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Significantly higher CRF1 and CRF2 receptor (zeige CRHR2 Proteine) levels after CNS sensitization were detected in the Hippocampus.
found no differences in genotype distributions between heroin-dependent subjects and controls. However, identified a prominent interaction of one variant of the CRHBP (zeige CRHBP Proteine) gene predicting the risk of heroin relapse in the chronically stressed subjects.
The large scale refinement of transmembrane helices of the CRFR1 homology model resulted in the significant improvement of its accuracy with respect to the crystal structure of CRFR1, especially in the binding site area.
Data suggest that corticotrophin-releasing hormone (CRH (zeige CRH Proteine)) is able to stimulate copeptin (zeige AVP Proteine) release in healthy controls suggesting direct interaction of CRH/CRH (zeige CRH Proteine)-receptor signaling and vasopressin (zeige AVP Proteine); these interactions appear to be altered in patients with pituitary disease; copeptin (zeige AVP Proteine) may be serum biomarker of altered CRH/CRH (zeige CRH Proteine)-receptor signaling in pituitary diseases.
The negative and positive inputs are integrated by hypoxic initiation and duration in CRHR1 transcription.
This study suggests that SNPs in the CRHR1 gene may influence BDNF (zeige BDNF Proteine) levels in crack cocaine addiction.
found an interaction between CRHR1 Single Nucleotide Polymorphisms and maternal depression, with the homozygous minor genotype acting as a protective factor against brooding in the presence of maternal depression.
The results reveal that specific CRHR1 polymorphisms moderate the effect of Early life stress on emotional empathy.
A significant increase in CRH (zeige CRH Proteine) and CRHR-1 expression was significantly correlated with psychological stress in vitiligo (zeige MITF Proteine).
The present study identified a potential role of CRHR1 hypomethylation - conferring increased CRHR1 expression - in panic disorder and a related dimensional intermediate phenotype.
Expression of Crhr1 is decreased in the pituitary gland of corticotropin-releasing hormone (zeige CRH Proteine) knock-out mice exposed to repeat stress.
CRF-R1 expression levels were proportional to the severity of DSS (zeige PMP22 Proteine)-induced colitis. Activation of CRF-R1 aggravated inflammation, and inhibition of CRF-R1 ameliorates inflammation evaluated by the DAI (zeige ZBP1 Proteine) and histological scores in the colon samples of the DSS (zeige PMP22 Proteine)-treated mice.
report a sexually dimorphic expression of CRFR1 within the rostral portion of the anteroventral periventricular nucleus of the hypothalamus
These results revealed a prominent role for CRF1 signaling in mast cells as a positive modulator of stimuli-induced degranulation.
switch in G protein coupling for type 1 corticotropin-releasing factor (zeige CRH Proteine) receptors promotes excitability in epileptic brains
Study characterized the influences of early-life stress on the developmental trajectory of hippocampal pyramidal neurons, and highlighted the critical role of CRHR1 in modulating these negative outcomes evoked by early-life stress.
the beneficial effects of CRFR1 antagonism seen in transgenic mice may be mechanistically linked to the modulation of oxidative stress pathways
CRF plays a marked anxiogenic role at CRF1 receptors in the amygdala of mice exposed to the elevated plus maze.
found that corticotropin-releasing factor type 1 receptor within the paraventricular nucleus of the hypothalamus is an important central component of hypothalamic-pituitary-adrenal axis regulation that prepares the organism for successive exposure to stressful stimuli.
Excitability of genetically isolated CRF (zeige CRH Proteine)-receptive (CRFR1) neurons in the central nucleus of the amygdala (CeA (zeige CEA Proteine)) is potently enhanced by CRF (zeige CRH Proteine) and that CRFR1 signaling in the CeA (zeige CEA Proteine) is critical for discriminative fear
These results suggest that a regulatory system exists in the bovine thyroid gland based on UCN, CRHR1 and CRHR2 and that UCN plays a role in the regulation of thyroid physiological functions through an autocrine/paracrine mechanism.
CRHR1 and CRHR2 (zeige CRHR2 Proteine) are expressed in the bovine adrenal gland.
results indicate that arginine vasopressin (zeige AVP Proteine) receptor V3 and corticotropin-releasing factor receptor 1 mRNAs are coordinately downregulated in the anterior pituitary during systemic inflammatory stress in cattle[AVP receptor V3 (zeige AVPR1B Proteine)]
CRF (zeige CRH Proteine) is expressed in tadpole tail, is up-regulated by environmental stressors, and is cytoprotective
CRFr1 activation mediates intestinal mucosa barrier dysfunction and hypersecretion in early-weaned piglets, whereas CRFr2 (zeige CRHR2 Proteine) activation may be responsible for novel protective properties in the porcine intestine in response to early life stress.
The expression of UCN, CRHR1, CRHR2 and CRHBP by immunohistochemistry, Western blot and reverse transcription with the polymerase chain reaction (RT-PCR) in the horse thyroid gland, was investigated
The results of this study suggested that variation in CRHR1 may influence brain function before any childhood adversity and may be a diathesis for the interaction between CRHR1 genotypes and childhood trauma reported to affect human psychopathology
Results suggest that blockade of CRF1 and CRF2 receptors in the basolateral and central nuclei of the amygdala reduces the duration of tonic immobility behavior associated with extreme threat situations, probably due to decreased fear and/or anxiety.
This locus represents naturally occurring readthrough transcription between neighboring genes CRHR1-IT1, CRHR1 intronic transcript 1 (Gene ID: 147081) and CRHR1, corticotropin releasing hormone receptor 1 (Gene ID: 1394) on chromosome 17. The readthrough transcript encodes a protein that shares sequence identity with the product of the CRHR1 gene.
corticotropin releasing hormone receptor variant 1e
, corticotropin releasing hormone receptor variant 1g
, corticotropin-releasing factor receptor 1
, corticotropin-releasing factor type 1 receptor
, corticotropin-releasing hormone receptor 1
, seven transmembrane helix receptor
, corticotropin releasing factor receptor type 1
, CRH-R 1
, corticotrophin releasing hormone receptor 1
, corticotropin releasing hormone 1
, CRF 1 receptor
, corticotropin releasing hormone receptor type I
, corticotropin releasing hormone receptor 1
, corticotrophin-releasing factor type 1 alpha receptor
, CRHR1-IT1-CRHR1 protein
, CRHR1-IT1-CRHR1 readthrough
, Corticotropin-releasing hormone receptor 1