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physiological function of Pde1c in Drosophila melanogaster
The Drosophila genome encodes five novel PDE genes in addition to dunce. Predicted PDE sequences of Drosophila show highly conserved critical domains when compared with human PDEs.
Cardiac Pde1C is a direct transcriptional target of PPARalpha.
Ligation injury caused a marked increase in neointimal and medial thickening in PDE1C+/+ mice. Injury-induced neointimal formation was significantly attenuated by PDE1C deficiency (knockout mice) or PDE1 inhibition in vivo.
PDE1C is expressed in isolated juxtaglomerular cells, and contributes to calcium's inhibitory modulation of renin release from juxtaglomerular cells.
PDE1C is a proliferation-associated gene in glioblastoma multiforme cells in vitro.
PDE1C is an important regulator of SMC proliferation, migration, and neointimal hyperplasia, in part through modulating endosome/lysosome-dependent PDGFRbeta protein degradation via low-density lipoprotein receptor-related protein-1.
PDE1C levels decreased in all conditions that inhibited proliferation
PDE1C1 is expressed at high levels in human cardiac myocytes with an intracellular distribution distinct from that of PDE3A
Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been classified into several families based on their biochemical properties. Members of the PDE1 family, such as PDE1C, are calmodulin (see MIM 114180)-dependent PDEs (CaM-PDEs) that are stimulated by a calcium-calmodulin complex (Repaske et al., 1992
, phosphodiesterase 1c
, phosphodiesterase 1C, calmodulin-dependent 70kDa
, calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
, calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C-like
, cam-PDE 1C
, cyclic nucleotide phosphodiesterase 1 C
, phosphodiesterase 1C calmodulin-dependent (70kD)
, Human 3',5' cyclic nucleotide phosphodiesterase (HSPDE1C1A)