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CTLA4 Proteine

(Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008].

86 Treffer

CTLA4 Spezies: Maus Wirt: Mammalian Cells Recombinant WB, SDS, ELISA, Imm
Produktnummer ABIN7893051
3.281,00 €
Zzgl. Versandkosten 20,00 € und MwSt
1 mg
Lieferung nach: Deutschland
Lieferung in 12 bis 17 Werktagen
 
CTLA4 Spezies: Human Wirt: Mammalian Cells Recombinant WB, SDS, ELISA, Imm
Produktnummer ABIN7893050
3.281,00 €
Zzgl. Versandkosten 20,00 € und MwSt
1 mg
Lieferung nach: Deutschland
Lieferung in 12 bis 17 Werktagen
 
CTLA4 Spezies: Treeshrew (Tupaia) Wirt: Mammalian Cells Recombinant WB, SDS, ELISA, Imm
Produktnummer ABIN7893054
3.281,00 €
Zzgl. Versandkosten 20,00 € und MwSt
1 mg
Lieferung nach: Deutschland
Lieferung in 12 bis 17 Werktagen
 
CTLA4 Spezies: Maus Wirt: Bacteria Recombinant
Produktnummer ABIN7819790
302,50 €
Zzgl. Versandkosten 20,00 €, Trockeneispauschale 20,00 € sowie MwSt
100 μg
Lieferung nach: Deutschland
Lieferung in 4 bis 5 Werktagen
 
CTLA4 Spezies: Treeshrew (Tupaia) Wirt: Eukaryota Recombinant
Produktnummer ABIN7820531
361,90 €
Zzgl. Versandkosten 20,00 €, Trockeneispauschale 20,00 € sowie MwSt
100 μg
Lieferung nach: Deutschland
Lieferung in 4 bis 5 Werktagen
 
CTLA4 Spezies: Treeshrew (Tupaia) Wirt: Eukaryota Recombinant
Produktnummer ABIN7820532
361,90 €
Zzgl. Versandkosten 20,00 €, Trockeneispauschale 20,00 € sowie MwSt
100 μg
Lieferung nach: Deutschland
Lieferung in 4 bis 5 Werktagen
 
  • Typ Protein
    • Protein
  • Anwendung
    • Western Blotting (WB)
    • ELISA
    • SDS-PAGE (SDS)
    • Immunogen (Imm)
    • Positive Control (PC)
    • Activity Assay (AcA)
    • Antibody Production (AbP)
    • Mass Spectrometry (MS)
    • Standard (STD)
    • Flow Cytometry (FACS)
    • Affinity Measurement (AM)
    • Functional Studies (Func)
    • Immunoassay (IA)
    • Intracellular Flow Cytometry (ICFC)
    • Protein Interaction (PI)
    • Screening Assay (ScA)
    • Antibody Drug Assay (ADA)
    • Affinity Purification (AP)
    • Antibody Array (AA)
  • Reaktivität
    • Human
    • Mouse
    • Cynomolgus
    • Rat
    • Rhesus Monkey
    • Treeshrew (Tupaia)
    • Guinea Pig
    • Rabbit
    • Dog
    • Pig
  • In Publikationen zitiert
  • Abbildungen verfügbar
  • Carrier free only
  • Wirt
    • HEK-293 Cells
    • Human Cells
    • Mammalian Cells
    • Escherichia coli (E. coli)
    • CHO Cells
    • Baculovirus infected Insect Cells
    • Yeast
    • Eukaryota
    • NS1 Cells
    • Yeast (Pichia pastoris)
    • Bacteria
    • HEK-293T Cells
    • Wheat germ
  • Bindungsspezifität
    • AA 36-161
    • AA 37-162
    • AA 37-161
    • AA 38-161
    • AA 37-160
    • partial
    • AA 36-162
    • Transcript Variant 1
    • C-Term
    • AA 1-160
    • AA 1-162
    • AA 35-153
    • AA 36-135
    • AA 36-223
    • AA 38-160
    • AA 41-192
    • AA 45-185
    • AA 52-211
  • Konjugat
    • His tag
    • Fc Tag
    • DYKDDDDK Tag
    • GST tag
    • Fc Tag,AVI tag
    • His tag,AVI tag,Biotin
    • Strep Tag
    • Unkonjugiert
    • hIgG-His-tag
    • mFc Tag
    • Biotin,His-Avi Tag
    • DYKDDDDK-His Tag
    • Fc Tag,AVI tag,Biotin
    • Fc Tag,His tag
    • His tag,ECD
    • His tag,GST tag
    • His tag,mFc Tag
    • His-Avi Tag,Biotin
    • His-DYKDDDDK-Strep II Tag
    • His-Fc tag
  • Protein-Typ
    • Recombinant
  • Format
    • Lyophilized
    • Liquid
    • Frozen
  • Biologische Aktivität
    • Biologically Active
    • Biologically Inactive
  • Hersteller
    • antibodies-online
    • ACROBiosystems
    • ProSci
    • Signalway
    • Cohesion Biosciences
    • OriGene
    • CUSABIO
    • ProteoGenix
    • BioLegend
    • FabGennix

Aktuelle Publikationen für unsere CTLA4 Proteine

Bai, Gao, Hu, Liu, Li, Dong, Huang, Zhu, Zhou, Li, Shao: "Self-Assembled Multivalent Aptamer Nanoparticles with Potential CAR-like Characteristics Could Activate T Cells and Inhibit Melanoma Growth." in: Molecular therapy oncolytics, Vol. 17, pp. 9-20, (2020) (PubMed).

Simons, Lim, Carter, Wagner, Wayham, Adler, Johnson: "Affinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCR." in: mAbs, Vol. 12, Issue 1, pp. 1803646, (2020) (PubMed).

Okada, Kajiya, Omata, Matsumoto, Sato, Kobayashi, Nakamura, Kaneko, Nakamura, Koyama, Sudo, Shin, Okamoto, Watanabe, Tachibana, Hirose, Saito, Takai, Matsumoto, Nakamura, Okabe, Miyamoto, Tanaka: "CTLA4-Ig Directly Inhibits Osteoclastogenesis by Interfering With Intracellular Calcium Oscillations in Bone Marrow Macrophages." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, (2019) (PubMed).

Ganesan, Moon, Barakat: "Revealing the atomistic details behind the binding of B7-1 to CD28 and CTLA-4: A comprehensive protein-protein modelling study." in: Biochimica et biophysica acta. General subjects, Vol. 1862, Issue 12, pp. 2764-2778, (2019) (PubMed).

Galstyan, Markman, Shatalova, Chiechi, Korman, Patil, Klymyshyn, Tourtellotte, Israel, Braubach, Ljubimov, Mashouf, Ramesh, Grodzinski, Penichet, Black, Holler, Sun, Ding, Ljubimov, Ljubimova: "Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy." in: Nature communications, Vol. 10, Issue 1, pp. 3850, (2019) (PubMed).

Gonzalez-Nieto, Castro, Bischof, Shin, Ricciardi, Bailey, Dang, Pedreño-Lopez, Magnani, Ejima, Allison, Gil, Evans, Rakasz, Lifson, Desrosiers, Martins: "Vaccine protection against rectal acquisition of SIVmac239 in rhesus macaques." in: PLoS pathogens, Vol. 15, Issue 9, pp. e1008015, (2019) (PubMed).

Ganesan, Ahmed, Okoye, Arutyunova, Babu, Turnbull, Kundu, Shields, Agopsowicz, Xu, Tabana, Srivastava, Zhang, Moon, Belovodskiy, Hena, Kandadai, Hosseini, Hitt, Walker, Smylie, West, Siraki, Lemieux et al.: "Comprehensive in vitro characterization of PD-L1 small molecule inhibitors. ..." in: Scientific reports, Vol. 9, Issue 1, pp. 12392, (2019) (PubMed).

Zhao, Lee, Lin, Gassen, Xu, Huang, Xiao, Bonorino, Lu, Bui, Hui: "PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways." in: Immunity, Vol. 51, Issue 6, pp. 1059-1073.e9, (2019) (PubMed).

Waight, Chand, Dietrich, Gombos, Horn, Gonzalez, Manrique, Swiech, Morin, Brittsan, Tanne, Akpeng, Croker, Buell, Stein, Savitsky, Wilson: "Selective FcγR Co-engagement on APCs Modulates the Activity of Therapeutic Antibodies Targeting T Cell Antigens." in: Cancer cell, Vol. 33, Issue 6, pp. 1033-1047.e5, (2019) (PubMed).

Ljungars, Svensson, Carlsson, Birgersson, Tornberg, Frendéus, Ohlin, Mattsson: "Deep Mining of Complex Antibody Phage Pools Generated by Cell Panning Enables Discovery of Rare Antibodies Binding New Targets and Epitopes." in: Frontiers in pharmacology, Vol. 10, pp. 847, (2019) (PubMed).

Aliase für CTLA4 Proteine

cytotoxic T-lymphocyte associated protein 4 (CTLA4) Proteine
cytotoxic T-lymphocyte-associated protein 4 (Ctla4) Proteine
CD Proteine
CD152 Proteine
Cd152 Proteine
CELIAC3 Proteine
CTLA-4 Proteine
Ctla-4 Proteine
CTLA4 Proteine
GRD4 Proteine
GSE Proteine
IDDM12 Proteine
Ly-56 Proteine
sCTLA4 Proteine
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