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anti-Human SCARB1 Antikörper:
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Chinese Hamster Polyclonal SCARB1 Primary Antibody für FACS, ICC - ABIN152882
Brodeur, Luangrath, Bourret, Falstrault, Brissette: Physiological importance of SR-BI in the in vivo metabolism of human HDL and LDL in male and female mice. in Journal of lipid research 2005
Show all 155 Pubmed References
Chinese Hamster Polyclonal SCARB1 Primary Antibody für BP, FACS - ABIN152880
Huang, Mazzone: ApoE-dependent sterol efflux from macrophages is modulated by scavenger receptor class B type I expression. in Journal of lipid research 2002
Show all 82 Pubmed References
Human Polyclonal SCARB1 Primary Antibody für BP, FACS - ABIN152890
Wüstner, Mondal, Huang, Maxfield: Different transport routes for high density lipoprotein and its associated free sterol in polarized hepatic cells. in Journal of lipid research 2004
Show all 29 Pubmed References
Hamster Polyclonal SCARB1 Primary Antibody für FACS, ICC - ABIN152899
Bocharov, Baranova, Vishnyakova, Remaley, Csako, Thomas, Patterson, Eggerman et al.: Targeting of scavenger receptor class B type I by synthetic amphipathic alpha-helical-containing peptides blocks lipopolysaccharide (LPS) uptake and LPS-induced pro-inflammatory cytokine responses in ... in The Journal of biological chemistry 2004
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Human Polyclonal SCARB1 Primary Antibody für FACS, ICC - ABIN152901
Harder, Meng, Rippstein, McBride, McPherson: SR-BI undergoes cholesterol-stimulated transcytosis to the bile canaliculus in polarized WIF-B cells. in The Journal of biological chemistry 2007
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Human Polyclonal SCARB1 Primary Antibody für WB - ABIN1881777
Kolmakova, Wang, Brogan, Chaffin, Rodriguez: Deficiency of scavenger receptor class B type I negatively affects progesterone secretion in human granulosa cells. in Endocrinology 2010
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Human Monoclonal SCARB1 Primary Antibody für IF, WB - ABIN968230
Acton, Rigotti, Landschulz, Xu, Hobbs, Krieger: Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. in Science (New York, N.Y.) 1996
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Human Monoclonal SCARB1 Primary Antibody für IF, WB - ABIN968231
Calvo, Vega: Identification, primary structure, and distribution of CLA-1, a novel member of the CD36/LIMPII gene family. in The Journal of biological chemistry 1993
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Chinese Hamster Polyclonal SCARB1 Primary Antibody für IHC (fro), IHC (p) - ABIN268843
Hullinger, Panek, Xu, Karathanasis: p21-activated kinase-1 (PAK1) inhibition of the human scavenger receptor class B, type I promoter in macrophages is independent of PAK1 kinase activity, but requires the GTPase-binding domain. in The Journal of biological chemistry 2001
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Chicken Polyclonal SCARB1 Primary Antibody für FACS, IF (p) - ABIN738936
Gabriel, Becher-Deichsel, Hlavaty, Mair, Walter: The physiological expression of scavenger receptor SR-B1 in canine endometrial and placental epithelial cells and its potential involvement in pathogenesis of pyometra. in Theriogenology 2016
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Liposomes modified with both apolipoproteins A-I and E were internalized in HepG2 cells in FBS (zeige FBXO8 Antikörper)-depleted culture medium at the same levels as unmodified liposomes in FBS (zeige FBXO8 Antikörper)-containing culture medium, which indicates that apolipoproteins A-I and E were the major serum components involved in liposomal binding to SR-B1 or LDLR (zeige LDLR Antikörper) (or both).
Here we show that inhibition of SR-B1 reduced cell survival, migration and invasion, and cholesterol content in NB cell lines. Additionally analysis of SR-B1 levels in NB patient biopsies using the R2: Genomics Analysis and Visualization Platform showed that high SR-B1 expression correlated with decreased overall and event-free survival.
the cigarette smoke (CS)-induced loss of SRB1 induced an alteration of sebocytes lipid content, also demonstrated by cholesterol quantification in SRB1 siRNA experiments. In conclusion, exposure to CS, induced SRB1 post-translational modifications in sebocytes and this might affect sebocytes/skin functionality
Low SRB1 expression is associated with non-alcoholic steatohepatitis but is unchanged in hepatocellular carcinoma.
SCARB1 rs5888 and environmental oxidative stress have a prominent role in age-related macular degeneration(ARMD) susceptibility, early ARMD progression to advanced stage disease and even in the outcome of the disease-an area of macular lesion.
SCARB1 gene variants are associated with a new lipid phenotype, characterized by high levels of both HDL (zeige HSD11B1 Antikörper) cholesterol and Lp(a (zeige APOA Antikörper)). SCARB1 exonic variants often result in diminished function of translated SR-B1 via reduced binding/intracellular transport of Lp(a (zeige APOA Antikörper)).
Data suggest that activation of SR-BI by APOAI down-regulates sphingosine 1-phosphate/S1PR2 (zeige S1PR2 Antikörper)-mediated inflammation in vascular endothelial cells by activating the PI3K (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper) signaling pathway; oxidized-LDL does the opposite. (APOA1 (zeige APOA1 Antikörper) = apolipoprotein A-I (zeige APOA1 Antikörper); SR-BI/SCARB1 = scavenger receptor class B type I; S1PR2 (zeige S1PR2 Antikörper) = sphingosine 1-phosphate receptor 2 (zeige S1PR2 Antikörper); PI3K (zeige PIK3CA Antikörper) = phosphatidylinositol 3-kinase; Akt (zeige AKT1 Antikörper) = proto-oncogene c-akt (zeige AKT1 Antikörper))
Sustained virologic response was significantly associated with SCARB1 rs10846744 in chronic hepatitis C patients, treated with pegylated interferon-alpha (zeige IFNA Antikörper) and ribavirin.
Model recombinant HDL (zeige HSD11B1 Antikörper) (rHDL) particles formed in vitro with S1P (zeige MBTPS1 Antikörper) incorporated into the particle initiated the internalization of S1PR1 (zeige S1PR1 Antikörper), whereas rHDL without supplemented S1P (zeige MBTPS1 Antikörper) did not, suggesting that S1P (zeige MBTPS1 Antikörper) transported in HDL (zeige HSD11B1 Antikörper) can selectively activate S1PR1 (zeige S1PR1 Antikörper).
Data implicate that scavenger receptor class B member 1 (SR-B1) as a target in chronic lymphocytic leukemia (CLL) and high-density lipoproteins nanoparticles (HDL (zeige HSD11B1 Antikörper) NPs (zeige NPS Antikörper)) as targeted monotherapy for CLL.
To investigate the pharmacokinetics (PKs) and pharmacodynamics (PDs (zeige SLC26A4 Antikörper)) for ION-353382, an antisense oligonucleotide (ASO) targeting scavenger receptor class B type I (SRB1) mRNA, using alpha-2-macroglobulin (A2M (zeige A2M Antikörper)), murinoglobulin double-knockout (DKO), and wild-type mice
Rutaecarpine was identified to be a candidate that protected ApoE (zeige APOE Antikörper)(-/-) mice from developing atherosclerosis through preferentially promoting activities of ABCA1 (zeige ABCA1 Antikörper) and SR-BI within RCT (zeige FOXE3 Antikörper).
SR-B1 is a silica receptor associated with canonical inflammasome activation.
Our results suggest that LPA-enhanced foam cell formation is mediated by LPA1 (zeige LPAR1 Antikörper)/3 -AKT (zeige AKT1 Antikörper) activation and subsequent SRBI expression.
Results show the first high-resolution structure of the C-terminal transmembrane domain of SR-BI. This region of SR-BI harbors a leucine zipper dimerization motif, which when mutated impairs the ability of the receptor to bind HDL (zeige HSD11B1 Antikörper) and mediate cholesterol delivery.
Carboxy-terminal deletion of SR-BI reduced receptor levels in liver and steroidogenic tissues (adrenal cortex, ovary, testicular Leydig cells) and induced hypercholesterolemia.
Loss of ScarB1 is associated with Coronary Atherosclerosis and Ischemic Heart Disease in Low-density Lipoprotein Receptor (zeige LDLR Antikörper) Knockout Mice when fed the modified western-type diet.
We showed here that SR-BI deficiency led to increased atherogenesis with features of advanced fibroatheroma and expansive arterial remodeling in LDL-R KO mice fed an atherogenic diet.
The seven intron CGIs are methylated differentially in Y1 cells, mouse Leydig tumor cells, ovarian granulosa cells, and mouse liver hepa 1-6 cells; experiments raised the possibility that DNA methylation (zeige HELLS Antikörper) participates in hormonal regulation of SR-BI expression in a tissue-specific manner.
Luteinization causes upregulation of SR-BI expression, its posttranslational maturation by glycosylation, and insertion into luteal cell membranes.
Aortic endothelial cells transcytose high-density lipoproteins by mechanisms that involve either SR-BI or ABCG1 (zeige ABCG1 Antikörper) but not ABCA1 (zeige ABCA1 Antikörper).
The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.
scavenger receptor class B member 1
, scavenger receptor class B, member 1
, scavenger receptor class B type I
, high density lipoprotein receptor SR-BI
, CD36 and LIMPII analogous 1
, CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1
, scavenger receptor class B type III
, HDL QTL 1
, scavenger receptor class B1
, CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1 (scavanger receptor class B type 1)
, scavanger receptor class B type 1
, CD36 antigen (collagen type I receptor, thrombospondin receptor-like 1)