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anti-Human XBP1 Antikörper:
anti-Mouse (Murine) XBP1 Antikörper:
anti-Rat (Rattus) XBP1 Antikörper:
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Human Polyclonal XBP1 Primary Antibody für ChIP, IHC - ABIN256411
Bogaert, De Vos, Olievier, Peeters, Elewaut, Lambrecht, Pouliot, Laukens: Involvement of endoplasmic reticulum stress in inflammatory bowel disease: a different implication for colonic and ileal disease? in PLoS ONE 2011
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Human Monoclonal XBP1 Primary Antibody für ELISA, WB - ABIN969462
Martino, Olsen, Fulcher, Wolfgang, ONeal, Ribeiro: Airway epithelial inflammation-induced endoplasmic reticulum Ca2+ store expansion is mediated by X-box binding protein-1. in The Journal of biological chemistry 2009
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Human Monoclonal XBP1 Primary Antibody für ELISA, WB - ABIN967263
Jiang, Yang, Thorne, Zhu, Hersey, Zhang: Human melanoma cells under endoplasmic reticulum stress acquire resistance to microtubule-targeting drugs through XBP-1-mediated activation of Akt. in Neoplasia (New York, N.Y.) 2009
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Human Polyclonal XBP1 Primary Antibody für ICC, IF - ABIN4366342
Baek, Kim, Park, Jang, Kang, Lee, Moon, Chae, Chung: Involvement of endoplasmic reticulum stress in myofibroblastic differentiation of lung fibroblasts. in American journal of respiratory cell and molecular biology 2012
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Human Polyclonal XBP1 Primary Antibody für ELISA, ICC - ABIN4366344
Park, Shin, Lim, Lee, Kang: Purple perilla extracts allay ER stress in lipid-laden macrophages. in PLoS ONE 2014
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Human Polyclonal XBP1 Primary Antibody für IF (p), IHC (p) - ABIN732728
Li, Han, Shi: IRE1?-XBP1 Pathway Is Activated Upon Induction of Single-Prolonged Stress in Rat Neurons of the Medial Prefrontal Cortex. in Journal of molecular neuroscience : MN 2015
Human Polyclonal XBP1 Primary Antibody für ICC, IF - ABIN4366347
Ciccia, Accardo-Palumbo, Rizzo, Guggino, Raimondo, Giardina, Cannizzaro, Colbert, Alessandro, Triolo: Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation. in Annals of the rheumatic diseases 2014
Human Monoclonal XBP1 Primary Antibody für CyTOF, FACS - ABIN4899365
Hasegawa, Wendling, He, Trilisky, Stevenson, Franey, Kinderman, Li, Piedmonte, Osslund, Shen, Ketchem: In vivo crystallization of human IgG in the endoplasmic reticulum of engineered Chinese hamster ovary (CHO) cells. in The Journal of biological chemistry 2011
XBP1s transcriptionally activated Kalirin (zeige KALRN Antikörper)-7 (Kal7), a protein that controls synaptic plasticity. Authors found reduced levels of Kal7 in primary neurons exposed to Abeta (zeige APP Antikörper) oligomers, transgenic mouse models and human AD brains.
XBP1 decreased glucose dysfunction via funneling its effects on improving insulin (zeige INS Antikörper) sensitivity and stimulating insulin (zeige INS Antikörper) secretion. However, XBP1 also yields its double-edged effects, driving the transformation from excess glucose to lipid, which is a key contribution to obesity and Diabetes Mellitus, Type 2. [review]
IRE1alpha (zeige ERN1 Antikörper)-XBP1 pathway regulates Mel (zeige RAB8A Antikörper)-RMu cell proliferation and progression by activating IL-6 (zeige IL6 Antikörper)/STAT3 (zeige STAT3 Antikörper) signaling.
XBP1 expression correlated with the poor overall survival of patients; XBP1-mediated beta-catenin (zeige CTNNB1 Antikörper) bladder cancer expression can be targeted with new synthetic Oridonin analogues
Data suggest a central role of XBP1 in TLR7 (zeige TLR7 Antikörper)-induced IFNalpha production and identify XBP1 as a potential novel therapeutic target in IFNalpha-driven autoimmune and inflammatory diseases.
the XBP1u nascent chain is transferred from the signal recognition particle to the translocon; however, it cannot pass through the translocon or insert into the membrane.
The biologic processes altered by aberrant IRE1alpha (zeige ERN1 Antikörper)-XBP1 signaling in these innate immune cells.
MiR (zeige MLXIP Antikörper)-665 induced apoptosis by inhibiting XBP1 and ORMDL3 (zeige ORMDL3 Antikörper).
IRE1alpha (zeige ERN1 Antikörper) was shown to cleave miR (zeige MLXIP Antikörper)-150 and thereby to release the suppressive effect that miR (zeige MLXIP Antikörper)-150 exerted on alphaSMA (zeige ACTA2 Antikörper) expression through c-Myb (zeige MYB Antikörper). Inhibition of IRE1alpha (zeige ERN1 Antikörper) was also demonstrated to block endoplasmic reticulum expansion through an XBP-1-dependent pathway.
mTORC2 (zeige CRTC2 Antikörper) responds to glutamine (zeige GFPT1 Antikörper) catabolite levels to modulate the hexosamine biosynthesis enzyme GFAT1 (zeige GFPT1 Antikörper), and is essential for proper expression and nuclear accumulation of the GFAT1 (zeige GFPT1 Antikörper) transcriptional regulator, Xbp1s.
ER stress is induced early in EAE and that modulation of ER stress by inhibition of eIF2alpha (zeige EIF2A Antikörper)-CHOP (zeige DDIT3 Antikörper) and activation of XBP-1 in RGC specifically, protects RGC somata and axons and preserves visual function.
one of the antioxidant enzymes, Prdx-2 (zeige PRDX2 Antikörper), was abundantly nitrosylated and temporarily reduced in antioxidant activity, causing transient endogenous hydrogen peroxide (H2O2) accumulation and subsequent X-box binding protein-1s/phosphatidylinositol 3-kinase pathway activation.Prdx-2 nitrosylation could be a potent strategy to affect the pluripotent stem cell-derived cardiomyogenesis.
XBP1 deficiency in smooth muscle cells caused VSMC dedifferentiation and aggravated aortic aneurysms. XBP1u directly associated with the N terminus of FoxO4 (zeige FOXO4 Antikörper).
Data show that LPS (zeige TLR4 Antikörper) induces endoplasmic reticulum (ER) stress and P300 (zeige NOTCH1 Antikörper) activity via the XBP1/IRE1 (zeige ERN1 Antikörper) pathway.
Data suggest that activation of GRP78 (zeige HSPA5 Antikörper)/Ire1 (zeige ERN1 Antikörper)/Xbp1 pathway of ER stress-unfolded protein response is involved in mouse decidualization.
insulin (zeige INS Antikörper) and aPC (zeige APC Antikörper) converge on a common spliced-X-box binding protein-1 (sXBP1) signaling pathway to maintain endoplasmic reticulum (ER) homeostasis.
although feeding LS-Xbp1(-/-) mice cholesterol did not increase CYP7A1 (zeige CYP7A1 Antikörper) expression, serum C4 levels increased significantly up to levels similar to chow-fed Xbp1(fl/fl (zeige FLT3LG Antikörper)) mice and the total bile acid pool normalized. In conclusion, loss of hepatic XBP1 decreased the bile acid pool and CYP7A1 (zeige CYP7A1 Antikörper) synthetic activity.
The findings indicate that IRE1 (zeige ERN1 Antikörper)-XBP1 downregulation distinguishes germinal center B-cell-like diffuse large B-cell lymphoma (DLBCL) from other DLBCL subtypes and contributes to tumor growth.
analyzed XBP1 level and location to explore the effect of ER stress on oocyte maturation and developmental competency of porcine embryos in an in vitro culture system
Knock-down of XBP1 enhanced endoplasmic reticulum stress-mediated cell death in porcine embryonic fibroblasts.
Exposure of endothelial cells to VEGF (zeige VEGFA Antikörper), high glucose, or hydrogen peroxide up-regulated the XBP1/IRE1 alpha (zeige ERN1 Antikörper) and ATF6 (zeige ATF6 Antikörper) arms of the unfolded protein response compared with untreated cells.
Expression of xbp1 is significantly upregulated in the liver of Cdipt (zeige CDIPT Antikörper)-deficient zebrafish due to persistent endoplasmic reticulum stress. Cdipt (zeige CDIPT Antikörper)-deficient zebrafish exhibits hepatic lipid accumulation.
zebrafish XBP-1 spliced form not only activates genes responsible for protein folding, transporting, glycosylation and Endoplasmic Reticulum associated degradation but also activates anti-apoptosis signal via IGF1 (zeige IGF1 Antikörper)/Akt (zeige AKT1 Antikörper) pathway in unfolded protein
XBP1 might function as an inhibitor of mesodermal and neural tissue formation by acting either as transcriptional activator or as repressor.
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.
X-box binding protein 1 pseudogene 1
, X-box binding protein pseudogene 1
, X-box binding protein 1
, X-box-binding protein 1
, tax-responsive element-binding protein 5
, tax-responsive element-binding protein 5 homolog
, hepatocarcinogenesis-related transcription factor
, X-box binding protein 1B