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Cathepsin B Proteine

(Cathepsin B (CTSB))
The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

Gesetzte Filter:

  • Target: Cathepsin B (CTSB)
  • Protein
Catalog no. Produkt Reaktivität Wirt / Klonalität Anwendung Preis & Lieferzeit
ABIN7959403
Cathepsin B Protein (CTSB) (His tag) CTSB · Protein Human Human Cells
878,90 € Preis anzeigen
  • 50 μg
  • 1 mg
  • 500 μg
Lieferung in 12 bis 17 Werktagen Lieferung nach: Deutschland
ABIN7819933
Cathepsin B Protein (CTSB) (AA 51-339) (His tag) CTSB · Protein Maus Bacteria
361,90 € Preis anzeigen
  • 100 μg
Lieferung in 4 bis 5 Werktagen Lieferung nach: Deutschland
Protein
Spezies
Human
Wirt
Human Cells
Protein-Typ
Recombinant
Reinheit
Greater than 95 % as determined by reducing SDS-PAGE.
Produktnummer ABIN7959403
878,90 €
Zzgl. Versandkosten 20,00 € und MwSt
50 μg (Weitere Mengeneinheiten)
Lieferung nach: Deutschland
Lieferung in 12 bis 17 Werktagen
Protein
Spezies
Maus
Wirt
Bacteria
Protein-Typ
Recombinant
Produktnummer ABIN7819933
361,90 €
Zzgl. Versandkosten 20,00 €, Trockeneispauschale 20,00 € sowie MwSt
100 μg
Lieferung nach: Deutschland
Lieferung in 4 bis 5 Werktagen

Aktuelle Publikationen für unsere Cathepsin B Proteine

Hartmann, Lopez Cruz, Alameh, Ho, Rabideau, Pentelute, Bradley, Martchenko: "Characterization of Novel Piperidine-Based Inhibitor of Cathepsin B-Dependent Bacterial Toxins and Viruses." in: ACS infectious diseases, Vol. 4, Issue 8, pp. 1235-1245, (2018) (PubMed).

Peng, Zhang, Zheng, Liang, Li, Chen, Guo, Yoshina, Chen, Zhao, Wu, Liu, Mitani, Yu, Xue: "Cysteine protease cathepsin B mediates radiation-induced bystander effects." in: Nature, Vol. 547, Issue 7664, pp. 458-462, (2017) (PubMed).

Zilbermintz, Leonardi, Jeong, Sjodt, McComb, Ho, Retterer, Gharaibeh, Zamani, Soloveva, Bavari, Levitin, West, Bradley, Clubb, Cohen, Gupta, Martchenko: "Identification of agents effective against multiple toxins and viruses by host-oriented cell targeting." in: Scientific reports, Vol. 5, pp. 13476, (2015) (PubMed).

Chowdhury, Moya, Bhilocha, McMillan, Vigliarolo, Zehbe, Phenix: "Prodrug-inspired probes selective to cathepsin B over other cysteine cathepsins." in: Journal of medicinal chemistry, Vol. 57, Issue 14, pp. 6092-104, (2014) (PubMed).

Zhao, Hua, Crowley, Ru, Ni, Shaw, Jiao, Ding, Qu, Hung, Huang, Liu, Ye, Ouyang, Cheng, Liu: "Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage." in: Cell research, Vol. 24, Issue 3, pp. 344-58, (2014) (PubMed).

Cao, Taggart, Berquin, Moin, Fong, Sloane: "Human gastric adenocarcinoma cathepsin B: isolation and sequencing of full-length cDNAs and polymorphisms of the gene." in: Gene, Vol. 139, Issue 2, pp. 163-9, (1994) (PubMed).

Chan, San Segundo, McCormick, Steiner: "Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 20, pp. 7721-5, (1986) (PubMed).

Aliase für Cathepsin B Proteine

cathepsin B (CTSB) Proteine
cathepsin B (Ctsb) Proteine
cathepsin B S homeolog (ctsb.S) Proteine
cathepsin B (LOC692390) Proteine
APPS Proteine
apps Proteine
CB Proteine
CPSB Proteine
cpsb Proteine
CTSB Proteine
LOC692390 Proteine
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