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AS-8351

Inh 796-42-9 2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone
Produktnummer ABIN7233233
  • Applikation
    Inhibition (Inh)
    Verwendungszweck
    KDM5B histone demethylase inhibitor
    Produktmerkmale
    AS-8351 has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts1. It is believed that AS-8351 exerts its effects by modulating the activity of the JmjC domain-containing histone demethylases (JmjC-KDM). Thus each of the 22 genes in the JmjC-KDM family was abrogated using small hairpin RNAs which showed that only knocking down KDM5B (or using another KDM5B inhibitor such as PBIT) could phenocopy AS-8351 in generating cardiomyocytes. This strongly suggests that KDM5B is the target of AS-8351.
    Reinheit
    >98 %
    Chemical Name
    2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone
    Formel
    C17H13N3O2
    Löslichkeit
    Soluble in DMSO (up to 45 mg/ml), in DMF (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml with warming)
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Powder
    Vorsichtsmaßnahmen
    GHS – Classification
    Not a hazardous substance or mixture
    Lagerung
    -20 °C
  • Hintergrund
    NSC-51355,Epigenetics,Protein demethylase,Stem cells,Heart disease,Posttranslational modification,Chromatin
    Molekulargewicht
    291.3
    CAS-Nummer
    796-42-9
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