IKZF1 Produkte
(IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))
Kategorien
This gene encodes a transcription factor that belongs to the family of zinc-finger DNA binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. All isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homodimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and contain the nuclear localization signal, resulting in members with and without DNA-binding properties. Only few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and thought to function as dominant negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2011].
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Ausgewählte IKZF1 Kategorien
IKZF1 Antikörper
High quality antibodies with extensive validation data.
IKZF1 ELISA Kits
Reliable ELISA kits for a wide range of species.
IKZF1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene IKZF1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, FACS, IHC (p)
Validierungen
- (1)
- (4)
Kat. Nr.
ABIN654180
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC, IF
Validierungen
- (4)
Kat. Nr.
ABIN7150361
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IF, ChIP
Validierungen
- (4)
Kat. Nr.
ABIN3015622
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene IKZF1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6967566
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Validierungen
Kat. Nr.
ABIN1130242
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Chicken
Analytical Method
Validierungen
Kat. Nr.
ABIN1130240
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene IKZF1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1307650
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7123400
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
- (1)
Kat. Nr.
ABIN3093023
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren IKZF1 Produkten
: "Activation of c-Abl Kinase Potentiates the Anti-myeloma Drug Lenalidomide by Promoting DDA1 Protein Recruitment to the CRL4 Ubiquitin Ligase." in: The Journal of biological chemistry, Vol. 292, Issue 9, pp. 3683-3691, (2017) (PubMed).: "Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia." in: The Journal of biological chemistry, Vol. 291, Issue 8, pp. 4004-18, (2016) (PubMed).
: "Epstein-Barr virus utilizes Ikaros in regulating its latent-lytic switch in B cells." in: Journal of virology, Vol. 88, Issue 9, pp. 4811-27, (2014) (PubMed).
: "Transcriptional regulation of the Ikzf1 locus." in: Blood, Vol. 122, Issue 18, pp. 3149-59, (2013) (PubMed).
: "Ikaros represses and activates PU.1 cell-type-specifically through the multifunctional Sfpi1 URE and a myeloid specific enhancer." in: Oncogene, Vol. 31, Issue 43, pp. 4647-54, (2012) (PubMed).
: "Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos." in: Nucleic acids research, Vol. 40, Issue 15, pp. 7303-18, (2012) (PubMed).
: "Ikaros modulates cholesterol uptake: a link between tumor suppression and differentiation." in: Cancer research, Vol. 68, Issue 10, pp. 3715-23, (2008) (PubMed).
: "Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia." in: Nature, Vol. 446, Issue 7137, pp. 758-64, (2007) (PubMed).
: "Haematopoietic cell-fate decisions, chromatin regulation and ikaros." in: Nature reviews. Immunology, Vol. 2, Issue 3, pp. 162-74, (2002) (PubMed).
: "Ikaros: a key regulator of haematopoiesis." in: The international journal of biochemistry & cell biology, Vol. 34, Issue 10, pp. 1304-7, (2002) (PubMed).
Synonyme und alternative Namen zu IKZF1
IKAROS family zinc finger 1 (IKZF1), IKAROS family zinc finger 1 (Ikzf1), IKAROS family zinc finger 1 (Ikaros) (ikzf1), IKAROS family zinc finger 1 (ikzf1), 5832432G11Rik, hIk-1, hik-1, hlk-1, Hs.54452, hs.54452, IK1, ik1, IKAROS, ikaros, Ikaros, ikzf1, LyF-1, LYF1, lyf1, MGC108252, mKIAA4227, PRO0758, pro0758, RGD1562979, Zfpn1a1, ZNFN1A1, znfn1a1, Znfn1a1Bezeichner auf Proteinebene für IKZF1
- CLL-associated antigen KW-6
- DNA-binding protein Ikaros
- Ikaros (zinc finger protein)
- ikaros family zinc finger protein 1
- lymphoid transcription factor LyF-1
- zinc finger protein, subfamily 1A, 1 (Ikaros)
- Ikaros transcription factor
- KAROS family zinc finger 1 (Ikaros)
- IKAROS family zinc finger 1 (Ikaros)
- DNA-binding protein Ikaros-like
- zinc finger protein subfamily 1A, 1
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