anti-IRF4 (IRF4) Antikörper

Human Interferon Regulatory Factor 4 (IRF4) Interaktionspartner

1. Study confirmed a significant role for IRF4 rs12203592 and SLC45A2 (zeige SLC45A2 Antikörper) rs16891982 in the risk of cutaneous squamous cell carcinoma development in organ transplant recipients.

2. IRF4 is overexpressed in human non-small cell lung cancer and activates the Notch (zeige NOTCH1 Antikörper) signaling pathway.

3. IRF4 signaling is essential for activin A (zeige INHBA Antikörper) induced regulatory T cells that restrain asthmatic responses.

4. The data indicate that USP4 (zeige USP4 Antikörper) interacts with and deubiquitinates IRF4, and also stabilizes IRF4 protein and promotes IRF4 function to facilitate IL-4 (zeige IL4 Antikörper) expression in Th2 cells, which may be related to the pathological process of rheumatic heart disease.

5. IRF4 is an independent prognostic factor for general MM patients.

6. Data show that the host transcript of miR (zeige MLXIP Antikörper)-223, linc-223, as a novel functional long non-coding RNA (lncRNA) and induces interferon regulatory factor 4 (IRF4) expression in acute myeloid leukemia (zeige BCL11A Antikörper).

7. Evidence for an essential role of Notch (zeige NOTCH1 Antikörper) signaling in the development of chronic lymphocytic leukemia (CLL) and establish IRF4 as a critical regulator of Notch (zeige NOTCH1 Antikörper) signaling during CLL development.

8. These results show that significantly increased levels of FOXO3 (zeige FOXO3 Antikörper), IRF4, and xIAP (zeige XIAP Antikörper) mRNA in Chinese HIV-1-infected patients.

9. Mechanistically, we found that BETi-mediated inhibition of cMYC (zeige MYC Antikörper) correlates with the upregulation of miR (zeige MLXIP Antikörper)-125b-5p and the downregulation of the cMYC (zeige MYC Antikörper)/miR (zeige MLXIP Antikörper)-125b-5p target gene IRF4, a transcriptional repressor of MICA (zeige MICA Antikörper).

10. BCL7A (zeige BCL7A Antikörper), BRWD3 (zeige BRWD3 Antikörper), and AUTS2 demonstrate significantly higher mutation frequencies among AA cases. These genes are all involved in translocations in B-cell malignancies. Moreover, we detected a significant difference in mutation frequency of TP53 (zeige TP53 Antikörper) and IRF4 with frequencies higher among CA cases. Our study provides rationale for interrogating diverse tumor cohorts to best understand tumor genomics across populations.

Mouse (Murine) Interferon Regulatory Factor 4 (IRF4) Interaktionspartner

1. MBD2 (zeige MBD2 Antikörper) Regulates Th17 Cell Differentiation and Experimental Severe Asthma by Affecting IRF4 Expression

2. study identifies IRF4 as central regulator of TH1 (zeige HAND1 Antikörper) responses and cellular metabolism. We propose that this function of IRF4 is fundamental for the initiation and maintenance of all TH cell responses.

3. Nur77 (zeige NR4A1 Antikörper) suppresses CD4 (zeige CD4 Antikörper)(+) T cell proliferation and uncover a suppressive role for Irf4 in TH2 polarization; halving Irf4 gene-dosage leads to increases in GATA3 (zeige GATA3 Antikörper)(+) and IL-4 (zeige IL4 Antikörper)(+) cells.

4. Muramyl dipeptide reduces fat inflammation and liver insulin (zeige INS Antikörper) resistance via NOD2 (zeige NOD2 Antikörper). NOD1 (zeige NOD1 Antikörper)-activating muropeptides exacerbate glucose intolerance. IRF4 dictates insulin (zeige INS Antikörper)-sensitizing effects of NOD2 (zeige NOD2 Antikörper), but not NOD1 (zeige NOD1 Antikörper), muropeptides.

5. Young mice had higher levels of IRF4 in the ischemic brains, suggesting that aging has a significant influence on stroke outcomes in mice, which is probably mediated by age-specific inflammatory responses.

6. IRF4 is highly induced in graft-infiltrating T cells and is required for heart transplant rejection.

7. The findings indicate that IRF4 functions as a central node in a TCR-responsive transcriptional circuit that establishes and sustains T cell exhaustion during chronic viral infection.

8. RHS6 is a critical regulatory element for allergic airway inflammation and for coordinate regulation of Th2 cytokine genes by recruiting GATA3 (zeige GATA3 Antikörper), SATB1 (zeige SATB1 Antikörper), and IRF4.

9. this study shows that epicutaneous sensitization to house dust mite allergen requires interferon regulatory factor 4-dependent dermal dendritic cells

10. Cell fate and metabolic state are linked by transcriptional regulators, such as IRF4 and FoxO1 (zeige FOXO1 Antikörper), with dual roles in lineage and metabolic choice. Instructing some cells to utilize nutrients for anabolism and differentiation while other cells catabolically self-digest and self-renew may enable growth and repair in metazoa.

Zebrafish Interferon Regulatory Factor 4 (IRF4) Interaktionspartner

1. IRF4a and IRF4b displayed a distinct tissue expression pattern, embryonic stages expression and inducible expression in vivo and in vitro, suggesting that IRF4 paralogues might play different roles in immune system.