UNC-0379
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- Applikation
- Inhibition (Inh)
- Verwendungszweck
- SETD8 inhibitor
- Produktmerkmale
- UNC0379 is an inhibitor of the lysine methyltransferase SETD8 with selectivity over 15 other methyltransferases. IC50's = 7.3 μM in a radioactive methyl transfer assay and 9.0 μM in an MCE assay. UNC0379 treatment of SY5Y and NGP neuroblastoma cell lines lead to activation of p53 and decreased tumor growth in an ex-vivo tumorigenicity assay.
- Reinheit
- >98 %
- Chemical Name
- 6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)-pentyl)quinazolin-4-amine
- Formel
- C23H35N5O2
- Löslichkeit
- Soluble in DMSO (up to 30 mg/ml).
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Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
RadicicolInh 12772-57-5
Geldanamycin- FITCInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
NicotinamideInh 98-92-0 Pyridine-3-carboxylic acid amide
5-AzacytidineInh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
ResveratrolAct 501-36-0 3,4',5-Trihydroxy-trans-stilbene
PanobinostatInh 404950-80-7 (E)-N-Hydroxy-3-(4-((2-(2-methyl-1H-indol-3-yl)ethylamino)methyl)phenyl)acrylamide
HPA (Hexyl-4-pentynoic acid)Inh Cell-permeable 96017-59-3 2-(2-Propynyl)octanoic acid (racemic)
EX-527Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)
DaminozideInh 1596-84-5 1-(2,2-Dimethylhydrazide)butanedioic acid
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Powder
- Lagerung
- -20 °C
-
- Hintergrund
- Proliferation,Epigenetics,p53,Protein methyltransferase,Neuroscience,Cancer,Posttranslational modification,Chromatin
- Molekulargewicht
- 413.56
- CAS-Nummer
- 1620401-82-2
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