Metadherin Proteine (MTDH)

Mouse (Murine) Metadherin (MTDH) Interaktionspartner

1. Data show MTDH mRNA expression upregulated in cervical cancer tissues and inversely correlated with miR-433 expression. Its knockdown showed similar tumor-suppressive roles as miR-433 overexpression in regards to cervical cancer cell proliferation, invasion and apoptosis. MTDH overexpression markedly reversed the effects of miR-433 overexpression in regards to proliferation, invasion and of cervical cancer cells.

2. Up regulation of AEG protein plays a role in the pathogenesis of NAFLD.

3. miR-26a is capable of suppressing the proliferation and migration of ESCC cells via negative regulation of metadherin

4. Mtdh is a potent modulator of podocyte apoptosis.

5. AEG-1 thus might play a role in NTIS associated with HCC and other cancers.

6. When fed a high fat and cholesterol diet (HFD), WT mice rapidly gained weight, whereas AEG-1 KO mice did not gain weight at all.

7. MTDH has a critical role in male fertility and the DNA repair mechanisms required for normal spermatogenesis

8. Data provide evidence that MTDH has a functional role in the progression and metastatic spread of ovarian cancer.

9. RNA-sequencing analysis identified a unique gene signature in livers of Alb/AEG-1/c-Myc mice that was not observed when either AEG-1 or c-Myc was overexpressed

10. Findings establish a pivotal role for MTDH in prostate cancer progression and metastasis.

11. IL-1beta- or TNF-alpha-induced AEG-1 interaction with NF-kappaB p65 subunit.

12. MTDH supports the survival of mammary epithelial cells under oncogenic/stress conditions by interacting with and stabilizing SND1.

13. oncogene metadherin modulates the apoptotic pathway based on the tumor necrosis factor superfamily member TRAIL (Tumor Necrosis Factor-related Apoptosis-inducing Ligand) in breast cancer

14. The present findings report the novel role of AEG-1 in mediating reactive astrogliosis and in regulating astrocyte responses to injury.

15. miR-375 targets AEG-1 in HCC and suppresses liver cancer cell growth in vitro and in vivo

16. MTDH may promote hepatocellular carcinoma metastasis through the induction of epithelial-mesenchymal transition process

17. AEG-1 may contribute to cell proliferation during the early development. AEG-1 expression was detected in the developing brain, the neural tube, skin and liver, which correlates with organ sites in which AEG-1 has been implicated in cancer development.

18. although AEG-1 does not affect MDR1 gene transcription, it facilitates association of MDR1 mRNA to polysomes, resulting in increased translation

19. Lyric is localized to the membrane of the endoplasmic reticulum, nuclear envelope, and the nucleolus.

20. overexpression of metadherin is associated with metastatic breast cancer

Human Metadherin (MTDH) Interaktionspartner

1. MTDH showed a higher copy number ratio in invasive carcinoma of the breast in males compared to adjacent and pure ductal carcinoma in situ and may therefore play a role in male breast carcinogenesis.

2. miR-1297 inhibits the growth and metastasis of pancreatic adenocarcinoma by downregulating MTDH expression

3. miRNA98 expression was downregulated in patients with hypopharyngeal carcinoma. Downregulation of miRNA98 promoted cell growth, migration, and decreased the apoptotic rate of hypopharyngeal carcinoma cells. MTDH is a direct target of miRNA98 and overexpression of miRNA98 induced the protein expression of PTEN and suppressed that of PI3K and pAkt.

4. overexpressing AEG-1 aggravated lipopolysaccharide-triggered injury and activation of NLRP3 inflammasome.

5. High AEG-1 expression is associated with renal cell carcinoma.

6. Our data presents evidence that AEG-1, LC3-II, Beclin-1, and HIF-1alpha are significantly up-regulated in T-NHL tissues, and hypoxia triggers AEG-1, LC3-II and Beclin-1 expression in T-NHL cells.

7. The AEG-1/Notch1 signaling axis plays a vital role in ccRCC cell growth and metastasis.

8. Study found that miR466 was obviously decreased in hepatocellular carcinoma (HCC) tissues and cell lines. In addition, metadherin (MTDH) was identified as a direct target of miR466 in HCC cells. Furthermore, MTDH was upregulated in HCC tissues, which was inversely correlated with the miR466 level.

9. rs1835740 MTDH gene is a potential risk factor for cluster headache in Sweden, MTDH might be involved in neurovascular headaches

10. These findings indicate that microRNA-30a may act as a tumor suppressor in colorectal cancer and that microRNA-30a represses cell migration and invasion by decreasing metadherin

11. High MTDH expression is associated with colorectal cancer.

12. miR-655 directly targets and downregulates MTDH mRNA expression in oral squamous cell carcinoma cells.

13. Metadherin (MTDH) was validated as a direct target gene of miR874 in retinoblastoma cells.

14. AEG-1 as a target gene of miR-216b action.

15. AEG-1 participates in the effects of miR-625-3p on thyroid cancer cells.

16. Findings provide the first evidence that the aberrant expression of miR-136 may be implicated into carcinogenesis and cancer progression of OS. Functionally, miR-136 may inhibit the proliferation, migration and invasion of OS cells via negatively regulating its target gene MTDH.

17. AEG-1 was found to be significantly associated with hypoxia in ovarian cancer by regulating the HIF-1alpha/NF-kappaB/VEGF pathway.

18. Reduction of TUG1 level suppressed cell growth and metastasis by regulating AEG1 expression mediated by targeting miR-129-5p.

19. miR96 may impede the epithelial to mesenchymal transition process by downregulating AEG1 in glioblastoma cancer cells.

20. The findings demonstrated that miR-379 may play tumor-suppressing roles in glioma through downregulation of MTDH and regulation of the PTEN/AKT signaling pathway.