anti-IRF4 (IRF4) Antikörper

Human Interferon Regulatory Factor 4 (IRF4) Interaktionspartner

1. IRF4 is an independent prognostic factor for general MM patients.

2. Data show that the host transcript of miR (zeige MLXIP Antikörper)-223, linc-223, as a novel functional long non-coding RNA (lncRNA) and induces interferon regulatory factor 4 (IRF4) expression in acute myeloid leukemia (zeige BCL11A Antikörper).

3. Evidence for an essential role of Notch (zeige NOTCH1 Antikörper) signaling in the development of chronic lymphocytic leukemia (CLL) and establish IRF4 as a critical regulator of Notch (zeige NOTCH1 Antikörper) signaling during CLL development.

4. These results show that significantly increased levels of FOXO3 (zeige FOXO3 Antikörper), IRF4, and xIAP (zeige XIAP Antikörper) mRNA in Chinese HIV-1-infected patients.

5. Mechanistically, we found that BETi-mediated inhibition of cMYC (zeige MYC Antikörper) correlates with the upregulation of miR (zeige MLXIP Antikörper)-125b-5p and the downregulation of the cMYC (zeige MYC Antikörper)/miR (zeige MLXIP Antikörper)-125b-5p target gene IRF4, a transcriptional repressor of MICA (zeige MICA Antikörper).

6. BCL7A (zeige BCL7A Antikörper), BRWD3 (zeige BRWD3 Antikörper), and AUTS2 demonstrate significantly higher mutation frequencies among AA cases. These genes are all involved in translocations in B-cell malignancies. Moreover, we detected a significant difference in mutation frequency of TP53 (zeige TP53 Antikörper) and IRF4 with frequencies higher among CA cases. Our study provides rationale for interrogating diverse tumor cohorts to best understand tumor genomics across populations.

7. IRF4 protects arteries against neointima formation by promoting the expression of KLF4 (zeige KLF4 Antikörper) by directly binding to its promoter.

8. We propose that the Irf4 locus functions as the "reader" of TCR signal strength, and in turn, concentration-dependent activity of Irf4 "writes" T helper fate choice.

9. PU.1-induced apoptosis in myeloma cells is associated with IRF4 downregulation and subsequent IRF7 (zeige IRF7 Antikörper) upregulation.

10. GM-CSF (zeige CSF2 Antikörper) can mediate inflammation and pain by regulating IRF4-induced CCL17 (zeige CCL17 Antikörper) production

Mouse (Murine) Interferon Regulatory Factor 4 (IRF4) Interaktionspartner

1. Nur77 (zeige NR4A1 Antikörper) suppresses CD4 (zeige CD4 Antikörper)(+) T cell proliferation and uncover a suppressive role for Irf4 in TH2 polarization; halving Irf4 gene-dosage leads to increases in GATA3 (zeige GATA3 Antikörper)(+) and IL-4 (zeige IL4 Antikörper)(+) cells.

2. Muramyl dipeptide reduces fat inflammation and liver insulin (zeige INS Antikörper) resistance via NOD2 (zeige NOD2 Antikörper). NOD1 (zeige NOD1 Antikörper)-activating muropeptides exacerbate glucose intolerance. IRF4 dictates insulin (zeige INS Antikörper)-sensitizing effects of NOD2 (zeige NOD2 Antikörper), but not NOD1 (zeige NOD1 Antikörper), muropeptides.

3. Young mice had higher levels of IRF4 in the ischemic brains, suggesting that aging has a significant influence on stroke outcomes in mice, which is probably mediated by age-specific inflammatory responses.

4. IRF4 is highly induced in graft-infiltrating T cells and is required for heart transplant rejection.

5. The findings indicate that IRF4 functions as a central node in a TCR-responsive transcriptional circuit that establishes and sustains T cell exhaustion during chronic viral infection.

6. RHS6 is a critical regulatory element for allergic airway inflammation and for coordinate regulation of Th2 cytokine genes by recruiting GATA3 (zeige GATA3 Antikörper), SATB1 (zeige SATB1 Antikörper), and IRF4.

7. this study shows that epicutaneous sensitization to house dust mite allergen requires interferon regulatory factor 4-dependent dermal dendritic cells

8. Cell fate and metabolic state are linked by transcriptional regulators, such as IRF4 and FoxO1 (zeige FOXO1 Antikörper), with dual roles in lineage and metabolic choice. Instructing some cells to utilize nutrients for anabolism and differentiation while other cells catabolically self-digest and self-renew may enable growth and repair in metazoa.

9. Here the authors show that concomitant loss of Tet2 (zeige TET2 Antikörper) and Tet3 (zeige TET3 Antikörper) in mice at early B cell stage blocked the pro- to pre-B cell transition in the bone marrow, decreased Irf4 expression and impaired the germline transcription and rearrangement of the Igkappa locus.

10. IRF4 protects arteries against neointima formation by promoting the expression of KLF4 (zeige KLF4 Antikörper) by directly binding to its promoter.

Zebrafish Interferon Regulatory Factor 4 (IRF4) Interaktionspartner

1. IRF4a and IRF4b displayed a distinct tissue expression pattern, embryonic stages expression and inducible expression in vivo and in vitro, suggesting that IRF4 paralogues might play different roles in immune system.