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Human Polyclonal XIAP Primary Antibody für IF (cc), IF (p) - ABIN674364
Chen, Bai, Zhong, Xie, Long, Yang, Wu, Jia, Wang: Wogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7? and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549. in PLoS ONE 2013
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Human Polyclonal XIAP Primary Antibody für IHC, ELISA - ABIN1003492
Schimmer: Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice. in Cancer research 2004
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Human Polyclonal XIAP Primary Antibody für IHC, IHC (p) - ABIN4366393
Lee, Jiffar, Kupferman: A novel role for BDNF-TrkB in the regulation of chemotherapy resistance in head and neck squamous cell carcinoma. in PLoS ONE 2012
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Human Polyclonal XIAP Primary Antibody für IHC (p), WB - ABIN3044425
Li, Zhang, Fang, Yan, Zhao, Feng, Ma, Ye: Aspirin overcomes Navitoclax-resistance in hepatocellular carcinoma cells through suppression of Mcl-1. in Biochemical and biophysical research communications 2013
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Human Polyclonal XIAP Primary Antibody für ICC, IF - ABIN4366395
Fann, Lee, Manzanero, Tang, Gelderblom, Chunduri, Bernreuther, Glatzel, Cheng, Thundyil, Widiapradja, Lok, Foo, Wang, Li, Drummond, Basta, Magnus, Jo, Mattson, Sobey, Arumugam: Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke. in Cell death & disease 2013
These results reveal that RPS3 (zeige RPS3 Antikörper) upregulates XIAP independently of the NF-kappaB (zeige NFKB1 Antikörper) pathway in human breast cancer cells
downregulation of XIAP expression could enhance the sensitivity of RCC (zeige XRCC1 Antikörper) cells to apoptosis, and the basal expression of XIAP during apoptosis is stable.
XIAP promotes ubiquitylation and degradation of Bcl-2 (zeige BCL2 Antikörper).
XIAP gene silencing would strengthen the radiosensitivity of esophageal cancer cells in vivo and in vitro, which provides a novel (zeige CASP3 Antikörper)target for the (zeige CASP9 Antikörper) treatment of esophageal cancer.
Findings of the study confirm that L-THP (zeige UMOD Antikörper) resulted in p53 (zeige TP53 Antikörper) independent apoptosis via down-regulating XIAP protein by inhibiting MDM2 (zeige MDM2 Antikörper) associated with proteasome-dependent pathway and increased sensitivity of EU-4 cells against doxorubicin.
miR (zeige MLXIP Antikörper)-23a induces trophoblast cell apoptosis by inhibiting XIAP, which may contribute to Preeclampsia.
These data suggest that XIAP may be playing an important role in the pathogenesis of breast cancer and can be therapeutically targeted either alone or in combination with PI3-kinase (zeige PIK3CA Antikörper) inhibition to induce efficient apoptosis in breast cancer cells.
loss of XIAP enhances filopodia formation in a Cdc42-dependent manner and this phenomenon phenocopies EGF stimulation. Further, XIAP depletion promotes lung colonization of tumor cells in mice in a Cdc42-dependent manner. These observations shed molecular insights into ubiquitin-dependent regulation of Cdc42 and that of actin cytoskeleton.
XIAP role in the cisplatin resistance in colon cancer
Here, the authors show that transcriptional regulator interacting with the PHD-bromodomain 1 (TRIP-Br1 (zeige SERTAD1 Antikörper), Sertad1 (zeige SERTAD1 Antikörper)), a newly identified protein with poorly characterized functions, acts as an adaptor that bridges the interaction of multiple Adenylyl cyclase isoforms with X-linked inhibitor of apoptosis protein (XIAP), a RING-domain E3 ubiquitin ligase (zeige MUL1 Antikörper).
mRNA and protein expressions of XIAP were decreased via siRNA targetting, which leads to increases in cell apoptosis and caspase-3 (zeige CASP3 Antikörper) and caspase-9 (zeige CASP9 Antikörper) activity. It also contributed to the reduced tumor size and tumor weight in a nude mice model of esophageal cancer.
The neuron-specific form of FAIM (zeige FAIM Antikörper) protein (FAIM (zeige FAIM Antikörper)-L) is a death receptor antagonist that stabilizes XIAP protein levels, thus preventing death receptor-induced neuronal apoptosis. Here we show that FAIM (zeige FAIM Antikörper)-L modulates synaptic transmission, prevents chemical-LTD induction in hippocampal neurons, and thwarts axon degeneration after nerve growth factor (NGF) withdrawal.
These data reveal how, upon XIAP deficiency, a TLR-TNF (zeige TNF Antikörper)-TNFR2 (zeige TNFRSF1B Antikörper) axis drives cIAP1 (zeige BIRC2 Antikörper)-TRAF2 (zeige TRAF2 Antikörper) degradation to allow TLR or TNFR1 (zeige TNFRSF1A Antikörper) activation of RIPK3 (zeige RIPK3 Antikörper)-caspase-8 (zeige CASP8 Antikörper) and IL-1beta (zeige IL1B Antikörper). This mechanism may explain why XIAP-deficient patients can exhibit symptoms reminiscent of patients with activating inflammasome mutations.
There was a significantly decreased percentage of IL-17A (zeige IL17A Antikörper)-producing CD4 (zeige CD4 Antikörper) T cells in mice receiving Tregs from xIAP mice. xIAP appears dispensable for the generation of induced Treg cells as well as function of natural Treg cells. There appeared to be a role of xIAP in generation of IL-17 (zeige IL17A Antikörper)-producing cells from either naive CD4 (zeige CD4 Antikörper) T cells or Treg cells.
Drugs targeting XIAP and cIAP1 (zeige BIRC2 Antikörper)/2 may be effective for osteosarcoma patients whose tumors express abundant RIPK1 (zeige RIPK1 Antikörper) and contain high levels of TNFalpha (zeige TNF Antikörper).
Deletion of XIAP switches cell death away from necrosis to apoptosis.
These results indicate that XIAP plays an important physiologic role in regulating sublethal CASP-3 (zeige CASP3 Antikörper) activity within central neurons and thereby facilitates synaptic plasticity and memory acquisition.
XIAP antagonizes the switch from TNFalpha (zeige TNF Antikörper)-induced apoptosis to necroptosis in mouse neutrophils.
Results show that XIAP binds to the C terminus of Ptch1 (zeige PTCH1 Antikörper) and mediates the death-dependent function of Ptch1 (zeige PTCH1 Antikörper).
XIAP modulates ubiquitylation of RIP1 (zeige RALBP1 Antikörper) and suppresses RIP3 (zeige MPRIP Antikörper)-dependent cell death and inflammasome activation in response to TNF (zeige TNF Antikörper)-signaling in innate immune cells.
This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.
E3 ubiquitin-protein ligase XIAP
, IAP-like protein
, X-linked IAP
, baculoviral IAP repeat-containing protein 4
, inhibitor of apoptosis protein 3
, Baculoviral IAP repeat-containing protein 4
, X-linked inhibitor of apoptosis protein
, baculoviral IAP repeat-containing 4
, baculoviral IAP-repeat containing protein 4
, IAP homolog A
, apoptosis inhibitor 3
, apoptosis inhibitor protein 3
, baculoviral IAP repeat containing 8