Metadherin Proteine (MTDH)

Mouse (Murine) Metadherin (MTDH) Interaktionspartner

1. Data show MTDH mRNA expression upregulated in cervical cancer tissues and inversely correlated with miR (zeige MLXIP Proteine)-433 expression. Its knockdown showed similar tumor-suppressive roles as miR (zeige MLXIP Proteine)-433 overexpression in regards to cervical cancer cell proliferation, invasion and apoptosis. MTDH overexpression markedly reversed the effects of miR (zeige MLXIP Proteine)-433 overexpression in regards to proliferation, invasion and of cervical cancer cells.

2. Up regulation of AEG protein plays a role in the pathogenesis of NAFLD.

3. miR (zeige MLXIP Proteine)-26a is capable of suppressing the proliferation and migration of ESCC cells via negative regulation of metadherin

4. Mtdh is a potent modulator of podocyte apoptosis.

5. AEG-1 thus might play a role in NTIS associated with HCC (zeige FAM126A Proteine) and other cancers.

6. When fed a high fat and cholesterol diet (HFD), WT mice rapidly gained weight, whereas AEG-1 KO mice did not gain weight at all.

7. MTDH has a critical role in male fertility and the DNA repair mechanisms required for normal spermatogenesis

8. Data provide evidence that MTDH has a functional role in the progression and metastatic spread of ovarian cancer.

9. RNA-sequencing analysis identified a unique gene signature in livers of Alb (zeige ALB Proteine)/AEG-1/c-Myc (zeige MYC Proteine) mice that was not observed when either AEG-1 or c-Myc (zeige MYC Proteine) was overexpressed

10. Findings establish a pivotal role for MTDH in prostate cancer progression and metastasis.

Human Metadherin (MTDH) Interaktionspartner

1. High MTDH expression is associated with colorectal cancer.

2. miR (zeige MLXIP Proteine)-655 directly targets and downregulates MTDH mRNA expression in oral squamous cell carcinoma cells.

3. Metadherin (MTDH) was validated as a direct target gene of miR874 in retinoblastoma cells.

4. AEG-1 as a target gene of miR (zeige MLXIP Proteine)-216b action.

5. AEG-1 participates in the effects of miR (zeige MLXIP Proteine)-625-3p on thyroid cancer cells.

6. Findings provide the first evidence that the aberrant expression of miR (zeige MLXIP Proteine)-136 may be implicated into carcinogenesis and cancer progression of OS. Functionally, miR (zeige MLXIP Proteine)-136 may inhibit the proliferation, migration and invasion of OS cells via negatively regulating its target gene MTDH.

7. AEG-1 was found to be significantly associated with hypoxia in ovarian cancer by regulating the HIF-1alpha (zeige HIF1A Proteine)/NF-kappaB (zeige NFKB1 Proteine)/VEGF (zeige VEGFA Proteine) pathway.

8. Reduction of TUG1 level suppressed cell growth and metastasis by regulating AEG1 expression mediated by targeting miR (zeige MLXIP Proteine)-129-5p.

9. miR96 may impede the epithelial to mesenchymal transition process by downregulating AEG1 in glioblastoma cancer cells.

10. The findings demonstrated that miR (zeige MLXIP Proteine)-379 may play tumor-suppressing roles in glioma through downregulation of MTDH and regulation of the PTEN/AKT (zeige AKT1 Proteine) signaling pathway.