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anti-Virus OAS1B Antikörper:
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West Nile Virus (WNV) Polyclonal OAS1B Primary Antibody für IF, ELISA - ABIN2477148
Orikasa, Koyanagi, Motomura, Kudo, Togashi: Experience with non-sterile intermittent self-catheterization. in The Journal of urology 1976
Show all 4 Pubmed References
Oas1b status as wild-type or truncated, and overall Oas1b gene dosage, link with novel innate immune gene signatures that impact specific biological pathways for the control of flavivirus infection and immunity through both Oas1b-dependent and independent processes.
These data indicate that the different susceptibility to the antiviral activity of Oas1b resulted in a difference in neurovirulence in the two tick-borne encephalitis virus strains.
Oas1b is part of a complex located in the ER and that ABCF3 is a component of the Flv(r)-mediated resistance mechanism.
Activation of Oas1b gene expression by type I IFN requires only STAT2, not STAT1.
Oas1b inhibits flavivirus replication by an alternative mechanism that overrides the proviral effect of reducing 2-5A accumulation and RNase L activation.
A positional cloning strategy was used to identify 22 genes from the Flv gene interval including 10 members of the 2'-5'-oligoadenylate synthetase gene family.
A nonsense mutation in the gene is associated with West Nile virus susceptibility in laboratory mice
Oas1b represents an antiviral pathway that exerts its inhibitory effect on West Nile virus replication by preventing viral RNA accumulation inside infected cells
Knock-in of the Oas1b resistance allele into a susceptible mouse strain produced mice with the flavivirus resistance phenotype, confirming that this phenotype is mediated by a single gene.
Oas1b mice show resistance to the infection of West Nile virus but not of influenza virus.
This gene is a member of the 2'-5' oligoA synthetase family, which are clustered on chromosome 5. The encoded protein functions in the interferon-regulated OAS/RNase L system, which mediates RNA decay as part of the innate antiviral immunity pathway. The protein binds double-stranded RNA and oligomerizes ATP, which activate the single-stranded RNA cleavage enzyme RNase L. This protein mediates resistance to flaviviruses such as West Nile virus. The majority of wild mouse strains produce a functional protein and are resistant to flavivirus infection, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a premature stop codon that inactivates this gene product.
(2-5')oligo(A) synthase 1B
, (2-5')oligo(A) synthetase 1b
, 2',5'-oligoadenylate synthetase-like 1
, 2'-5'-oligoadenylate synthase 1B
, 2'-5'-oligoadenylate synthase-like protein 1
, 2'-5'-oligoadenylate synthetase-like protein 1
, 2-5A synthase 1B
, 2-5A synthetase 1B
, Flavivirus resistance
, inactive 2'-5'-oligoadenylate synthase 1B
, 2'5' oligoadenylate synthetase-2
, 25 oligoadenylate synthetase-2