anti-CHD1 (CHD1) Antikörper

Human Chromodomain Helicase DNA Binding Protein 1 (CHD1) Interaktionspartner

1. CHD1 loss is associated with an increased sensitivity to PARP (zeige COL11A2 Antikörper) inhibition and anti-cancer drugs that induce DNA intercross-strand links in prostate tumors.

2. Increased CHD1L (zeige CHD1L Antikörper) protein expression was significantly associated with poor overall survival in pancreatic cancer patients.

3. CHD1 facilitates substrate handover from XPC (zeige XPC Antikörper) to the downstream TFIIH (zeige GTF2H1 Antikörper) (transcription factor IIH).

4. CHD1 is required for the induction of osteoblast-specific gene expression, extracellular-matrix mineralization and ectopic bone formation in vivo. Genome-wide occupancy analyses revealed increased CHD1 occupancy around the transcriptional start site of differentiation-activated genes.

5. examined the role of CHD1 in DNA double-strand break (DSB) repair in prostate cancer cells; findings show that CHD1 is required for the recruitment of CtIP (zeige RBBP8 Antikörper) to chromatin and subsequent end resection during DNA DSB repair; data support a role for CHD1 in opening the chromatin around the DSB to facilitate the recruitment of homologous recombination (HR) proteins

6. In PTEN-deficient prostate and breast cancers, CHD1 depletion profoundly and specifically suppressed cell proliferation, cell survival and tumorigenic potential.

7. The authors have identified an additional conserved domain C-terminal to the SANT-SLIDE domain and determined its structure by multidimensional heteronuclear NMR spectroscopy. They have termed this domain the CHD1 helical C-terminal (CHCT) domain as it is comprised of five alpha-helices arranged in a variant helical bundle topology.

8. These results indicate that CHD1 is a positive regulator of influenza virus multiplication and suggest a role for chromatin remodeling in the control of the influenza virus life cycle.

9. These data link the assembly of methylated KDM1A (zeige KDM1A Antikörper) and CHD1 with AR-dependent transcription and genomic translocations, thereby providing mechanistic insight into the formation of TMPRSS2 (zeige TMPRSS2 Antikörper)-ERG (zeige ERG Antikörper) gene fusions during prostate-tumor evolution.

10. We have identified CHD1 as the RUNX1 (zeige RUNX1 Antikörper) fusion partner in acute myeloid leukemia (zeige BCL11A Antikörper) with t(5;21)(q21;q22).

Silk Worm Chromodomain Helicase DNA Binding Protein 1 (CHD1) Interaktionspartner

1. CHD1 is a critical factor for proper development of the follicular epithelium in terms of whole-cell chromatin arrangement.

Mouse (Murine) Chromodomain Helicase DNA Binding Protein 1 (CHD1) Interaktionspartner

1. CHD1 loss is associated with an increased sensitivity to PARP (zeige PARP1 Antikörper) inhibition and anti-cancer drugs that induce DNA intercross-strand links in prostate tumors.

2. These results underscore the importance of Chd1 for the regulation of pluripotency in ESCs (zeige NR2E3 Antikörper) and provide evidence for a hitherto unrecognized critical role of the phosphorylated N-terminal SRR (zeige SRR Antikörper) for full functionality of Chd1.

3. find that Chd1 evicts nucleosomes downstream of the promoter in order to overcome the nucleosomal barrier and enable PolII (zeige Pol II Antikörper) promoter escape, thus providing mechanistic insight into the role of Chd1 in transcription and pluripotency

4. These findings indicate that CHD1 plays important roles in mouse early embryogenesis via activation of Hmgpi at zygotic gene activation.

5. Chd1-driven elevation in transcriptional output is essential for the developmental transition from endothelium to definitive hematopoiesis in the mouse embryo.

6. Chd1 promotes a globally elevated transcriptional output required to sustain the distinctly rapid growth of the mouse epiblast.

7. CHD1 and Mediator are recruited to an inducible gene, and genome-wide binding of the two proteins correlates well with active gene transcription in mouse ES cells

8. results indicate that Chd1 is essential for open chromatin and pluripotency of embryonic stem cells, and for somatic cell reprogramming to the pluripotent state

Fruit Fly (Drosophila melanogaster) Chromodomain Helicase DNA Binding Protein 1 (CHD1) Interaktionspartner

1. An effect of Chd1 null mutation can be increased by deficiency of one of the genes, encoding variant histone H3.3, His 3.3 B, suggesting that the role of CHD1 in the control of male X chromosome organization can be mediated by CHD1 activity in H3.3 histone deposition and exchange.

2. The Drosophila melanogaster CHD1 chromatin remodeling factor (zeige ASH1L Antikörper) modulates global chromosome structure and counteracts HP1a (zeige CBX5 Antikörper) and H3K9me2.

3. Intestinal resistance against infection by P. aeruginosa is linked to maintaining proper balance of gut (zeige GUSB Antikörper)-microbe interactions and the chromatin remodeler CHD1 is involved in regulating this aspect.

4. our results emphasize a role for Chd1 in histone replacement in both budding yeast and Drosophila melanogaster, and surprisingly they show that the major effects of Chd1 on turnover occur at the 3' ends of genes.

5. results suggest a role for CHD1 in the assembly of active chromatin and a function of ACF (zeige A1CF Antikörper) in the assembly of repressive chromatin

6. findings establish CHD1 as a major factor in replacement histone metabolism in the nucleus and reveal a critical role for CHD1 in the earliest developmental instances of genome-scale, replication-independent nucleosome assembly.

7. These results clarify the roles of chromatin remodelers in transcription and provide novel insights into CHD1 function.