Integrin beta 4 Antikörper (AA 1612-1821)

Produktnummer ABIN968433

Produktdetails anti-Integrin beta 4 Antikörper

Target: Integrin beta 4 (ITGB4)

Bindungsspezifität: AA 1612-1821

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Integrin beta 4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Please refer to us for technical protocols.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human Integrin beta4 aa. 1612-1821

Klon: 7-CD104

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968533, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-Integrin beta 4 Antikörper (ABIN968433)

Shaw, Rabinovitz, Wang, Toker, Mercurio: "Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion." in: Cell, Vol. 91, Issue 7, pp. 949-60, (1998) (PubMed).

Mainiero, Pepe, Wary, Spinardi, Mohammadi, Schlessinger, Giancotti: "Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes." in: The EMBO journal, Vol. 14, Issue 18, pp. 4470-81, (1995) (PubMed).

Details zu Integrin beta 4

Target: Integrin beta 4 (ITGB4)

Andere Bezeichnung: CD104 (ITGB4 Produkte)

Synonyme: AA407042 antikoerper, C230078O20 antikoerper, CD104 antikoerper, integrin subunit beta 4 antikoerper, integrin beta 4 antikoerper, ITGB4 antikoerper, Itgb4 antikoerper

Hintergrund: Cell adhesion to extracellular matrix components or to cell surface proteins, especially those expressed by leukocytes and endothelial cells, is mediated by integrins. Integrins contain noncovalently associated alpha and beta subunits. At least 17 alpha and 8 beta subunits have been identified and these proteins can heterodimerize to form 22 different receptors. The alpha6beta4 integrin is a receptor for various laminins and binds with the highest affinity to laminins 4 and 5. It exhibits elevated expression in the basal cell layer of stratified epithelia, in Schwann cells at the onset of myelination, and in CD4-CD8- pre-T lymphocytes entering the thymus. In addition, alpha6beta4 expression is increased in squamous carcinomas where it promotes invasion through a targeting of PI3 kinase activity. The majority of beta4 comprises a cytoplasmic domain with unique signaling properties. The C-terminal portion of this domain contains two pairs of type III fibronectin-like motifs (FNIII) and a tyrosine activation motif (TAM). Additional domains in the cytoplasmic tail bind Shc and activate the MAPK pathway. Thus, integrin beta4 is an integrin subunit that is important for cell survival, growth, and differentiation. This antibody is routinely tested by western blot analysis.
Synonyms: Integrin beta4

Molekulargewicht: 200 kDa

Pathways: Integrin Complex