IRF4 Antikörper (AA 272-451)

Produktnummer ABIN3042469

Produktdetails anti-IRF4 Antikörper

Target: IRF4 (Interferon Regulatory Factor 4 (IRF4))

Bindungsspezifität: AA 272-451

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IRF4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Interferon regulatory factor 4(IRF4) detection. Tested with WB, IHC-P in Human.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Interferon regulatory factor 4(IRF4) detection. Tested with WB, IHC-P in Human.
Gene Name: interferon regulatory factor 4
Protein Name: Interferon regulatory factor 4

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human MUM1 recombinant protein (Position: E272-E451). Human MUM1 shares 92% amino acid (aa) sequence identity with mouse MUM1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for MUM1 is approximately 0.2 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu IRF4

Target: IRF4 (Interferon Regulatory Factor 4 (IRF4))

Andere Bezeichnung: IRF4 (IRF4 Produkte)

Synonyme: LSIRF antikoerper, MUM1 antikoerper, NF-EM5 antikoerper, AI385587 antikoerper, IRF-4 antikoerper, Spip antikoerper, IRF4 antikoerper, si:ch73-170d1.2 antikoerper, irf4 antikoerper, interferon regulatory factor 4 antikoerper, interferon regulatory factor 4a antikoerper, Interferon regulatory factor 4 antikoerper, PWWP domain-containing protein MUM1 antikoerper, IRF4 antikoerper, Irf4 antikoerper, irf4a antikoerper, irf4 antikoerper, LOC612320 antikoerper, LOC100068881 antikoerper

Hintergrund: Interferon regulatory factor 4 (IRF4), also known as MUM1, is a protein that in humans is encoded by the IRF4 gene. It is located on 6p25.3. IRF4 is a transcription factor, and it is essential for the development of T helper-2 (Th2) cells, IL17 -producing Th17 cells, and IL9 -producing Th9 cells. In melanocytic cells, the IRF4 gene may be regulated by MITF. IRF4 is a transcription factor that has been implicated in acute leukemia. This gene is strongly associated with pigmentation, sensitivity of skin to sun exposure, freckles, blue eyes, and brown hair color. What's more, IRF4 inhibition is toxic to myeloma cell lines, regardless of transforming oncogenic mechanism.

Synonyms: Interferon regulatory factor 4 antibody|IRF 4 antibody|IRF-4 antibody|Irf4 antibody|IRF4_HUMAN antibody|LSIRF antibody|Lymphocyte specific interferon regulatory factor antibody|Lymphocyte specific IRF antibody|Lymphocyte-specific interferon regulatory factor antibody|Multiple myeloma oncogene 1 antibody|MUM 1 antibody|MUM1 antibody|NF EM5 antibody|NF-EM5 antibody|NFEM5 antibody|PU.1 interaction partner antibody|Sfpi1/PU.1 interaction partner antibody|Transcriptional activator PIP antibody

Gen-ID: 3662

UniProt: Q15306

Pathways: Chromatin Binding