ErbB2/Her2 Proteine
(Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].
| Catalog no. | Produkt | Reaktivität | Wirt / Klonalität | Anwendung | Preis & Lieferzeit |
|---|---|---|---|---|---|
| ErbB2/Her2 Protein (L755S) (GST tag) | Human | Baculovirus infected Insect Cells |
|
425,54 €
Preis anzeigen
|
|
| ErbB2/Her2 Protein (L755W) (GST tag) | Human | Baculovirus infected Insect Cells |
|
425,54 €
Preis anzeigen
|
|
| ErbB2/Her2 Protein (T798I) (GST tag) | Human | Baculovirus infected Insect Cells |
|
425,54 €
Preis anzeigen
|
|
| ErbB2/Her2 Protein (I767M) (GST tag) | Human | Baculovirus infected Insect Cells |
|
425,54 €
Preis anzeigen
|
|
| ErbB2/Her2 Protein (His tag) | Human | Baculovirus infected Insect Cells |
|
436,31 €
Preis anzeigen
|
|
| ErbB2/Her2 Protein (C805S) (GST tag) | Human | Baculovirus infected Insect Cells |
|
436,31 €
Preis anzeigen
|
|
| ErbB2/Her2 Protein (GST tag) | Human | Baculovirus infected Insect Cells |
|
436,31 €
Preis anzeigen
|
|
| ErbB2/Her2 Protein (His-Avi Tag,Biotin) | Human | HEK-293 Cells |
|
966,73 €
Preis anzeigen
|
|
| ErbB2/Her2 Protein (AA 511-644) (His tag) | Human | Escherichia coli (E. coli) |
|
1.974,03 €
Preis anzeigen
|
|
| ErbB2/Her2 Protein (Fc Tag,His tag) | Maus | HEK-293 Cells |
|
340,00 €
Preis anzeigen
|
|
| ErbB2/Her2 Protein (His-Avi Tag,Biotin) | Human | HEK-293 Cells |
|
966,73 €
Preis anzeigen
|
|
| ErbB2/Her2 Protein (AA 23-654) (His tag) | Ratte | Mammalian Cells |
|
615,38 €
Preis anzeigen
|
|
| ErbB2/Her2 Protein (AA 120-749) (His tag) | Cynomolgus | HEK-293 Cells |
|
872,31 €
Preis anzeigen
|
|
| ErbB2/Her2 Protein | Human | HEK-293 Cells |
|
9.582,95 €
Preis anzeigen
|
|
| ErbB2/Her2 Protein (AA 23-652) (Fc-Avi Tag,Biotin) | Human | Human Cells |
|
987,96 €
Preis anzeigen
|
|
| ErbB2/Her2 Protein (His tag) | Human | HEK-293 Cells |
|
746,00 €
Preis anzeigen
|
|
| ErbB2/Her2 Protein (AA 67-323) (His tag) | Ratte | Escherichia coli (E. coli) |
|
287,60 €
Preis anzeigen
|
|
| ErbB2/Her2 Protein (GST tag) | Human | Insektenzellen |
|
420,00 €
Preis anzeigen
|
|
| ErbB2/Her2 Protein (AA 376-578) (His tag,GST tag) | Human | Escherichia coli (E. coli) |
|
687,38 €
Preis anzeigen
|
|
| ErbB2/Her2 Protein (AA 380-582) (His tag,GST tag) | Ratte | Escherichia coli (E. coli) |
|
748,43 €
Preis anzeigen
|
Protein
- KAA (Kinase Activity Assay: Angegebene Anwendung)
- Spezies
- Human
- Wirt
- Baculovirus infected Insect Cells
- Protein-Typ
- Recombinant
Produktnummer ABIN7856278
425,54 €
Zzgl. Versandkosten 20,00 €, Trockeneispauschale 20,00 € sowie MwSt
10 μg
Lieferung nach:
Deutschland
Lieferung in 8 bis 12 Werktagen
Protein
- KAA (Kinase Activity Assay: Angegebene Anwendung)
- Spezies
- Human
- Wirt
- Baculovirus infected Insect Cells
- Protein-Typ
- Recombinant
Produktnummer ABIN7856280
425,54 €
Zzgl. Versandkosten 20,00 €, Trockeneispauschale 20,00 € sowie MwSt
10 μg
Lieferung nach:
Deutschland
Lieferung in 8 bis 12 Werktagen
Protein
- KAA (Kinase Activity Assay: Angegebene Anwendung)
- Spezies
- Human
- Wirt
- Baculovirus infected Insect Cells
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
Produktnummer ABIN7856283
425,54 €
Zzgl. Versandkosten 20,00 €, Trockeneispauschale 20,00 € sowie MwSt
10 μg
Lieferung nach:
Deutschland
Lieferung in 8 bis 12 Werktagen
Protein
- KAA (Kinase Activity Assay: Angegebene Anwendung)
- Spezies
- Human
- Wirt
- Baculovirus infected Insect Cells
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
Produktnummer ABIN7856277
425,54 €
Zzgl. Versandkosten 20,00 €, Trockeneispauschale 20,00 € sowie MwSt
10 μg
Lieferung nach:
Deutschland
Lieferung in 8 bis 12 Werktagen
Protein
- Spezies
- Human
- Wirt
- Baculovirus infected Insect Cells
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
Produktnummer ABIN7856287
436,31 €
Zzgl. Versandkosten 20,00 €, Trockeneispauschale 20,00 € sowie MwSt
10 μg
Lieferung nach:
Deutschland
Lieferung in 8 bis 12 Werktagen
Protein
- KAA (Kinase Activity Assay: Angegebene Anwendung)
- Spezies
- Human
- Wirt
- Baculovirus infected Insect Cells
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
Produktnummer ABIN7856271
436,31 €
Zzgl. Versandkosten 20,00 €, Trockeneispauschale 20,00 € sowie MwSt
10 μg
Lieferung nach:
Deutschland
Lieferung in 8 bis 12 Werktagen
Protein
- Spezies
- Human
- Wirt
- Baculovirus infected Insect Cells
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
Produktnummer ABIN7856288
436,31 €
Zzgl. Versandkosten 20,00 €, Trockeneispauschale 20,00 € sowie MwSt
10 μg
Lieferung nach:
Deutschland
Lieferung in 8 bis 12 Werktagen
Protein
- Spezies
- Human
- Wirt
- HEK-293 Cells
- Protein-Typ
- Recombinant
- Reinheit
- >95 % , as determined by SDS-PAGE and HPLC
Produktnummer ABIN7865938
966,73 €
Zzgl. Versandkosten 20,00 € und MwSt
50 μg
Lieferung nach:
Deutschland
Lieferung in 6 bis 7 Werktagen
Protein
- Spezies
- Human
- Wirt
- Escherichia coli (E. coli)
- Protein-Typ
- Recombinant
Produktnummer ABIN7890164
1.974,03 €
Zzgl. Versandkosten 20,00 € und MwSt
1 mg
Lieferung nach:
Deutschland
Lieferung in 8 bis 10 Werktagen
Protein
- Spezies
- Maus
- Wirt
- HEK-293 Cells
- Protein-Typ
- Recombinant
- Reinheit
- > 97 % by SDS-PAGE.
- Biologische Aktivität
- Active
Produktnummer ABIN7534934
340,00 €
Zzgl. Versandkosten 20,00 € und MwSt
100 μg
(Weitere Mengeneinheiten)
Lieferung nach:
Deutschland
Lieferung in 7 bis 9 Werktagen
Protein
- Spezies
- Human
- Wirt
- HEK-293 Cells
- Protein-Typ
- Recombinant
- Reinheit
- >95 % , as determined by SDS-PAGE and HPLC
Produktnummer ABIN7865937
966,73 €
Zzgl. Versandkosten 20,00 € und MwSt
50 μg
Lieferung nach:
Deutschland
Lieferung in 6 bis 7 Werktagen
Protein
- WB (Western Blotting: Angegebene Anwendung)
- ELISA (ELISA: Angegebene Anwendung)
- Spezies
- Ratte
- Wirt
- Mammalian Cells
- Protein-Typ
- Recombinant
- Reinheit
- Greater than 90 % as determined by SDS-PAGE.
Produktnummer ABIN7665224
615,38 €
Zzgl. Versandkosten 20,00 € und MwSt
50 μg
(Weitere Mengeneinheiten)
Lieferung nach:
Deutschland
Lieferung in 13 bis 18 Werktagen
Protein
- ScA (Screening Assay: Angegebene Anwendung)
- AM (Affinity Measurement: Angegebene Anwendung)
- ADA (Antibody Drug Assay: Angegebene Anwendung)
- IA (Immunoassay: Angegebene Anwendung)
- Spezies
- Cynomolgus
- Wirt
- HEK-293 Cells
- Protein-Typ
- Recombinant
- Reinheit
- The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Produktnummer ABIN7853134
872,31 €
Zzgl. Versandkosten 20,00 € und MwSt
100 μg
(Weitere Mengeneinheiten)
Lieferung nach:
Deutschland
Lieferung in 10 bis 13 Werktagen
Protein
- EIA (Enzyme Immunoassay: Angegebene Anwendung)
- Spezies
- Human
- Wirt
- HEK-293 Cells
- Protein-Typ
- Recombinant
- Reinheit
- > 95 %
Produktnummer ABIN7385953
9.582,95 €
Zzgl. Versandkosten 20,00 € und MwSt
1 mg
Lieferung nach:
Deutschland
Lieferung in 7 bis 10 Werktagen
Protein
- Spezies
- Human
- Wirt
- Human Cells
- Protein-Typ
- Recombinant
Produktnummer ABIN7890165
987,96 €
Zzgl. Versandkosten 20,00 € und MwSt
100 μg
Lieferung nach:
Deutschland
Lieferung in 8 bis 10 Werktagen
Protein
- ELISA (ELISA: Angegebene Anwendung)
- Spezies
- Human
- Wirt
- HEK-293 Cells
- Protein-Typ
- Recombinant
- Reinheit
- > 90 % as determined by reducing SDS-PAGE.
- Biologische Aktivität
- Active
Produktnummer ABIN7197648
746,00 €
Zzgl. Versandkosten 20,00 € und MwSt
100 μg
(Weitere Mengeneinheiten)
Lieferung nach:
Deutschland
Lieferung in 9 bis 13 Werktagen
Protein
- Spezies
- Ratte
- Wirt
- Escherichia coli (E. coli)
- Protein-Typ
- Recombinant
- Reinheit
- > 95 % as determined by reducing SDS-PAGE.
Produktnummer ABIN7321265
287,60 €
Zzgl. Versandkosten 20,00 € und MwSt
50 μg
(Weitere Mengeneinheiten)
Lieferung nach:
Deutschland
Lieferung in 9 bis 13 Werktagen
Protein
- Func (Functional Studies: Angegebene Anwendung)
- Spezies
- Human
- Wirt
- Insektenzellen
- Protein-Typ
- Recombinant
- Reinheit
- 70 % - 90 %
Produktnummer ABIN5508954
420,00 €
Zzgl. Versandkosten 20,00 € und MwSt
10 μg
Lieferung nach:
Deutschland
Lieferung in 15 bis 27 Werktagen
Protein
- WB (Western Blotting: Angegebene Anwendung)
- SDS (SDS-PAGE: Angegebene Anwendung)
- Imm (Immunogen: Angegebene Anwendung)
- PC (Positive Control: Angegebene Anwendung)
- Spezies
- Human
- Wirt
- Escherichia coli (E. coli)
- Protein-Typ
- Recombinant
- Reinheit
- > 95 %
Produktnummer ABIN7395074
687,38 €
Zzgl. Versandkosten 20,00 € und MwSt
100 μg
(Weitere Mengeneinheiten)
Lieferung nach:
Deutschland
Lieferung in 11 bis 15 Werktagen
Protein
- WB (Western Blotting: Angegebene Anwendung)
- SDS (SDS-PAGE: Angegebene Anwendung)
- Imm (Immunogen: Angegebene Anwendung)
- PC (Positive Control: Angegebene Anwendung)
- Spezies
- Ratte
- Wirt
- Escherichia coli (E. coli)
- Protein-Typ
- Recombinant
- Reinheit
- > 97 %
Produktnummer ABIN7395080
748,43 €
Zzgl. Versandkosten 20,00 € und MwSt
100 μg
(Weitere Mengeneinheiten)
Lieferung nach:
Deutschland
Lieferung in 11 bis 15 Werktagen
Aktuelle Publikationen für unsere ErbB2/Her2 Proteine
: "Heavy chain dimers stabilized by disulfide bonds are required to promote in vitro assembly of trastuzumab." in: BMC molecular and cell biology, Vol. 21, Issue 1, pp. 2, (2020) (PubMed).
: "Constructive approach for synthesis of a functional IgG using a reconstituted cell-free protein synthesis system." in: Scientific reports, Vol. 9, Issue 1, pp. 671, (2020) (PubMed).
: "Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex." in: PLoS ONE, Vol. 14, Issue 5, pp. e0216095, (2020) (PubMed).
: "Dual-Affinity Ratiometric Quenching (DARQ) Assay for the Quantification of Therapeutic Antibodies in CHO-S Cell Culture Fluids." in: Analytical chemistry, Vol. 92, Issue 24, pp. 16274-16283, (2020) (PubMed).
: "Assessing Analytical and Functional Similarity of Proposed Amgen Biosimilar ABP 980 to Trastuzumab." in: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, Vol. 33, Issue 3, pp. 321-333, (2019) (PubMed).
: "Isolation and characterization of camelid single-domain antibodies against HER2." in: BMC research notes, Vol. 11, Issue 1, pp. 866, (2019) (PubMed).
: "Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities." in: Scientific reports, Vol. 7, Issue 1, pp. 5794, (2019) (PubMed).
: "Anti-HER2 scFv-Directed Extracellular Vesicle-Mediated mRNA-Based Gene Delivery Inhibits Growth of HER2-Positive Human Breast Tumor Xenografts by Prodrug Activation." in: Molecular cancer therapeutics, Vol. 17, Issue 5, pp. 1133-1142, (2019) (PubMed).
: "Small-Molecule Probes for Affinity-Guided Introduction of Biocompatible Handles on Metal-Binding Proteins." in: Bioconjugate chemistry, Vol. 29, Issue 9, pp. 3016-3025, (2019) (PubMed).
: "The Impact of FcγRI Binding on ImmunoPET." in: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, (2019) (PubMed).
: "Constructive approach for synthesis of a functional IgG using a reconstituted cell-free protein synthesis system." in: Scientific reports, Vol. 9, Issue 1, pp. 671, (2020) (PubMed).
: "Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex." in: PLoS ONE, Vol. 14, Issue 5, pp. e0216095, (2020) (PubMed).
: "Dual-Affinity Ratiometric Quenching (DARQ) Assay for the Quantification of Therapeutic Antibodies in CHO-S Cell Culture Fluids." in: Analytical chemistry, Vol. 92, Issue 24, pp. 16274-16283, (2020) (PubMed).
: "Assessing Analytical and Functional Similarity of Proposed Amgen Biosimilar ABP 980 to Trastuzumab." in: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, Vol. 33, Issue 3, pp. 321-333, (2019) (PubMed).
: "Isolation and characterization of camelid single-domain antibodies against HER2." in: BMC research notes, Vol. 11, Issue 1, pp. 866, (2019) (PubMed).
: "Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities." in: Scientific reports, Vol. 7, Issue 1, pp. 5794, (2019) (PubMed).
: "Anti-HER2 scFv-Directed Extracellular Vesicle-Mediated mRNA-Based Gene Delivery Inhibits Growth of HER2-Positive Human Breast Tumor Xenografts by Prodrug Activation." in: Molecular cancer therapeutics, Vol. 17, Issue 5, pp. 1133-1142, (2019) (PubMed).
: "Small-Molecule Probes for Affinity-Guided Introduction of Biocompatible Handles on Metal-Binding Proteins." in: Bioconjugate chemistry, Vol. 29, Issue 9, pp. 3016-3025, (2019) (PubMed).
: "The Impact of FcγRI Binding on ImmunoPET." in: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, (2019) (PubMed).
Aliase für ErbB2/Her2 Proteine
erb-b2 receptor tyrosine kinase 2 (ERBB2) Proteineerb-b2 receptor tyrosine kinase 2 (Erbb2) Proteine
erb-b2 receptor tyrosine kinase 2 (erbb2) Proteine
c-erbB2 Proteine
c-neu Proteine
CD340 Proteine
erb2 Proteine
Erbb-2 Proteine
HER-2 Proteine
HER-2/neu Proteine
HER2 Proteine
mKIAA3023 Proteine
MLN 19 Proteine
NEU Proteine
Neu Proteine
NGL Proteine
TKR1 Proteine
wu:fv70f10 Proteine
zgc:63601 Proteine
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