Granulin Proteine
(Granulin (GRN))
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008].
| Catalog no. | Produkt | Reaktivität | Wirt / Klonalität | Anwendung | Preis & Lieferzeit |
|---|---|---|---|---|---|
| Granulin Protein (GRN) (AA 1-247) (His tag) | Agrotis Segetum Granulosis Virus (AsGV) | Hefe |
|
2.632,67 €
Preis anzeigen
|
|
| Granulin Protein (GRN) (AA 1-248) (His tag) | Trichoplusia ni Granulosis Virus (TnGV) | Hefe |
|
2.634,50 €
Preis anzeigen
|
|
| Granulin Protein (GRN) (AA 1-247) (His tag) | Pieris brassicae Granulosis Virus (PbGV) | Hefe |
|
2.632,67 €
Preis anzeigen
|
|
| Granulin Protein (GRN) (AA 1-248) (His tag) | Cydia pomonella Granulosis Virus (CpGV) | Hefe |
|
2.634,50 €
Preis anzeigen
|
|
| Granulin Protein (GRN) (AA 18-588) (His tag) | Ratte | Hefe |
|
1.624,33 €
Preis anzeigen
|
|
| Granulin Protein (GRN) (AA 1-248) (His tag) | Xestia c-nigrum Granulosis Virus (XnGV) | Hefe |
|
2.634,50 €
Preis anzeigen
|
|
| Granulin Protein (GRN) (AA 1-248) (His tag) | Choristoneura fumiferana Granulovirus (CfGV) | Hefe |
|
2.634,50 €
Preis anzeigen
|
|
| Granulin Protein (GRN) | Human | – |
|
1.950,93 €
Preis anzeigen
|
|
| Granulin Protein (GRN) (His tag) | Human | Escherichia coli (E. coli) |
|
503,00 €
Preis anzeigen
|
Protein
- ELISA (ELISA: Angegebene Anwendung)
- Spezies
- Agrotis Segetum Granulosis Virus (AsGV)
- Wirt
- Hefe
- Protein-Typ
- Recombinant
- Reinheit
- > 90 %
Produktnummer ABIN1608949
2.632,67 €
Zzgl. Versandkosten 20,00 € und MwSt
1 mg
Lieferung nach:
Deutschland
Lieferung in 58 bis 70 Werktagen
Protein
- ELISA (ELISA: Angegebene Anwendung)
- Spezies
- Trichoplusia ni Granulosis Virus (TnGV)
- Wirt
- Hefe
- Protein-Typ
- Recombinant
- Reinheit
- > 90 %
Produktnummer ABIN1609097
2.634,50 €
Zzgl. Versandkosten 20,00 € und MwSt
1 mg
Lieferung nach:
Deutschland
Lieferung in 58 bis 70 Werktagen
Protein
- ELISA (ELISA: Angegebene Anwendung)
- Spezies
- Pieris brassicae Granulosis Virus (PbGV)
- Wirt
- Hefe
- Protein-Typ
- Recombinant
- Reinheit
- > 90 %
Produktnummer ABIN1609063
2.632,67 €
Zzgl. Versandkosten 20,00 € und MwSt
1 mg
Lieferung nach:
Deutschland
Lieferung in 58 bis 70 Werktagen
Protein
- ELISA (ELISA: Angegebene Anwendung)
- Spezies
- Cydia pomonella Granulosis Virus (CpGV)
- Wirt
- Hefe
- Protein-Typ
- Recombinant
- Reinheit
- > 90 %
Produktnummer ABIN1608782
2.634,50 €
Zzgl. Versandkosten 20,00 € und MwSt
1 mg
Lieferung nach:
Deutschland
Lieferung in 58 bis 70 Werktagen
Protein
- ELISA (ELISA: Angegebene Anwendung)
- Spezies
- Ratte
- Wirt
- Hefe
- Protein-Typ
- Recombinant
- Reinheit
- > 90 %
Produktnummer ABIN7584566
1.624,33 €
Zzgl. Versandkosten 20,00 € und MwSt
100 μg
(Weitere Mengeneinheiten)
Lieferung nach:
Deutschland
Lieferung in 58 bis 70 Werktagen
Protein
- ELISA (ELISA: Angegebene Anwendung)
- Spezies
- Xestia c-nigrum Granulosis Virus (XnGV)
- Wirt
- Hefe
- Protein-Typ
- Recombinant
- Reinheit
- > 90 %
Produktnummer ABIN1608450
2.634,50 €
Zzgl. Versandkosten 20,00 € und MwSt
1 mg
Lieferung nach:
Deutschland
Lieferung in 58 bis 70 Werktagen
Protein
- ELISA (ELISA: Angegebene Anwendung)
- Spezies
- Choristoneura fumiferana Granulovirus (CfGV)
- Wirt
- Hefe
- Protein-Typ
- Recombinant
- Reinheit
- > 90 %
Produktnummer ABIN1608475
2.634,50 €
Zzgl. Versandkosten 20,00 € und MwSt
1 mg
Lieferung nach:
Deutschland
Lieferung in 58 bis 70 Werktagen
Produktnummer ABIN1066694
1.950,93 €
Zzgl. Versandkosten 20,00 € und MwSt
100 μg
(Weitere Mengeneinheiten)
Lieferung nach:
Deutschland
Lieferung in 10 bis 12 Werktagen
Protein
- SDS (SDS-PAGE: Angegebene Anwendung)
- WB (Western Blotting: Angegebene Anwendung)
- Imm (Immunogen: Angegebene Anwendung)
- ELISA (ELISA: Angegebene Anwendung)
- Spezies
- Human
- Wirt
- Escherichia coli (E. coli)
- Protein-Typ
- Recombinant
Produktnummer ABIN7946537
503,00 €
Zzgl. Versandkosten 20,00 € und MwSt
100 μg
(Weitere Mengeneinheiten)
Lieferung nach:
Deutschland
Lieferung in 12 bis 17 Werktagen
Aktuelle Publikationen für unsere Granulin Proteine
: "Tumor necrosis factor receptor 2/AKT and ERK signaling pathways contribute to the switch from fibroblasts to CAFs by progranulin in microenvironment of colorectal cancer." in: Oncotarget, Vol. 8, Issue 16, pp. 26323-26333, (2018) (PubMed).
: "CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline. ..." in: EMBO molecular medicine, Vol. 10, Issue 12, (2018) (PubMed).
: "Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 21, pp. 9202-13, (2013) (PubMed).
: "The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding." in: Neurobiology of aging, Vol. 34, Issue 11, pp. 2541-7, (2013) (PubMed).
: "Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival." in: The Journal of cell biology, Vol. 181, Issue 1, pp. 37-41, (2008) (PubMed).
: "CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline. ..." in: EMBO molecular medicine, Vol. 10, Issue 12, (2018) (PubMed).
: "Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 21, pp. 9202-13, (2013) (PubMed).
: "The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding." in: Neurobiology of aging, Vol. 34, Issue 11, pp. 2541-7, (2013) (PubMed).
: "Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival." in: The Journal of cell biology, Vol. 181, Issue 1, pp. 37-41, (2008) (PubMed).
Aliase für Granulin Proteine
granulin precursor (GRN) Proteinegranulin a (grna) Proteine
Granulins (grn) Proteine
granulin L homeolog (grn.L) Proteine
granulin (granulin) Proteine
granulin (ORF1 granulin) Proteine
granulin precursor (Grn) Proteine
granulin (Grn) Proteine
acrogranin Proteine
CLN11 Proteine
DKFZp459H066 Proteine
epithelin Proteine
GEP Proteine
GP88 Proteine
GRN Proteine
grn Proteine
MGC53354 Proteine
PCDGF Proteine
PEPI Proteine
PGRN Proteine
wu:fb11g12 Proteine
wu:fj18f05 Proteine
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