Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

ErbB2/Her2 Proteine

(Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].

59 Treffer :

ErbB2/Her2 Spezies: Human Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Produktnummer ABIN7274799
 
ErbB2/Her2 Spezies: Human Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Produktnummer ABIN7274796
 
ErbB2/Her2 Spezies: Human Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Produktnummer ABIN7274800
 
ErbB2/Her2 Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Pubmed 15 Referenzen
Produktnummer ABIN2181214
 
ErbB2/Her2 Spezies: Cynomolgus Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Produktnummer ABIN7274794
 
ErbB2/Her2 Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AA, AP
Pubmed 2 Referenzen
Produktnummer ABIN1353011
 
ErbB2/Her2 Spezies: Human Wirt: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Produktnummer ABIN6964074
 
ErbB2/Her2 Spezies: Human Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Produktnummer ABIN7274804
 
ErbB2/Her2 Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Pubmed 2 Referenzen
Produktnummer ABIN2181216
 
ErbB2/Her2 Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Pubmed 2 Referenzen
Produktnummer ABIN6809903
 
ErbB2/Her2 Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Produktnummer ABIN7013682
 
ErbB2/Her2 Spezies: Human Wirt: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Pubmed 1 reference
Produktnummer ABIN5954984
 
ErbB2/Her2 Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE. Active
Pubmed 2 Referenzen
Produktnummer ABIN2444140
 
ErbB2/Her2 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Produktnummer ABIN7124801
 
ErbB2/Her2 Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AA, AP
Produktnummer ABIN1353013
 
ErbB2/Her2 Spezies: Ratte Wirt: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
Produktnummer ABIN7321222
 
ErbB2/Her2 Spezies: Ratte Wirt: HEK-293 Cells Recombinant > 85 % as determined by SDS-PAGE
Produktnummer ABIN7321223
 
ErbB2/Her2 Spezies: Maus Wirt: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
Produktnummer ABIN7319994
 
ErbB2/Her2 Spezies: Human Wirt: Baculovirus infected Insect Cells Recombinant > 85% by SDS-PAGE SDS
Produktnummer ABIN7281248
 
ErbB2/Her2 Spezies: Ratte Wirt: HEK-293 Cells Recombinant > 92 % as determined by SDS-PAGE Active
Produktnummer ABIN7321221
 
  • Typ Protein
    • Protein
  • Anwendung
    • Western Blotting (WB)
    • SDS-PAGE (SDS)
    • ELISA
    • Immunogen (Imm)
    • Positive Control (PC)
    • Antibody Production (AbP)
    • Standard (STD)
    • Affinity Purification (AP)
    • Antibody Array (AA)
    • Activity Assay (AcA)
    • Enzyme Immunoassay (EIA)
    • Functional Studies (Func)
  • Reaktivität
    • Human
    • Rat
    • Mouse
    • Cynomolgus
    • Rabbit
  • In Publikationen zitiert
  • Abbildungen verfügbar
  • Preservative free only
  • Carrier free only
  • Wirt
    • HEK-293 Cells
    • Escherichia coli (E. coli)
    • Mammalian Cells
    • Wheat germ
    • Baculovirus infected Insect Cells
    • Human Cells
    • Insect Cells
    • Insect cells (Sf9)
    • Yeast
  • Bindungsspezifität
    • AA 23-652
    • Transcript Variant 1
    • AA 1-1255
    • AA 120-749
    • AA 153-598
    • AA 22-121
    • AA 23-372
    • AA 23-510
    • AA 23-653
    • AA 23-654
    • AA 376-578
    • AA 377-579
    • AA 380-582
    • AA 4-656
    • AA 489-630
    • AA 498-648
    • AA 511-630
    • AA 67-323
    • Extracellular
    • Transcript Variant 2
    • partial
  • Konjugat
    • His tag
    • Fc Tag
    • Unkonjugiert
    • GST tag
    • His tag,AVI tag,Biotin
    • His tag,GST tag
    • His-Avi Tag,Biotin
    • Myc-DYKDDDDK Tag
    • APC,His tag
    • Alexa Fluor 488,His tag
    • Alexa Fluor 555,His tag
    • Alexa Fluor 647,His tag
    • Biotin
    • DYKDDDDK Tag
    • DYKDDDDK-His Tag
    • FITC,Fc Tag
    • Fc Tag,His tag
    • His tag,Biotin
    • His tag,FITC
    • His tag,PE
    • His-Avi Tag
    • PE,His tag
    • Strep Tag
  • Protein-Typ
    • Recombinant
  • Format
    • Lyophilized
    • Liquid
  • Biologische Aktivität
    • Biologically Active
  • Hersteller
    • antibodies-online
    • ACROBiosystems
    • OriGene
    • Signalway
    • CUSABIO
    • FabGennix
    • ProSci

Aktuelle Publikationen für unsere ErbB2/Her2 Proteine

Farràs, Román, Camps, Miret, Martínez, Pujol, Casablancas, Cairó: "Heavy chain dimers stabilized by disulfide bonds are required to promote in vitro assembly of trastuzumab." in: BMC molecular and cell biology, Vol. 21, Issue 1, pp. 2, (2020) (PubMed).

Murakami, Matsumoto, Kanamori: "Constructive approach for synthesis of a functional IgG using a reconstituted cell-free protein synthesis system." in: Scientific reports, Vol. 9, Issue 1, pp. 671, (2020) (PubMed).

Hao, Yu, Bai, McBride, Huang: "Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex." in: PLoS ONE, Vol. 14, Issue 5, pp. e0216095, (2020) (PubMed).

Turner, Kilgour, Stine, Daniele, Menegatti: "Dual-Affinity Ratiometric Quenching (DARQ) Assay for the Quantification of Therapeutic Antibodies in CHO-S Cell Culture Fluids." in: Analytical chemistry, Vol. 92, Issue 24, pp. 16274-16283, (2020) (PubMed).

Hutterer, Polozova, Kuhns, McBride, Cao, Liu: "Assessing Analytical and Functional Similarity of Proposed Amgen Biosimilar ABP 980 to Trastuzumab." in: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, Vol. 33, Issue 3, pp. 321-333, (2019) (PubMed).

Hussack, Raphael, Lowden, Henry: "Isolation and characterization of camelid single-domain antibodies against HER2." in: BMC research notes, Vol. 11, Issue 1, pp. 866, (2019) (PubMed).

Shinozaki, Hashimoto, Fukui, Uchiyama: "Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities." in: Scientific reports, Vol. 7, Issue 1, pp. 5794, (2019) (PubMed).

Wang, Forterre, Zhao, Frimannsson, Delcayre, Antes, Efron, Jeffrey, Pegram, Matin: "Anti-HER2 scFv-Directed Extracellular Vesicle-Mediated mRNA-Based Gene Delivery Inhibits Growth of HER2-Positive Human Breast Tumor Xenografts by Prodrug Activation." in: Molecular cancer therapeutics, Vol. 17, Issue 5, pp. 1133-1142, (2019) (PubMed).

Mortensen, Skovsgaard, Okholm, Scavenius, Dupont, Rosen, Enghild, Kjems, Gothelf: "Small-Molecule Probes for Affinity-Guided Introduction of Biocompatible Handles on Metal-Binding Proteins." in: Bioconjugate chemistry, Vol. 29, Issue 9, pp. 3016-3025, (2019) (PubMed).

Vivier, Sharma, Adumeau, Rodriguez, Fung, Zeglis: "The Impact of FcγRI Binding on ImmunoPET." in: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, (2019) (PubMed).

Aliase für ErbB2/Her2 Proteine

erb-b2 receptor tyrosine kinase 2 (ERBB2) Proteine
erb-b2 receptor tyrosine kinase 2 (Erbb2) Proteine
erb-b2 receptor tyrosine kinase 2 (erbb2) Proteine
c-erbB2 Proteine
c-neu Proteine
CD340 Proteine
erb2 Proteine
Erbb-2 Proteine
HER-2 Proteine
HER-2/neu Proteine
HER2 Proteine
mKIAA3023 Proteine
MLN 19 Proteine
NEU Proteine
Neu Proteine
NGL Proteine
TKR1 Proteine
wu:fv70f10 Proteine
zgc:63601 Proteine
Sie sind hier:
Chat with us!