Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Human MTDH Protein expressed in HEK-293 Cells - ABIN2712327
Çelik, Sajwan, Selvanathan, Marsh, Pai, Kont, Han, Minas, Rahim, Erkizan, Toretsky, Üren: Ezrin Binds to DEAD-Box RNA Helicase DDX3 and Regulates Its Function and Protein Level. in Molecular and cellular biology 2015
Up regulation of AEG protein plays a role in the pathogenesis of NAFLD.
miR (zeige MLXIP Proteine)-26a is capable of suppressing the proliferation and migration of ESCC cells via negative regulation of metadherin
Mtdh is a potent modulator of podocyte apoptosis.
AEG-1 thus might play a role in NTIS associated with HCC (zeige FAM126A Proteine) and other cancers.
When fed a high fat and cholesterol diet (HFD), WT mice rapidly gained weight, whereas AEG-1 KO mice did not gain weight at all.
MTDH has a critical role in male fertility and the DNA repair mechanisms required for normal spermatogenesis
Data provide evidence that MTDH has a functional role in the progression and metastatic spread of ovarian cancer.
RNA-sequencing analysis identified a unique gene signature in livers of Alb (zeige ALB Proteine)/AEG-1/c-Myc (zeige MYC Proteine) mice that was not observed when either AEG-1 or c-Myc (zeige MYC Proteine) was overexpressed
Findings establish a pivotal role for MTDH in prostate cancer progression and metastasis.
IL-1beta (zeige IL1B Proteine)- or TNF-alpha (zeige TNF Proteine)-induced AEG-1 interaction with NF-kappaB (zeige NFKB1 Proteine) p65 (zeige NFkBP65 Proteine) subunit.
miR (zeige MLXIP Proteine)-197 expression was downregulated in gastric cancer and aberrantly expressed miR (zeige MLXIP Proteine)-197 may partially influence gastric cancer cell proliferation and invasion by directly targeting MTDH.
The findings suggest that AEG-1 promotes gastric cancer metastasis through upregulation of eIF4E (zeige EIF4E Proteine)-mediated MMP-9 (zeige MMP9 Proteine) and Twist.
our results indicated that miR (zeige MLXIP Proteine)-1297 functioned as a tumor suppressor gene in regulating the EMT (zeige ITK Proteine) and metastasis of cervical cancer (CC)via targeting of AEG-1, and may represent a novel potential therapeutic target and prognostic marker for CC
Data suggest that MIR1271 is down-regulated in colorectal cancer tissues and cell lines; MIR1271 appears to negatively regulate MTDH expression in colorectal cancer cells; MIR1271 also activates Wnt (zeige WNT2 Proteine) signaling and suppresses proliferation and invasion/movement of colorectal cancer cells. (MIR1271 = microRNA-1271; MTDH = metadherin)
we have identified a novel mechanism for DIM- and ring-DIM-induced protective autophagy, via induction of AEG-1 and subsequent activation of AMPK (zeige PRKAA1 Proteine). Our findings could facilitate the development of novel drug therapies for prostate cancer that include selective autophagy inhibitors as adjuvants.
miR (zeige MLXIP Proteine)-384 and AEG-1 may serve as potential targets for the diagnosis and treatment of non-small-cell lung cancer.
Study confirmed that hypoxia increased MTDH expression via HIF-1alpha (zeige HIF1A Proteine) expression. Knockdown of MTDH expression in head and neck squamous cell carcinoma (HNSCC) cell lines interrupted hypoxiainduced metastasis and glycolysis. Furthermore, reduced MTDH expression decreased HIF-1alpha (zeige HIF1A Proteine) expression. These results indicated the presence of a positive feedback loop between MTDH and HIF-1alpha (zeige HIF1A Proteine) in HNSCC.
Through the analysis of the Cancer Genome Atlas (TCGA) datasets for estrogen receptor (ER (zeige ESR1 Proteine))-positive endometrial and breast cancers, this study found that over 25% of all gene expression correlated with MTDH.
The results indicated that high MTDH expression is significantly correlated with higher mortality in breast, ovarian and cervical cancer. (Meta-analysis)
In-depth review of the role of AEG-1 in a diverse spectrum of diseases, from cancer to HIV-1 and aging, highlighting mechanistic processes that synergize with known AEG-1 functions and promoting the notion that AEG-1 occupies a unique niche in inflammation, mitochondrial, ER and nucleolar stress, culminating in excitotoxicity and other neurodegenerative outcomes.
human and mouse homologs are overexpressed in breast cancer tissue, bind to lung vasculature, and may play a role in promoting metastasis
, protein LYRIC
, protein LYRIC-like
, lysine-rich CEACAM1 co-isolated protein
, metastasis adhesion protein
, astrocyte elevated gene-1 protein