DCLK1 Produkte
(Doublecortin-Like Kinase 1 (DCLK1))
Kategorien
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010].
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Ausgewählte DCLK1 Kategorien
DCLK1 Antikörper
High quality antibodies with extensive validation data.
DCLK1 ELISA Kits
Reliable ELISA kits for a wide range of species.
DCLK1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene DCLK1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, ICC, IHC (p), IHC (fro)
Validierungen
- (6)
Kat. Nr.
ABIN7436015
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB
Validierungen
- (15)
- (3)
Kat. Nr.
ABIN391324
Menge
200 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IF
Validierungen
- (5)
Kat. Nr.
ABIN563973
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene DCLK1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN6962004
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN6955456
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6966421
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene DCLK1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Insect cells (Sf21)
Validierungen
- (2)
Kat. Nr.
ABIN5570627
Menge
5 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7122703
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1351192
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren DCLK1 Produkten
: "DCLK-1 LEVEL IN MULTIPLE SCLEROSIS PATIENTS AND ITS CORRELATION WITH CLINIC." in: Multiple sclerosis and related disorders, Vol. 43, pp. 102179, (2020) (PubMed).: "Enhancement of cytotoxic effects of gemcitabine by Dclk1 inhibition through suppression of Chk1 phosphorylation in human pancreatic cancer cells." in: Oncology reports, Vol. 38, Issue 5, pp. 3238-3244, (2018) (PubMed).
: "Catecholamines Facilitate Fuel Expenditure and Protect Against Obesity via a Novel Network of the Gut-Brain Axis in Transcription Factor Skn-1-deficient Mice." in: EBioMedicine, Vol. 8, pp. 60-71, (2017) (PubMed).
: "DCLK1 is up-regulated and associated with metastasis and prognosis in colorectal cancer." in: Journal of cancer research and clinical oncology, Vol. 142, Issue 10, pp. 2131-40, (2017) (PubMed).
: "Doublecortin-like kinase 1-positive enterocyte - a new cell type in human intestine." in: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 124, Issue 11, pp. 958-965, (2017) (PubMed).
: "Goblet Cell Ratio in Combination with Differentiation and Stem Cell Markers in Barrett Esophagus Allow Distinction of Patients with and without Esophageal Adenocarcinoma." in: Cancer prevention research (Philadelphia, Pa.), Vol. 10, Issue 1, pp. 55-66, (2017) (PubMed).
: "Data showing proliferation and differentiation of intestinal epithelial cells under targeted depletion of Notch ligands in mouse intestine." in: Data in brief, Vol. 10, pp. 551-556, (2017) (PubMed).
: "miR-613 inhibits the growth and invasiveness of human hepatocellular carcinoma via targeting DCLK1." in: Biochemical and biophysical research communications, Vol. 473, Issue 4, pp. 987-92, (2016) (PubMed).
: "Nkx2.2 is expressed in a subset of enteroendocrine cells with expanded lineage potential." in: American journal of physiology. Gastrointestinal and liver physiology, pp. ajpgi.00244.2015, (2015) (PubMed).
: "Doublecortin-like kinase 1 is elevated serologically in pancreatic ductal adenocarcinoma and widely expressed on circulating tumor cells." in: PLoS ONE, Vol. 10, Issue 2, pp. e0118933, (2015) (PubMed).
Synonyme und alternative Namen zu DCLK1
doublecortin like kinase 1 (DCLK1), doublecortin-like kinase 1a (dclk1a), serine/threonine-protein kinase DCLK1 (LOC587664), doublecortin-like kinase 2 (dclk2), serine/threonine-protein kinase DCLK1 (LOC100539645), doublecortin-like kinase 1 (Dclk1), doublecortin-like kinase 1 (DCLK1), doublecortin like kinase 1 (Dclk1), 1700113D08Rik, 2810480F11Rik, AI836758, Ania4, CL1, Click-I, CLICK1, Cpg16, DCAMKL1, dcamkl1, Dcamkl1, DCDC3A, Dcl, DCLK, Dclk, DCLK1, dclk1, MGC145348, mKIAA0369, wu:fc51f11, zgc:153709Bezeichner auf Proteinebene für DCLK1
- doublecortin-like kinase 1
- doublecortin and CaM kinase-like 1
- doublecortin and calcium/calmodulin-dependent protein kinase-like 1
- serine/threonine-protein kinase DCLK1
- doublecortin-like kinase 2
- serine/threonine-protein kinase DCLK1-like
- doublecortin domain-containing protein 3A
- doublecortin-like and CAM kinase-like 1
- CLICK-I beta
- double cortin and calcium/calmodulin-dependent protein kinase-like 1
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