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Human Polyclonal Uchl3 Primary Antibody für IHC (p), WB - ABIN1882147
Saito, Iida, Sekine, Kawauchi, Higuchi, Ogawa, Nakamura: Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population. in Journal of human genetics 2003
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Human Polyclonal Uchl3 Primary Antibody für IHC (p) - ABIN2477032
Mizoi, Takahashi, Yoshimoto, Sugawara, Saito: Surgical excision of giant cerebellar hemispheric arteriovenous malformations following preoperative embolization. Report of two cases. in Journal of neurosurgery 1992
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Human Polyclonal Uchl3 Primary Antibody für IF (p), IHC (p) - ABIN1387243
Wang, Yu, Hu, Cheng, Li: Ubiquitin Carboxy-Terminal HydrolaseL3 Correlates with Human Sperm Count, Motility and Fertilization. in PLoS ONE 2016
Human Monoclonal Uchl3 Primary Antibody für ELISA, WB - ABIN563334
Nogueira da Costa, Mijal, Keen, Findlay, Wild: Proteomic analysis of the effects of the immunomodulatory mycotoxin deoxynivalenol. in Proteomics 2011
The authors find that UCHL3 regulates COPS5 (zeige COPS5 Antikörper)-dependent deneddylation of Cullin1, which is an essential component of SCF (zeige KITLG Antikörper)(beta-TrCP (zeige BTRC Antikörper)) complex and associated with SCF (zeige KITLG Antikörper)(beta-TrCP (zeige BTRC Antikörper)) activities. The authors further demonstrate that UCHL3 upregulates the levels of SCF (zeige KITLG Antikörper)(beta-TrCP (zeige BTRC Antikörper)) substrates including IFN-I receptor IFNAR1 (zeige IFNAR1 Antikörper), which enhances IFN-I mediated signaling pathway and antiviral activity.
Study demonstrated positive correlations between the level and activity of UCHL3 and sperm characteristics and function suggesting that UCHL3 may play a role in male infertility.
Using a series of engineered protein substrates, which are similar in size yet differ in secondary structure, we demonstrate that thermal stability is a key factor that significantly affects UCH-L3 hydrolysis.
UCH-L3 is a novel regulator of epithelial-mesenchymal transition and cell migration in prostate cancer cells.
Data identified of UCHL3 as an essential deubiquitinase in adipogenesis.
impaired UCH-L3 function may contribute to the accumulation of full length UBB (zeige UBB Antikörper)(+1) in various pathologie
1.45 A resolution crystal structure of human UCH-L3 in complex with the inhibitor ubiquitin vinylmethylester, an inhibitor that forms a covalent adduct with the active site cysteine of ubiquitin-specific proteases
Upregulation of UCH-L3 is associated with Uterine Cervical Neoplasms
Substrate filtering by the active site crossover loop in UCHL3 revealed by sortagging and gain-of-function mutations.
These results indicate that mono-Ub and Ub dimers may regulate the enzymatic functions of UCH-L1 (zeige UCHL1 Antikörper) and UCH-L3, respectively, in vivo.
Data suggest that the activity of oocyte UCHL-1 (zeige UCHL1 Antikörper) and -3 contributes to oocyte maturation by regulating the oocyte cortex and meiotic spindle.
subfertile Uchl1(gad-/-) mutant mice showed an intriguing pattern of switched UCH localization, with UCHL3 replacing UCHL1 (zeige UCHL1 Antikörper) in the oocyte cortex
impaired UCH-L3 function may contribute to the accumulation of full length UBB (zeige UBA52 Antikörper)(+1) in various pathologie
Results suggest that Uch-L3 enhances osteoblast differentiation through the stabilization of Smad1 (zeige SMAD1 Antikörper) signaling
Polyubiquitinated proteins accumulate in skeletal muscle as well as in mouse embryonic fibroblasts derived from Uchl3-deficient mice.
Results suggest that UCH-L3 promotes adipogenesis by enhancing insulin (zeige INS Antikörper) signaling in a hydrolase activity-dependent manner.
The role of ubiquitin C-terminal hydrolase (zeige UCHL1 Antikörper) (UCH)-L3 in the regulation of AMP-activated protein kinase (zeige PRKAA2 Antikörper) activity and whole-body energy metabolism are reportedl
UCH-L3 regulates the apical membrane recycling of the epithelial sodium channel
Data show that Uchl3 and mitofilin are differentially expressed in the hippocampi of inbred senescence-acclerated mice compared to normally-aging mice.
swine UCHL3, RIT1 (zeige RIT1 Antikörper) and CCND3 (zeige CCND3 Antikörper) genes were differentially expressed in tissues including small intestine, large intestine, liver, muscle, fat, lung, spleen and kidney
The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family are proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the mechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to regenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
ubiquitin carboxyl-terminal hydrolase isozyme L3
, ubiquitin thioesterase L3
, ubiquitin thiolesterase
, ubiquitin carboxyl-terminal hydrolase-6
, ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
, ubiquitin carboxyl-terminal esterase L4