DRB1 Produkte
(Dopamine Receptor Binding 1 (DRB1))
Kategorien
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide\; exons 2 and 3 encode the two extracellular domains\; exon 4 encodes the transmembrane domain\; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008].
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Empfohlene DRB1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Applikation
WB
Validierungen
- (1)
Kat. Nr.
ABIN2776653
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Dog, Human, Mouse, Rat
Applikation
WB, ELISA
Validierungen
- (1)
Kat. Nr.
ABIN2462346
Menge
100 μL
Datenblatt
Datenblatt
Neueste Publikationen zu unseren DRB1 Produkten
: "The RNA-binding motif 45 (RBM45) protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients." in: Acta neuropathologica, Vol. 124, Issue 5, pp. 717-32, (2012) (PubMed).Synonyme und alternative Namen zu DRB1
dopamine receptor binding 1 (Drb1)
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