, TR3/Nur77 regulates the expression of integrin beta4 by targeting its promoter activity.

11. Col17a1/ keratinocytes exhibited increased spreading on laminin 332 and accelerated, but less directed cell motility. These effects were accompanied by increased expression of the integrin subunits beta4 and beta1.

12. Both annexin A7 and integrin beta4 were essential for small molecule, 6-amino-2, 3-dihydro-3-hydroxymethyl-1, 4-benzoxazine-induced autophagy.

13. Findings indicate a function for Id2 in regulating Snai1-mediated repression of integrin beta4.

14. Lack of endothelial beta4 integrin had no effect on vascular development, integrity, or endothelial proliferation

15. Targeted deletion of the signaling domain of beta4 inhibited prostate tumor growth and progression in response to loss of p53 and Rb function in a model of prostate cancer (PB-TAg mice).

16. Deficiency of integrin alpha(6)beta(4) is modestly but significantly suppressed reporter-gene transduction by papillomaviruses in conditional integrin beta(4) knockout mice.

17. aberrant expression of alpha6beta4 integrin in post-mitotic epidermal keratinocytes stimulates a pro-tumorigenic skin microenvironment

18. The expression of beta4 integrin in interstitial, vessel-associated cells with myogenic activity within adult skeletal muscle.

19. Data show that beta4 integrin associates with MMP9 and that its ectodomain is a target for cleavage by MMP9 in vivo under pathological conditions.

20. Integrin beta4 signaling promotes mammary tumor cell adhesion to brain microvascular endothelium by inducing ErbB2-mediated secretion of VEGF

Human Integrin beta 4 (ITGB4) Interaktionspartner

1. beta1 and beta4 integrins prefer the extended conformation over bent conformation under the Ca2+-induced low-affinity condition.

2. When beta4 integrin is knocked down there is a loss of vimentin filaments from lamellipodia.

3. soluble nectin-4 ecto-domain promotes breast cancer induced angiogenesis via endothelial Integrin-beta4

4. our data indicate the existence of a positive feedback loop between KLF4 and ITGB4 that promotes GSC self-renewal and gliomagenesis, suggesting that ITGB4 may be a valuable therapeutic target for glioma.

5. Study reports co-segregation of three rare, protein-changing variants in the ITGB4 gene with schizophrenia (SCZ) in 2 families; provides further evidence from case control cohorts that variants in these families may contribute to susceptibility to SCZ and/or bipolar disorder in the wider population; also demonstrates that when these variants are present on the same haplotype there is an increase in cell proliferation.

6. RUNX1 regulates ITGA6 through a consensus RUNX1 binding motif in its promoter

7. High ITGB4 expression is associated with drug resistance in colorectal cancer.

8. ITGB4 plays a tumorigenic and pro-metastatic role mediated by Slug

9. N-glycosylation controlled the EGFR complex formation with integrin alpha5beta1 or alpha6beta4

10. correlation analysis indicated that the expression of ARRDC3 was negatively correlated with ITGbeta4 in clinical prostate cancer (PCa) tissues and cell lines. Our data revealed that ARRDC3 can serve as a tumor suppressor to inhibit PCa progression and an independent marker to predict the risk of biochemical recurrence and metastasis after radical resection of PCa.

11. ITGB4(+) cancer stem cell (CSC)-enriched mesenchymal cells reside in an intermediate epithelial/mesenchymal phenotypic state.

12. These findings suggest that the integrin beta4-FAK/Src signaling axis may play a crucial role in clonorchiasis-associated cholangiocarcinoma metastasis during tumor progression.

13. IGF2 also requires integrin binding for signaling functions, and the IGF2 mutants that cannot bind to integrins act as antagonists of IGF1R.

14. MUC5AC interacts with integrin beta4 that mediates phosphorylation of FAK at Y397 leading to lung cancer cell migration.

15. Increased integrin alpha6beta4 expression is associated with venous invasion and decreased overall survival in non-small cell lung cancers.

16. a significant reduction in the protein distribution of collagen IV (P<0.0001), collagen VII (P<0.001), collagen XVII (P<0.01), integrin beta4 (P<0.001) and laminin-332 (P<0.0001) in intrinsically aged skin.

17. alpha6beta4 integrin is a positive regulator of collective cell migration of A549 cells through influence on signal pathways in leader cells.

18. For the in vivo experiment, miR-182-5p overexpression also promoted the growth and progression of prostate cancer tumors. In this regard, we suggest that miR-182-5p may be a key androgen receptor-regulated factor that contributes to the development and metastasis of Chinese prostate cancers and may be a potential target for the early diagnosis and therapeutic studies of prostate cancer.

19. data indicate that the beta4 integrin/FAK complex and subsequent FAK activation are essential regulators during the tumorigenicity of colon cancer

20. This work investigates alpha6beta4 integrin genetic variations (A380T and R1281W) and breast cancer risk in an Argentinian population. No subjects carrying the R1281W mutation in the ITGB4 gene were found and this absence could reflect its high deleterious impact on proteins, so it would be eliminated from the population by natural selection.

Cow (Bovine) Integrin beta 4 (ITGB4) Interaktionspartner

1. integrin alpha6beta4 was indeed involved in dairy cow mammary development.