Metadherin Proteine (MTDH)

Mouse (Murine) Metadherin (MTDH) Interaktionspartner

1. Up regulation of AEG protein plays a role in the pathogenesis of NAFLD.

2. miR (zeige MLXIP Proteine)-26a is capable of suppressing the proliferation and migration of ESCC cells via negative regulation of metadherin

3. Mtdh is a potent modulator of podocyte apoptosis.

4. AEG-1 thus might play a role in NTIS associated with HCC (zeige FAM126A Proteine) and other cancers.

5. When fed a high fat and cholesterol diet (HFD), WT mice rapidly gained weight, whereas AEG-1 KO mice did not gain weight at all.

6. MTDH has a critical role in male fertility and the DNA repair mechanisms required for normal spermatogenesis

7. Data provide evidence that MTDH has a functional role in the progression and metastatic spread of ovarian cancer.

8. RNA-sequencing analysis identified a unique gene signature in livers of Alb (zeige ALB Proteine)/AEG-1/c-Myc (zeige MYC Proteine) mice that was not observed when either AEG-1 or c-Myc (zeige MYC Proteine) was overexpressed

9. Findings establish a pivotal role for MTDH in prostate cancer progression and metastasis.

10. IL-1beta (zeige IL1B Proteine)- or TNF-alpha (zeige TNF Proteine)-induced AEG-1 interaction with NF-kappaB (zeige NFKB1 Proteine) p65 (zeige NFkBP65 Proteine) subunit.

Human Metadherin (MTDH) Interaktionspartner

1. Knockdown of MTDH gene effectively inhibits the proliferation and metastasis of SGC7901 cells.

2. oncogenic role of AEG-1 in melanoma

3. Findings clearly demonstrate that miR (zeige MLXIP Proteine)-320a suppresses breast cancer metastasis by directly inhibiting MTDH expression. The present study provides a new insight into anti-oncogenic roles of miR (zeige MLXIP Proteine)-320a.

4. Results show that miR (zeige MLXIP Proteine)-342-3p inhibits the proliferation, migration, and invasion of osteosarcoma cells through targeting AEG-1.

5. AEG-1 knockdown inhibits migration and invasion, as well as radiation-enhanced invasion both in vitro and in vivo I colonic cancer cells.

6. Study shows that expression of AEG-1 was significantly higher in macrophages and associated with elevated expression levels of MMP-9 (zeige MMP9 Proteine) in hypopharyngeal cancer. These results demonstrate that macrophage AEG-1 promotes tumor invasion through up-regulation of MMP-9 (zeige MMP9 Proteine) in both macrophages and cancer cells.

7. Gene expression data and in silico database analysis showed that the metadherin gene (MTDH) was a direct target of both miR (zeige MLXIP Proteine)-145-5p and miR (zeige MLXIP Proteine)-145-3p regulation and high expression of MTDH predicted poorer survival of lung squamous cell carcinoma patients.

8. Results demonstrated that AEG-1 significantly enhanced invasion capabilities of OVCAR3 ovarian cancer cells and suggested that HIF-1alpha (zeige HIF1A Proteine) binds to AEG-1 promoter to upregulate its expression, which was correlated with metastasis in ovarian cancer.

9. The present work aims to investigate the relationship between the expression of AEG-1(astrocyte elevated gene-1), b-FGF(basic-fibroblast growth factor (zeige FGF2 Proteine)), beta-catenin (zeige CTNNB1 Proteine), Ki-67 (zeige MKI67 Proteine), TNF-alpha (tumor necrosis factor (zeige TNF Proteine)-alfa) other prognostic parameters in DC (Ductal Carcinomas) and ductal intraepithelial neoplasm. We found a relationship between these factors.

10. Expression of AEG-1 was strongly associated with stem cell markers CD133 and SOX2 (zeige SOX2 Proteine). AEG-1 facilitated beta-catenin (zeige CTNNB1 Proteine) translocation into the nucleus by forming a complex with LEF1 (zeige LEF1 Proteine) and beta-catenin (zeige CTNNB1 Proteine), subsequently activating Wnt (zeige WNT2 Proteine) signaling downstream genes.