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Found that the calcium-modulating cyclophilin ligand (CAMLG), which is involved in Ca(2+) signaling, was the major host cell PilA binding protein.
A novel interaction between calcium-modulating cyclophilin ligand and Basigin regulates calcium signaling and matrix metalloproteinase activities in human melanoma cells.
Results indicate calcium-modulating cyclophilin ligand (CAML) and WRB as components of the TRC40 receptor complex and a crucial mechanism for driving ER membrane insertion of TA proteins in mammalian cells.
CAML was found to play a crucial role in the PRL/PRLR-dependent growth of breast cancer cells.
this study demonstrated that DENV manipulated the levels of CAML to subvert the apoptotic process which in turn favoured efficient virus production.
Data show that tetherin restricts particle release and does not require CAML for this effect.
CAMLG was more frequently significantly overexpressed in acute myeloid leukemia patients with CD56 immunophenoytpe
Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets cellular CAML to increase the cytosolic Ca(2+) response, which consequently protects cells from mitochondrial damage and apoptosis
CAML is an important signal transducer for the actions of Ang II in regulating the calcineurin-NFAT pathway and the interaction of CAML with ATRAP may mediate the Ang II actions in vascular physiology
The intracellular C-terminus of fibrocystin interacts with CAML, a protein with an intracellular distribution that is similar to that of PKD2.
Binding of the MUC1 CT to CAML in human epithelial cells was confirmed by reciprocal coimmunoprecipitations, confocal microscopy, protein crosslinking, and coupled transcription/translation analyses.
this study identified a novel role for B cell-specific, BAFF-dependent transmembrane activator and CAML interactor signals in atherosclerosis pathogenesis
supports T cell survival and cell division downstream of T cell activation
Deletion of calcium-modulating cyclophilin ligand causes deafness in mouse model.
Conditional deletion of CAML in CD19-Cre transgenic mice reduced follicular B cell numbers & increased rates of homeostatic proliferation. They had increased cellular turnover & normal proliferative ability.
Loss of CAMLG protein failed to undergo normal T-cell development and exhibited dramatically increased rates of apoptosis.
results implicate Tmub1 in the regulation of locomotor activity and wakefulness and suggest that Tmub1 binds to and functions together with CAMLG
These data implicate calcium-modulating cyclophilin ligand in epidermal growth factor (EGF) receptor signaling and suggest that it may play a role in receptor recycling during long-term proliferative responses to EGF.
CAML as an essential mediator of T cell survival during thymopoiesis and its loss deregulates lymphocyte specific protein tyrosine kinase p56(p56Lck) signaling.
specific role of CAML in functional expression and endocytic recycling of postsynaptic GABA(A) receptors
our data identify CAML as a novel chromosomal instability gene and suggest that CAML protein acts as a key regulator of mitotic spindle function and a modulator of SAC maintenance.
The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.
calcium modulating ligand
, calcium signal-modulating cyclophilin ligand
, calcium modulating cyclophilin ligand CAML
, calcium-modulating cyclophilin ligand
, calcium-signal modulating cyclophilin ligand
, cyclophilin B-binding protein