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5-Azacytidine

Name: 5-Azacytidine
Brand: antibodies-online
SKU: ABIN7233228
Price: 75.38 EUR
Availability: InStock

Inh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

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Produktnummer ABIN7233228

Datenblatt (PDF)

Kurzübersicht für 5-Azacytidine (ABIN7233228)

Applikation

Inhibition (Inh)

Chemical Name

4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

Permeabilität

Cell-permeable

Verwendungszweck

DNA hypomethylation agent

Produktmerkmale

Specific inhibitor of DNA methyltransferase. Incorporates into DNA and covalently reacts with and inhibits DNA methyltransferases. Induces demethylation and reactivation of silenced genes. Increases stem cell reprogramming efficiency. Induces cardiac differentiation of human mesenchymal stem cells by activating ERK. Induces apoptosis in multiple myeloma cells via ATR-mediated DNA double strand breaks. Cell permeable.

Reinheit

>98 %

Formel

C8H12N4O5

Löslichkeit

Soluble in DMSO (up to 25 mg/ml), or in Water (up to 12 mg/ml).
Geldanamycin
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Radicicol
Inh 12772-57-5

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Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

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Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Powder

Vorsichtsmaßnahmen

GHS – Classification
Acute toxicity, Oral (Category 4), H302
Germ cell mutagenicity (Category 2), H341
Carcinogenicity (Category 1A), H350
Reproductive toxicity (Category 1B), H360
Specific target organ toxicity - repeated exposure (Category 1), H372
Long-term (chronic) aquatic hazard (Category 1), H410

Lagerung

-20 °C
Hintergrund

Ladakamycin, U-18496, NSC-102816, AzaC,Epigenetics,Chromatin,DNA methyltransferase,Stem cells,Cell death,Infectious disease,Apoptosis inducer,DNA damage

Molekulargewicht

244.2

CAS-Nummer

320-67-2