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CRHR1-by-familial environment interactions influence both outwardly-directed aggression as well as mood and anxiety disorder symptoms in a sex-specific manner.
CRHR1 might contribute to a predisposition to Internalizing Disorders, considering its key role in the stress response/modulation promoted by the hypothalamic-pituitary-adrenal axis.
Results show that CRHR1 is expressed in human articular chondrocytes (AC) and binds to UCN1 to promote survival of AC cells in the absence of pro-apoptotic stimuli.
Patients were different from those previously studied. We measured the expression of the pituitary-specific hormone genes and type 1 corticotrophin-releasing hormone and arginine vasopressin 1b receptors, by quantitative real-time polymerase chain reaction using TaqMan probes.
The CRHR1 TAT haplotype is associated with cognitive features of depression including difficulty with decision-making, higher rumination, and poorer learning and memory. It will be important in future research to identify the specific molecular mechanisms for CRF1 signaling that contribute to depression-related cognitive dysfunction. [review]
Significantly higher CRF1 and CRF2 receptor levels after CNS sensitization were detected in the Hippocampus.
found no differences in genotype distributions between heroin-dependent subjects and controls. However, identified a prominent interaction of one variant of the CRHBP gene predicting the risk of heroin relapse in the chronically stressed subjects.
The large scale refinement of transmembrane helices of the CRFR1 homology model resulted in the significant improvement of its accuracy with respect to the crystal structure of CRFR1, especially in the binding site area.
Data suggest that corticotrophin-releasing hormone (CRH) is able to stimulate copeptin release in healthy controls suggesting direct interaction of CRH/CRH-receptor signaling and vasopressin; these interactions appear to be altered in patients with pituitary disease; copeptin may be serum biomarker of altered CRH/CRH-receptor signaling in pituitary diseases.
This study reports the crystal structure of the transmembrane domain of human CRF1R in complex with the small-molecule antagonist CP-376395 in a hexagonal setting with translational non-crystallographic symmetry.
The negative and positive inputs are integrated by hypoxic initiation and duration in CRHR1 transcription.
This study suggests that SNPs in the CRHR1 gene may influence BDNF levels in crack cocaine addiction.
found an interaction between CRHR1 Single Nucleotide Polymorphisms and maternal depression, with the homozygous minor genotype acting as a protective factor against brooding in the presence of maternal depression.
The results reveal that specific CRHR1 polymorphisms moderate the effect of Early life stress on emotional empathy.
A significant increase in CRH and CRHR-1 expression was significantly correlated with psychological stress in vitiligo.
The present study identified a potential role of CRHR1 hypomethylation - conferring increased CRHR1 expression - in panic disorder and a related dimensional intermediate phenotype.
CRH-R1 contributes to the dysregulated stress responsiveness in IBS.
These results revealed a prominent role for CRF1 signaling in mast cells as a positive modulator of stimuli-induced degranulation.
This review showed a significant genetic association in most studies in CRHR1 genes with a high rate of attempted suicide.
Our results strengthen the evidence for the role of CRHR1 single nucleotide polymorphisms in major depressive disorder susceptibility and suggest that their effects may be modulated by sex and smoking status.
In this study, mild blast-induced traumatic brain injury (mbTBI) did not alter CRFR1 gene expression in males or females. However, mbTBI disrupted CRFR2 gene expression in different limbic structures in males and females.
the miR-34-dependent modulation of CRFR1 expression may be involved in the dorsal raphe nuclei regulation of stress-coping strategies.
Expression of Crhr1 is decreased in the pituitary gland of corticotropin-releasing hormone knock-out mice exposed to repeat stress.
CRF-R1 expression levels were proportional to the severity of DSS-induced colitis. Activation of CRF-R1 aggravated inflammation, and inhibition of CRF-R1 ameliorates inflammation evaluated by the DAI and histological scores in the colon samples of the DSS-treated mice.
report a sexually dimorphic expression of CRFR1 within the rostral portion of the anteroventral periventricular nucleus of the hypothalamus
switch in G protein coupling for type 1 corticotropin-releasing factor receptors promotes excitability in epileptic brains
Study characterized the influences of early-life stress on the developmental trajectory of hippocampal pyramidal neurons, and highlighted the critical role of CRHR1 in modulating these negative outcomes evoked by early-life stress.
the beneficial effects of CRFR1 antagonism seen in transgenic mice may be mechanistically linked to the modulation of oxidative stress pathways
CRF plays a marked anxiogenic role at CRF1 receptors in the amygdala of mice exposed to the elevated plus maze.
found that corticotropin-releasing factor type 1 receptor within the paraventricular nucleus of the hypothalamus is an important central component of hypothalamic-pituitary-adrenal axis regulation that prepares the organism for successive exposure to stressful stimuli.
Excitability of genetically isolated CRF-receptive (CRFR1) neurons in the central nucleus of the amygdala (CeA) is potently enhanced by CRF and that CRFR1 signaling in the CeA is critical for discriminative fear
Study demonstrated that CRF1 receptor-deficiency prolongs whereas CRF2 receptor-deficiency shortens the duration of recognition memory deficits induced by morphine discontinuation, unraveling opposite roles for the two known CRF receptor subtypes in cognitive dysfunction associated with opiate withdrawal.
CRFR1, in a subset of AgRP neurons, plays a regulatory role that enables appropriate sympathetic nervous system activation and consequently protects the organism from hypothermia and hypoglycemia.
the cyclic AMP (cAMP) response of CRHR1 in physiologically relevant scenarios engages separate cAMP sources, involving the atypical soluble adenylyl cyclase (sAC) in addition to transmembrane adenylyl cyclases (tmACs).
Data suggest a physiologically relevant role for local corticotropin-releasing hormone signaling towards shaping the neuronal circuitry within the mouse olfactory bulb.
A role was found for extra-hypothalamic CRF-R1 in stress-escalated alcohol drinking.
This study demonstrated that an anatomical mechanism for sex-differences in the convergent modulation of ventrolateral medulla catecholaminergic neurons by CRF and glutamate.
these results indicate that NPS-NPSR system may regulate locomotion together with the CRF1 system in SN.
bladder smooth muscle contractility is unchanged by CsA; however, there are changes in the levels of the downstream transcription factors MEF-2 and NFAT.
These results suggest that a regulatory system exists in the bovine thyroid gland based on UCN, CRHR1 and CRHR2 and that UCN plays a role in the regulation of thyroid physiological functions through an autocrine/paracrine mechanism.
CRHR1 and CRHR2 are expressed in the bovine adrenal gland.
results indicate that arginine vasopressin receptor V3 and corticotropin-releasing factor receptor 1 mRNAs are coordinately downregulated in the anterior pituitary during systemic inflammatory stress in cattle[AVP receptor V3]
CRF is expressed in tadpole tail, is up-regulated by environmental stressors, and is cytoprotective
CRFr1 activation mediates intestinal mucosa barrier dysfunction and hypersecretion in early-weaned piglets, whereas CRFr2 activation may be responsible for novel protective properties in the porcine intestine in response to early life stress.
The expression of UCN, CRHR1, CRHR2 and CRHBP by immunohistochemistry, Western blot and reverse transcription with the polymerase chain reaction (RT-PCR) in the horse thyroid gland, was investigated
The results of this study suggested that variation in CRHR1 may influence brain function before any childhood adversity and may be a diathesis for the interaction between CRHR1 genotypes and childhood trauma reported to affect human psychopathology
Results suggest that blockade of CRF1 and CRF2 receptors in the basolateral and central nuclei of the amygdala reduces the duration of tonic immobility behavior associated with extreme threat situations, probably due to decreased fear and/or anxiety.
This locus represents naturally occurring readthrough transcription between neighboring genes CRHR1-IT1, CRHR1 intronic transcript 1 (Gene ID: 147081) and CRHR1, corticotropin releasing hormone receptor 1 (Gene ID: 1394) on chromosome 17. The readthrough transcript encodes a protein that shares sequence identity with the product of the CRHR1 gene.
corticotropin releasing hormone receptor variant 1e
, corticotropin releasing hormone receptor variant 1g
, corticotropin-releasing factor receptor 1
, corticotropin-releasing factor type 1 receptor
, corticotropin-releasing hormone receptor 1
, seven transmembrane helix receptor
, corticotropin releasing factor receptor type 1
, CRH-R 1
, corticotrophin releasing hormone receptor 1
, corticotropin releasing hormone 1
, CRF 1 receptor
, corticotropin releasing hormone receptor type I
, corticotropin releasing hormone receptor 1
, corticotrophin-releasing factor type 1 alpha receptor
, CRHR1-IT1-CRHR1 protein
, CRHR1-IT1-CRHR1 readthrough
, Corticotropin-releasing hormone receptor 1