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Data suggest that SENP2 in hepatic stellate cells is involved in regulation of apoptosis in these cells and in development/reversion of liver fibrosis (here, carbon tetrachloride-induced liver fibrosis).
Expression of the SENP2 gene was suppressed by theobromine. In vivo knockdown studies showed that AR1 (zeige TCF20 Proteine) knockdown in mice attenuated the anti-adipogenic effects of theobromine in younger mice. Theobromine suppresses adipocyte differentiation and induced C/EBPbeta (zeige CEBPB Proteine) degradation by increasing its sumoylation.
SENP2 regulates Drp1 (zeige CRMP1 Proteine) sumoylation and stability critical for mitochondrial morphogenesis.SENP2 plays role in mitochondria mediated neural degeneration.
This study identified an animal model of SUDEP, which is caused by alteration of a posttranslational protein modification pathway (SUMOylation) on a unique voltage-gated potassium channel (Kv7.2/Kv7.3)
These results reveal the important role of SENP2 in the regulation of myostatin (zeige MSTN Proteine) expression and myogenesis.
SENP2 represses glycolysis and shifts glucose metabolic strategy
Data suggest that SENP2 regulates antiviral innate immunity by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation, and provide an example of cross-talk between the ubiquitin and SUMO pathways in innate immunity.
a mechanism underlying the SENP2-mediated regulation of Mdm2 (zeige MDM2 Proteine) that is critical for genome integrity in p53 (zeige TP53 Proteine)-dependent stress responses.
SENP2 de-SUMOylates PPARgamma (zeige PPARG Proteine) in myotubes, and de-SUMOylation of PPARgamma (zeige PPARG Proteine) selectively increases the expression of some PPARgamma (zeige PPARG Proteine) target genes.
Senp2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development.
Data demonstrate that downregulation of SENP2 (zeige SUMO1 Proteine) is correlated with poor prognosis in bladder cancer; SENP2 (zeige SUMO1 Proteine) inhibits TGF-beta (zeige TGFB1 Proteine) signaling and TGF-beta (zeige TGFB1 Proteine)-induced EMT (zeige ITK Proteine) of bladder cancer cell; and that its overexpression contributes to suppress bladder cancer cell invasion and metastasis through deSUMOylation of TGF-betaRI.
The variability of the SENP1 and SENP2 genes may play a role in breast cancer occurrence.
SENP2 (zeige SUMO1 Proteine) inhibits MMP13 (zeige MMP13 Proteine) expression in BC cells through de-SUMOylation of TBL1 (zeige TBL1X Proteine)/TBLR1 (zeige TBL1XR1 Proteine), which inhibits nuclear translocation of beta-catenin (zeige CTNNB1 Proteine).
miR (zeige MLXIP Proteine)-181b targets SENP2 (zeige SUMO1 Proteine) and positively regulated NF-kappaB (zeige NFKB1 Proteine) activity. NF-kappaB (zeige NFKB1 Proteine) activation by DNA damage in GBM cells confers resistance to radiation-induced death.
data identify SENP2 as an important regulator of fatty acid metabolism in skeletal muscle
SENP2 (zeige SUMO1 Proteine) regulates the transcriptional function of MEF2A (zeige MEF2A Proteine) via direct de-SUMOylation.
p90RSK-mediated SENP2-T368 phosphorylation is a master switch in disturbed-flow-induced signaling.
we show that WWOX required for stabilization of beta-catenin regulated by SENP2 in hepatocellular carcinoma cells
ESR1 repression by SENP2 is independent of its SUMO protease activity.
Many nucleoporins are mislocalized and, in some cases, reduced in level when SENP1 and SENP2 are codepleted.
SUMO1 (UBL1\; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.
SUMO-1 protease 1
, SUMO-1 protease-1
, SUMO-1/Smt3-specific isopeptidase 2
, SUMO/sentrin specific protease 2
, sentrin-specific protease 2
, sentrin/SUMO-specific protease SENP2
, SMT3-specific isopeptidase 2
, SUMO1/sentrin/SMT3 specific protease 2
, Axin-associating molecule
, SUMO/sentrin specific peptidase 2