SCARB1 Antikörper (N-Term)

Produktnummer ABIN1881777

Produktdetails anti-SCARB1 Antikörper

Target: SCARB1 (Scavenger Receptor Class B, Member 1 (SCARB1))

Bindungsspezifität: AA 72-101, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SCARB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: Pig

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SCARB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 72-101 amino acids from the N-terminal region of human SCARB1.

Klon: RB41754

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-SCARB1 Antikörper (ABIN1881777)

Kolmakova, Wang, Brogan, Chaffin, Rodriguez: "Deficiency of scavenger receptor class B type I negatively affects progesterone secretion in human granulosa cells." in: Endocrinology, Vol. 151, Issue 11, pp. 5519-27, (2010) (PubMed).

Teslovich, Musunuru, Smith, Edmondson, Stylianou, Koseki, Pirruccello, Ripatti, Chasman, Willer, Johansen, Fouchier, Isaacs, Peloso, Barbalic, Ricketts, Bis, Aulchenko, Thorleifsson, Feitosa et al.: "Biological, clinical and population relevance of 95 loci for blood lipids. ..." in: Nature, Vol. 466, Issue 7307, pp. 707-13, (2010) (PubMed).

Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, (2010) (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

Ruaño, Thompson, Kane, Pullinger, Windemuth, Seip, Kocherla, Holford, Wu: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, (2010) (PubMed).

Details zu SCARB1

Target: SCARB1 (Scavenger Receptor Class B, Member 1 (SCARB1))

Andere Bezeichnung: SCARB1 (SCARB1 Produkte)

Synonyme: cb1015 antikoerper, SCARB1 antikoerper, Scarb1 antikoerper, CD36L1 antikoerper, CLA-1 antikoerper, CLA1 antikoerper, HDLQTL6 antikoerper, SR-BI antikoerper, SRB1 antikoerper, AI120173 antikoerper, CD36 antikoerper, Cd36l1 antikoerper, Cla-1 antikoerper, Cla1 antikoerper, D5Ertd460e antikoerper, Hdlq1 antikoerper, Hlb398 antikoerper, SR-B1 antikoerper, SRBI antikoerper, Srb1 antikoerper, mSR-BI antikoerper, scavenger receptor class B, member 1 antikoerper, scavenger receptor class B member 1 antikoerper, scarb1 antikoerper, SCARB1 antikoerper, Scarb1 antikoerper, CpipJ_CPIJ014332 antikoerper, CpipJ_CPIJ019101 antikoerper

Hintergrund: Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester (By similarity).

Molekulargewicht: 60878

NCBI Accession: NP_005496

UniProt: Q8WTV0

Pathways: Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Lipid Metabolism, SARS-CoV-2 Protein Interaktom