AS-8351
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- Applikation
- Inhibition (Inh)
- Verwendungszweck
- KDM5B histone demethylase inhibitor
- Produktmerkmale
- AS-8351 has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts1. It is believed that AS-8351 exerts its effects by modulating the activity of the JmjC domain-containing histone demethylases (JmjC-KDM). Thus each of the 22 genes in the JmjC-KDM family was abrogated using small hairpin RNAs which showed that only knocking down KDM5B (or using another KDM5B inhibitor such as PBIT) could phenocopy AS-8351 in generating cardiomyocytes. This strongly suggests that KDM5B is the target of AS-8351.
- Reinheit
- >98 %
- Chemical Name
- 2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone
- Formel
- C17H13N3O2
- Löslichkeit
- Soluble in DMSO (up to 45 mg/ml), in DMF (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml with warming)
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Powder
- Vorsichtsmaßnahmen
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GHS – Classification
Not a hazardous substance or mixture - Lagerung
- -20 °C
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- Hintergrund
- NSC-51355,Epigenetics,Protein demethylase,Stem cells,Heart disease,Posttranslational modification,Chromatin
- Molekulargewicht
- 291.3
- CAS-Nummer
- 796-42-9
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