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Human Polyclonal SMARCA5 Primary Antibody für IP, WB - ABIN188620
Bryant, Colgrove, Knipe: Cellular SNF2H chromatin-remodeling factor promotes herpes simplex virus 1 immediate-early gene expression and replication. in mBio 2011
Show all 5 Pubmed References
Human Monoclonal SMARCA5 Primary Antibody für ChIP, ICC - ABIN2668296
Sims, Millhouse, Chen, Lewis, Erdjument-Bromage, Tempst, Manley, Reinberg: Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. in Molecular cell 2007
Show all 3 Pubmed References
Human Polyclonal SMARCA5 Primary Antibody für IF, WB - ABIN521924
Wang, Castro, Mulder, Markowetz: Posterior association networks and functional modules inferred from rich phenotypes of gene perturbations. in PLoS computational biology 2012
Human Polyclonal SMARCA5 Primary Antibody für IF, IP - ABIN536516
Loyola, Huang, LeRoy, Hu, Wang, Donnelly, Lane, Lee, Reinberg: Functional analysis of the subunits of the chromatin assembly factor RSF. in Molecular and cellular biology 2003
Human Polyclonal SMARCA5 Primary Antibody für ICC, IF - ABIN4354728
Polyakova, Borman, Grimley, Vamathevan, Hayes, Solari: Identification of novel interacting partners of Sirtuin6. in PLoS ONE 2012
CNBP up-regulates tbx2b and smarca5, and down-regulates wnt5b gene expression.
The tight coupling of ATP hydrolysis to DNA translocation suggests that DNA translocation is not energetically rate limiting for nucleosome repositioning by ISWI.
results demonstrate that distinctly from its role in spindle assembly, RanGTP maintains spindle microtubules in anaphase through the local activation of ISWI and that this is essential for proper chromosome segregation
Plays a critical role for ISWI chromatin remodeling complexes in neural development, including eye differentiation, in the Xenopus laevis embryo.
present the X-ray structure of Xenopus laevis ISWI SANT domain, derived from limited proteolysis of a C-terminal fragment of ISWI protein
cSMARCA5 (a circRNA derived from exons 15 and 16 of the SMARCA5 gene, hsa_circ_0001445) inhibits the growth and migration of hepatocellular carcinoma cells, making it a potential therapeutic target.
propose a model in which the acidic patch, formed by histones H2A and H2B, activates SNF2h by providing a landing pad for the NegC and AutoN auto-inhibitory domains.
circular RNA SMARCA5 as a potential novel biomarker for hepatocellular carcinoma
our data show circSMARCA5 as a promising druggable tumor suppressor in GBM and suggest that it may exert its function by tethering the RBP SRSF1.
miR-151-5p, targeting chromatin remodeler SMARCA5, may act as a useful biomarker for BRCA-related and sporadic breast cancers.
BAZ1A and BAZ1B promote recovery after DNA damage in part by recruiting SMARCA5 to damaged chromatin.
A model has been proposed in which a base excision repair complex containing damaged chromatin is recruited to specific locations in the nuclear matrix for repair, with this recruitment mediated by XRCC1-SNF2H interaction.
Overexpression of hSNF2H is associated with glioma.
The action of SNF2H at CTCF sites is functionally important as depletion of CTCF or SNF2H affects transcription of a common group of genes.
Knockdown of SMARCA5 expression in MDA-MB-231 and MDA-MB-435s cell lines.
Data show the mechanism of nucleosome sliding by the chromatin remodeling motor SNF2h protein.
CHD3.1 and ACF1-SNF2H display counteractive activities but similar histone affinities.
Data show that CCCTC-binding factor (CTCF) together with ISWI ATPase SMARCA5 and members of the Cohesin complex associate with the SPI1 protein is disrupted in acute myeloid leukemia (AML) blasts.
SMARCA5 targeting to UV-C damage depends on transcription and histone modifications and requires functional SWI2/SNF2-ATPase and SLIDE domains.
this study finds that the H4 tail promotes ATP-binding pocket closure in SNF2h.
study unveils a functional link between DNA damage-induced poly(ADP-ribosyl)ation, SMARCA5-mediated chromatin remodeling and RNF168-dependent signaling and repair of DSBs.
Data indicate that the heterochromatic H2A.X is preferentially phosphorylated presumably by the accumulating WSTF-ISWI chromatin remodeling (WICH) complex, and suggests that Tyr142p might have a specific role in heterochromatin.
Introduction of the miR-99 family of miRNAs into cells reduced the rate and overall efficiency of repair by both homologous recombination and non-homologous end joining.
Functional interaction is characterized between C/EBPbeta and SNF2H/ACF1, involving mainly suppression of C/EBPbeta transactivation activity in the presence of SNF2H and ACF1.
[review] Biochemical analysis using a mutant Vpr HIV-1 gene suggests that Vpr binds chromatin-remodeling factor SNF2h via HFRIG (i.e., amino acids 71-75).
Smarca5 plays indispensable roles during early hematopoiesis and erythropoiesis.
VGF neuropeptides promote oligodendrogenesis in vitro, whereas Snf2h cKO mice treated with full-length VGF-encoding adenoviruses removed the requirement of exercise for survival.
Snf2h is essential for the establishment of lens vesicle polarity, partitioning of prospective lens epithelial and fiber cell compartments, lens fiber cell differentiation, and lens fiber cell nuclear degradation.
Snf2h controls chromatin organization and histone H1 dynamics for the establishment of gene expression programs underlying cerebellar morphogenesis and neural maturation.
The results demonstrated a novel role of CECR2-containing complexes in spermatogenesis and showed that CECR2 interacts predominantly with SNF2H instead of SNF2L in the testis.
role for SNF2H in both repression and activation of cytokine genes.
Smarca5 is a key regulator of global chromatin structure.
Smarca5-NoRC complex has a role in heterochromatin formation and silencing of ribosomal gene transcription
Snf2h-/- embryos die during the periimplantation stage. Blastocyst outgrowth experiments indicate that loss of Snf2h results in growth arrest and cell death of both the trophectoderm and inner cell mass.
The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein.
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
, actin dependent regulator of chromatin A5
, matrix associated
, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
, imitation switch ISWI
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a5
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5
, sucrose nonfermenting protein 2 homolog
, sucrose nonfermenting-like 5