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Geldanamycin- FITC

Name: Geldanamycin- FITC
Brand: antibodies-online
SKU: ABIN1027734
Price: 485.36 EUR
Availability: InStock

Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

1 image

(1 reference)

Produktnummer ABIN1027734

Kurzübersicht für Geldanamycin- FITC (ABIN1027734)

Applikation

Inhibition (Inh)

Chemical Name

(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Verwendungszweck

Hsp90 fluorescent probe

Spezifität

Geldanamycin is a benzoquinoid ansamycin produced by Streptomyces hygroscopicus. It binds specifically to heat shock protein HSP90 and downregulates target proteins including tyrosine kinases, steroid receptors, transcription factors and cell cycle regulatory kinases. It induces the inactivation, destabilization and eventual degradation of HIF-1alpha. This is specifically a novel geldanamycin fluorescent probe that may be used in a fluorescence polarization assay for Hsp90 inhibitors. May also be used for detection of cell surface Hsp90. Other geldanamycin fluorophores (BODPY) have been reported and used in FP HTS assays.

Produktmerkmale

Hsp90 inhibitor.

Reinheit

>98 % (TLC), NMR (Conforms)

Formel

C55H63N5O13S

Löslichkeit

May be dissolved in DMSO (>10 mg/ml)
Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Radicicol
Inh 12772-57-5

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Inh 16611-84-0 2-Hydroxy-6-pentadecylbenzoic acid

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Act 501-36-0 3,4',5-Trihydroxy-trans-stilbene

SAHA (Vorinostat)
Inh Cell-permeable 149647-78-9 Suberoylanilide-hydroxamic acid

Phenylbutyrate Na
Inh 1716-12-7 4-Phenylbutyric acid, sodium salt

AS-8351
Inh 796-42-9 2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone

Kommentare

Source: Synthetic.
Appearance: Purple Solid

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Solid

Vorsichtsmaßnahmen

Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R68- Possible risk of irreversible effects

Handhabung

Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R68- Possible risk of irreversible effects

Lagerung

-20 °C
Austin, Pettit, Magnolo, Sanvoisin, Chen, Wood, Freeman, Pengelly, Hughes: "Fragment screening using capillary electrophoresis (CEfrag) for hit identification of heat shock protein 90 ATPase inhibitors." in: Journal of biomolecular screening, Vol. 17, Issue 7, pp. 868-76, (2012) (PubMed).
Molekulargewicht

1034.2

CAS-Nummer

30562-34-6