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AS-8351

Inh 796-42-9 2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone

/ (AS-8351)

1 image

Produktnummer ABIN7233233

Kurzübersicht für AS-8351 (ABIN7233233)

Applikation

Inhibition (Inh)

Chemical Name

2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone

Verwendungszweck

KDM5B histone demethylase inhibitor

Produktmerkmale

AS-8351 has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts1. It is believed that AS-8351 exerts its effects by modulating the activity of the JmjC domain-containing histone demethylases (JmjC-KDM). Thus each of the 22 genes in the JmjC-KDM family was abrogated using small hairpin RNAs which showed that only knocking down KDM5B (or using another KDM5B inhibitor such as PBIT) could phenocopy AS-8351 in generating cardiomyocytes. This strongly suggests that KDM5B is the target of AS-8351.

Reinheit

>98 %

Formel

C17H13N3O2

Löslichkeit

Soluble in DMSO (up to 45 mg/ml), in DMF (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml with warming)
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Radicicol
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Anacardic Acid
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Resveratrol
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SAHA (Vorinostat)
Inh Cell-permeable 149647-78-9 Suberoylanilide-hydroxamic acid

Phenylbutyrate Na
Inh 1716-12-7 4-Phenylbutyric acid, sodium salt

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Powder

Vorsichtsmaßnahmen

GHS – Classification
Not a hazardous substance or mixture

Lagerung

-20 °C
Hintergrund

NSC-51355,Epigenetics,Protein demethylase,Stem cells,Heart disease,Posttranslational modification,Chromatin

Molekulargewicht

291.3

CAS-Nummer

796-42-9

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