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Human MTDH Protein expressed in HEK-293 Cells - ABIN2712327
Çelik, Sajwan, Selvanathan, Marsh, Pai, Kont, Han, Minas, Rahim, Erkizan, Toretsky, Üren: Ezrin Binds to DEAD-Box RNA Helicase DDX3 and Regulates Its Function and Protein Level. in Molecular and cellular biology 2015
Up regulation of AEG protein plays a role in the pathogenesis of NAFLD.
miR (zeige MLXIP Proteine)-26a is capable of suppressing the proliferation and migration of ESCC cells via negative regulation of metadherin
Mtdh is a potent modulator of podocyte apoptosis.
AEG-1 thus might play a role in NTIS associated with HCC (zeige FAM126A Proteine) and other cancers.
When fed a high fat and cholesterol diet (HFD), WT mice rapidly gained weight, whereas AEG-1 KO mice did not gain weight at all.
MTDH has a critical role in male fertility and the DNA repair mechanisms required for normal spermatogenesis
Data provide evidence that MTDH has a functional role in the progression and metastatic spread of ovarian cancer.
RNA-sequencing analysis identified a unique gene signature in livers of Alb (zeige ALB Proteine)/AEG-1/c-Myc (zeige MYC Proteine) mice that was not observed when either AEG-1 or c-Myc (zeige MYC Proteine) was overexpressed
Findings establish a pivotal role for MTDH in prostate cancer progression and metastasis.
IL-1beta (zeige IL1B Proteine)- or TNF-alpha (zeige TNF Proteine)-induced AEG-1 interaction with NF-kappaB (zeige NFKB1 Proteine) p65 (zeige NFkBP65 Proteine) subunit.
Knockdown of MTDH gene effectively inhibits the proliferation and metastasis of SGC7901 cells.
oncogenic role of AEG-1 in melanoma
Findings clearly demonstrate that miR (zeige MLXIP Proteine)-320a suppresses breast cancer metastasis by directly inhibiting MTDH expression. The present study provides a new insight into anti-oncogenic roles of miR (zeige MLXIP Proteine)-320a.
Results show that miR (zeige MLXIP Proteine)-342-3p inhibits the proliferation, migration, and invasion of osteosarcoma cells through targeting AEG-1.
AEG-1 knockdown inhibits migration and invasion, as well as radiation-enhanced invasion both in vitro and in vivo I colonic cancer cells.
Study shows that expression of AEG-1 was significantly higher in macrophages and associated with elevated expression levels of MMP-9 (zeige MMP9 Proteine) in hypopharyngeal cancer. These results demonstrate that macrophage AEG-1 promotes tumor invasion through up-regulation of MMP-9 (zeige MMP9 Proteine) in both macrophages and cancer cells.
Gene expression data and in silico database analysis showed that the metadherin gene (MTDH) was a direct target of both miR (zeige MLXIP Proteine)-145-5p and miR (zeige MLXIP Proteine)-145-3p regulation and high expression of MTDH predicted poorer survival of lung squamous cell carcinoma patients.
Results demonstrated that AEG-1 significantly enhanced invasion capabilities of OVCAR3 ovarian cancer cells and suggested that HIF-1alpha (zeige HIF1A Proteine) binds to AEG-1 promoter to upregulate its expression, which was correlated with metastasis in ovarian cancer.
The present work aims to investigate the relationship between the expression of AEG-1(astrocyte elevated gene-1), b-FGF(basic-fibroblast growth factor (zeige FGF2 Proteine)), beta-catenin (zeige CTNNB1 Proteine), Ki-67 (zeige MKI67 Proteine), TNF-alpha (tumor necrosis factor (zeige TNF Proteine)-alfa) other prognostic parameters in DC (Ductal Carcinomas) and ductal intraepithelial neoplasm. We found a relationship between these factors.
Expression of AEG-1 was strongly associated with stem cell markers CD133 and SOX2 (zeige SOX2 Proteine). AEG-1 facilitated beta-catenin (zeige CTNNB1 Proteine) translocation into the nucleus by forming a complex with LEF1 (zeige LEF1 Proteine) and beta-catenin (zeige CTNNB1 Proteine), subsequently activating Wnt (zeige WNT2 Proteine) signaling downstream genes.
human and mouse homologs are overexpressed in breast cancer tissue, bind to lung vasculature, and may play a role in promoting metastasis
, protein LYRIC
, protein LYRIC-like
, lysine-rich CEACAM1 co-isolated protein
, metastasis adhesion protein
, astrocyte elevated gene-1 protein