anti-Casein Kinase 1 delta (CSNK1D) Antikörper

Human Casein Kinase 1, delta (CSNK1D) Interaktionspartner

1. Our results reveal a new mechanism of ZNF322A oncoprotein destruction regulated by the CK1delta/GSK3beta/FBXW7a axis. Deregulation of this signaling axis results in ZNF322A overexpression and promotes cancer progression

2. Report temperature-compensated CKIdelta-dependent multi-site phosphorylation in mammals underlies temperature compensated phosphorylation in circadian clocks.

3. Study describes a specific mechanism for the regulation of CK1delta activity by proline-directed kinases, and demonstrate the relevance of this regulation in the control of a key CK1delta substrate, the PER2 protein.

4. Protein kinase C alpha (PKCalpha) is able to phosphorylate CK1delta at its C-terminally located residues S328, T329, and S370.

5. the results suggest that CK1delta activity can be modulated by the interplay between CK1delta and CDK2/E or CDK5/p35.

6. CK1delta inhibition represents a promising strategy for targeted treatment in human breast cancer with Wnt/beta-catenin involvement.

7. Expression of truncated hyperactive form of CKIdelta causes mislocalization and aggregation of TDP-43 in cultured cells.

8. Inhibition of CK1delta increases lipid droplet formation and proliferation of both cancer and normal cells specifically under hypoxia and in an HIF-1alpha- and lipin-1-dependent manner.

9. site-specific phosphorylation of adiponectin, especially at sites targeted by CK1delta in vitro, provides an additional regulatory mechanism for modulating adiponectin complex formation and function.

10. The dynamical and conformational properties for each of three isoforms of CK1 are explored through molecular dynamics (MD) simulations.

11. Results indicate that changes in the expression levels of casein kinase 1 isoforms CK1delta and DK1epsilon in colorectal tumors correlate with patients' survival.

12. CK1delta and CK1epsilon play a decisive role in triggering late steps of pre-40S maturation that are required for acquisition of functionality of 40S ribosomal subunits in protein translation.

13. role for CK1delta in controlling the cell cycle

14. molecular docking studies to examine the effect of the S97 mutation on its ATP-binding affinity; results explained the underlying molecular mechanism behind the observed cancer associated phenotype caused by S97C mutation in CK1delta protein

15. decreases in CKIdelta activity can contribute to the pathogenesis of migraine.

16. These results do not support that genetic variation in CSNK1D and CSNK1E is a susceptibility factor for major psychiatric disorders in the Japanese population.

17. Casein kinase 1 proteomics reveal prohibitin 2 function in molecular clock

18. casein kinase 1-delta phosphorylation of PGC-1alpha within its arginine/serine-rich domain enhances its degradation through the proteasome system

19. CKIdelta-EB1 complexes contribute to the increase in microtubule growth speeds observed in polarized T cells, a mechanism that might serve to generate long-stable microtubules necessary for centrosome translocation.

20. These results provide strong evidence that the centrosomal localization of CK1delta is required for Wnt-3a-dependent neuritogenesis.

Mouse (Murine) Casein Kinase 1, delta (CSNK1D) Interaktionspartner

1. CK1delta/epsilon disruption mouse had a long (27.4 h) behavioral period to which peripheral clocks entrained in vivo, albeit with an advanced phase ( approximately 6 h).

2. Studied roles of CK1delta and CK1e in regulation of PER2 in circadian rhythm.

3. the impact of obesity on the circadian system in mice at a behavioural and molecular level was assessed, and determined whether pharmacological targeting of casein kinase 1delta and epsilon (CK1delta/epsilon), key regulators of the circadian clock, can confer metabolic benefit.

4. Here, the authors identify another Wnt signaling amplifier, CKIepsilon, which is specifically upregulated in intestinal stem cells and is essential for intestinal stem cell maintenance, especially in the absence of its close isoform CKIdelta.

5. Report temperature-compensated CKIdelta-dependent multi-site phosphorylation in mammals underlies temperature compensated phosphorylation in circadian clocks.

6. Together, these findings suggest that CK1delta contributes to the efficient repair of DNA damage and the proper functioning of mitotic checkpoints by maintaining appropriate levels of Chk1.

7. we conclude that APC/C(Cdh1) controls CK1 delta levels to balance proliferation and cell-cycle exit in the developing CNS

8. CK1delta mediates primary ciliogenesis by multiple mechanisms, one involving its centrosomal function and another dependent on its interaction with AKAP450 at the Golgi.

9. this article reports the crystallization and structure determination of a new crystal form of casein kinase I delta belonging to space group P21.

10. decreases in CKIdelta activity can contribute to the pathogenesis of migraine.

11. REGgamma-deficient mice develop premature aging phenotypes that are associated with abnormal accumulation of casein kinase (CK)1delta and p53. Antibody array analysis identified CK1delta as a direct target of REGgamma.

12. inactivating mutations in CK1delta impair SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivo

13. CK1delta plays a more prominent role than CK1epsilon in the maintenance of 24-hour rhythms in the master circadian oscillator

14. These results provide strong evidence that the centrosomal localization of CK1delta is required for Wnt-3a-dependent neuritogenesis.

15. The results suggest that CK1delta/epsilon binds to and phosphorylates the N-terminal domain of Dnmt1 and regulates Dnmt1 function by reducing the DNA-binding activity.

16. physical interaction between PER and CKIdelta/epsilon required for circadian rhythm

17. Results indicate that CKIdelta plays several roles in lymphocyte physiology.

18. CK1 regulates fast synaptic transmission by glutamate in brain. Activation of CK1 decreases NMDA receptor activity in the striatum via activation by this kinase of protein phosphatase 1 &/or 2A & increased dephosphorylation of NMDA receptors.

19. snapin is a new substrate of CK1delta

20. The balance between beta-arr and CK1/2 determines whether WNT/RAC-1 or other non-canonical WNT pathways are activated.

Zebrafish Casein Kinase 1, delta (CSNK1D) Interaktionspartner

1. Data indicate that CK1delta inhibition abolishes rhythmic pineal aanat2 mRNA expression.

2. The phosphorylation of p53 by CK1 is an isoform-specific reaction to the K(221)RQK(224) loop.

Xenopus laevis Casein Kinase 1, delta (CSNK1D) Interaktionspartner

1. The results demonstrate a high degree of evolutionary conservation of fly and vertebrate CKIdelta and of the functions affected by their period-shortening mutations.