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This study is the first to demonstrate that SNHG5 is a critical and powerful regulator that is involved in GC progression through trapping MTA2 in the cytosol.
Taken together with previous findings this suggests, that MTA (zeige DNMT1 Proteine)-RBBP is a stable complex, with a central role in the initial assembly of the human NuRD complex.
Authors identify non-canonical nuclear factor-kappaB (NF-kappaB (zeige NFKB1 Proteine)) signaling up regulated and it was directly linked with the tumor necrosis with MT2A (zeige MT2 Proteine) and pFADD genes. pFADD with MT2A (zeige MT2 Proteine) can inhibit the apoptosis and promote proliferation, of colorectal cancer cells.
These results indicated there might be a tight correlation among MTA2, Ki-67 (zeige MKI67 Proteine) and hepatocellular carcinoma prognosis
MTA2 is a crucial biomarker that is closely related with prognosis of colorectal carcinoma and also a potential molecular target for evaluating the prognosis and treatment of CRC (zeige CALR Proteine).
MTA2 overexpression enhances colony formation and tumor growth of gastric cancer cells, but not plays important role in cancer cell migration and metastasis. IL-11 (zeige IL11 Proteine) is one of the downstream effectors of MTA2 in regulating gastric cancer cells growth
MTA-2 protein may facilitate the invasive potential of non-small-cell lung cancer cells through the inhibition of the cell adhesion molecule (zeige MCAM Proteine) Ep-CAM (zeige EPCAM Proteine) and E-cadherin (zeige CDH1 Proteine), suggesting that it might be a potential therapeutic target in NSCLC.
High MTA2 protein and mRNA expression is associated with glioma.
MTA2 acts as a central hub for cytoskeletal organization and transcription and provides a link between nuclear and cytoskeletal organization.
MTA2 depletion could significantly inhibit human breast cancer cell growth and metastasis, implying that MTA2 might be involved in the progression of breast cancer.
results in MTA2 recruitment to the Stc2 promoter, concomitant with agonist-specific epigenetic modifications targeting histone H4 lysine acetylation
Mta2 expression is up-regulated during testicular Sertoli cells phagocytosis.
Sertoli cell-specific expression of MTA2 is required for transcriptional regulation of FSHR (zeige FSHR Proteine) gene during spermatogenesis.
investigation of expression/role of Mta2 in zygote/blastocyst development: Mta2 appears to be only Mta (zeige DNMT1 Proteine) expressed in zygotes; Mta2 appears to control transcription/expression of H19 (zeige NCKAP1 Proteine) and Peg3 in blastocysts; Mta2 may be involved in genetic imprinting
results suggest that GATA-3 (zeige GATA3 Proteine) interacts with MTA-2 to co-ordinately regulate Th2 cytokine and ifng (zeige IFNG Proteine) loci during T helper cell differentiation.
Assignment of the metastasis-associated gene (Mta1 (zeige MTA1 Proteine)) to mouse chromosome band 12F and the metastasis-associated gene 2 (zeige MAG Proteine) (Mta2) to mouse chromosome band 19B by fluorescence in situ hybridization
These results demonstrate the importance of FOG-2/MTA (zeige DNMT1 Proteine)/RbAp interactions for FOG-2-mediated transcriptional repression and further define the molecular interactions between the FOG (zeige APAF1 Proteine) repression motif and the NuRD complex.
Mta2/NuRD is involved in modulating IL-4 (zeige IL4 Proteine) and IFN-gamma (zeige IFNG Proteine) expression in T cell immune responses
This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.
, metastasis -associated gene 1-like 1
, metastasis associated gene family, member 2
, metastasis-associated 1-like 1
, metastasis-associated protein 2
, metastasis-associated protein MTA2
, p53 target protein in deacetylase complex
, metastais-associated gene family, member 2
, metastasis-associated gene family, member 2
, metastasis associated 1 family, member 2
, metastasis-associated protein MTA2-like
, metastasis associated 1-like 1
, metastasis associated 1-like protein