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Human PARP1 Protein expressed in Baculovirus - ABIN1741730
Woodhouse, Dianov: Poly ADP-ribose polymerase-1: an international molecule of mystery. in DNA repair 2008
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Human PARP1 Protein expressed in Baculovirus - ABIN1741729
Lamarre, Talbot, de Murcia, Laplante, Leduc, Mazen, Poirier: Structural and functional analysis of poly(ADP ribose) polymerase: an immunological study. in Biochimica et biophysica acta 1988
Show all 9 Pubmed References
Potential high binding affinity compounds that are predicted by molecular simulations were then tested by in vitro methods. Computationally proposed compounds as PARP-1 inhibitors were confirmed by in vitro studies. In vitro results showed that compounds 7111620047 and 7119980926 have IC50 values of 0.56 and 63 muM against PARP-1 target, respectively
The impairment of PARP-dependent DNA damage response (DDR (zeige DDR1 Proteine)) signaling due to mutations in the FUS (zeige FUS Proteine) nuclear localization sequence induces additional cytoplasmic FUS (zeige FUS Proteine) mislocalization which in turn results in neurodegeneration and FUS (zeige FUS Proteine) aggregate formation in amyotrophic lateral sclerosis.
Septin4 is a novel essential factor involved in oxidative stress induced (zeige SQSTM1 Proteine) vascular endothelial cell injury by interacting with apoptosis-related protein PARP1.
Data show that the mRNA level of poly(ADP-ribose) polymerase (PARP)-1 was significantly regulated by miR (zeige MLXIP Proteine)-216b.
The Gene expression levels of PARP1 was robustly elevated in oligodendrocytes laser captured from BA10 and amygdala white matter of Major Depressive Disorder.
PARP-1 activates prothrombin (zeige F2 Proteine) gene transcription and that the excessive prothrombin (zeige F2 Proteine) gene transcription induces des (zeige DES Proteine)-gamma-carboxy prothrombin (zeige F2 Proteine) (DCP (zeige ACE Proteine)) production in DCP (zeige ACE Proteine)-producing hepatocellular carcinoma cells.
Sodium arsenite induces S-nitrosation on PARP-1 zinc finger DNA binding domain by generating NO through iNOS (zeige NOS2 Proteine) activation, leading to zinc loss and inhibition of PARP-1 activity, thereby increasing retention of damaged DNA.
PARP1 inhibition potentiated trabectedin activity in a PARP1-dependent manner and PARP1 expression in tumor cells might be a useful predictive biomarker that deserves clinical evaluation
Androgen receptor (AR (zeige AR Proteine)) regulates homologous recombination and AR inhibition activates the PARP pathway in vivo.
This study is the first to investigate the combination of PARP inhibitors with cytotoxic chemotherapy in acute leukemias in the clinical setting
A stimulation induced PARP1 binding to phosphorylated Erk2 (zeige MAPK1 Proteine) in the chromatin of cerebral neurons caused Erk (zeige EPHB2 Proteine)-induced PARP1 activation, rendering transcription factors and promoters of immediate early (zeige JUN Proteine) genes (IEG) accessible to PARP1-bound phosphorylated Erk2 (zeige MAPK1 Proteine).
The present work identifies several microglial responses to the endogenous alarmin S100B (zeige S100B Proteine), including release of the cytotoxic protease MMP9 (zeige MMP9 Proteine) and shows that these effects are modulated by PARP-1.
flavonoids of Rosa roxburghii Tratt enhanced radioprotection at least partially by regulating PARP-1/AIF (zeige AIFM1 Proteine) to reduce apoptosis.
These data demonstrate the presence of an FAF1 (zeige FAF1 Proteine)-PARP1 axis that is involved in oxidative stress-induced (zeige SQSTM1 Proteine) necrosis and in the pathology of Parkinson's disease.
Data indicate that poly(ADP-ribose)polymerase 1 (PARP1) D993A/D993A mice and cells are viable and show no obvious abnormalities.
Telomere-internal double-strand breaks (DSBs) are also repaired by a PARP1- and Ligase3-dependent reaction, suggesting alternative non-homologous end-joining (alt-NHEJ), which relies on microhomology at DSBs.
post-translational modification facilitates the mobilization of SIRT6 (zeige SIRT6 Proteine) to DNA damage sites and is required for efficient recruitment of poly (ADP-ribose) polymerase 1 (PARP1) to DNA break sites and for efficient repair of double-strand break.
Data show that Tp53 (zeige TP53 Proteine)- and Atm (zeige ATM Proteine)-defective Chronic lymphocytic leukemia (CLL) mimicking the high-risk form of human disease and that Atm (zeige ATM Proteine)-deficient CLL is sensitive to PARP1 inhibition.
The results suggest that ATRX (zeige ATRX Proteine) is required to limit replication stress during cellular proliferation, whereas upregulation of PARP-1 activity functions as a compensatory mechanism to protect stalled forks, limiting genomic damage, and facilitating late-born neuron production.
No increase of axonal regeneration was observed in Parp1(-/-) mice after optic nerve crush injury or dorsal hemisection of the thoracic spinal cord, and there was no improvement in motor function recovery. Comprehensive in vivo analysis reveals no indication that clinical PARP inhibitors will on their own provide benefit for recovery from central nervous system trauma.
The results demonstrate that PARylation process in Drosophila is tightly regulated in the context of strands-breaks repair; PARP is essential during the maintenance of DNA integrity, but dispensable in the DNA repair process.
A mutation of Parp also increases NAD+ levels; although, this was only observed in parkin (zeige PARK2 Proteine) mutant flies and not in the heterozygous Parp mutants, possibly owing to an increased PARP activity in the parkin (zeige PARK2 Proteine) mutants.
chromatin loosening and associated initiation of gene expression is activated by phosphorylation of H2Av (zeige H2AFV Proteine) in a nucleosome positioned in promoter regions of PARP-1-dependent genes
Based on these findings, we propose a model that explains how PARP1 activity impacts nucleolar functions and, consequently, ribosomal biogenesis
PARP is associated with the 5' end of Hsp70, and its enzymatic activity is rapidly induced by heat shock leading to nucleosome loss.
Activation of PARP-1 overexpression in the imago results in extension of the lifespan in females and males. The lifespan increase in females with PARP-1 conditional overexpression was accompanied by decrease of fertility.
PARP1 is targeted to chromatin by association with the histone H2A variant (H2Av).
demonstrate that this alteration specifically excludes PARP1 protein from heterochromatin and makes PARP1 unable to maintain repression of retrotransposable elements.
PARP-e autoregulates Parp transcription
propose that chromosomal PARP molecules become activated by developmental or environmental cues and strip nearby chromatin proteins off DNA to generate a puff
no difference was found in the level of SBDP145 between muscles, while SBDP120 and PARP-1 cleavage products were not detected
ADPRT Val762Ala and APE1 (zeige APEX1 Proteine) Asp148Glu polymorphisms are not associated with increased breast cancer risk
analysis of poly(ADP-ribose) polymerase 1 interaction with apurinic/apyrimidinic sites
FGF2 (zeige FGF2 Proteine) stimulates poly(ADP-ribose) polymerase activity by a DNA strand breaks-independent manner which involves a mitogen-activated protein kinases (MAPK (zeige MAPK1 Proteine))-dependent pathway
The transcript levels of autophagy-related genes and poly(ADP-ribose) polymerase 1 (PARP1), were transiently up-regulated by fertilization, decreased at the late 1-cell stage, and maintained until the blastocyst stage.
The PARP1 signaling pathway is involved in oocyte nest breakdown and primordial follicle formation in fetal and neonatal porcine ovaries, but is different from follicular atresia in adult porcine ovaries that involves cellular apoptosis.
Cleavage of PARP-1 by activated (cleaved) caspase-3 (zeige CASP3 Proteine) may serve a key role in controlling follicular atresia through granulosa cell degeneration.
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)
, ADP-ribosyltransferase NAD(+)
, ADP-ribosyltransferase diphtheria toxin-like 1
, NAD(+) ADP-ribosyltransferase 1
, poly (ADP-ribose) polymerase family, member 1
, poly [ADP-ribose] polymerase 1
, poly(ADP-ribose) polymerase
, poly(ADP-ribose) synthetase
, poly[ADP-ribose] synthase 1
, ADP-ribosyltransferase (NAD+
, ADP-ribosyltransferase 1
, ADPRT 1
, poly (ADP-ribose) polymerase)
, poly(ADP-ribose) polymerase PARP-1
, poly[ADP-ribose] synthetase 1
, ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1
, ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 1
, Poly(ADP ribose) polymerase 1
, Poly(ADP)-Ribose polymerase
, Poly(ADP-)Ribose polymerase
, Poly(ADP-ribose) polymerase
, Poly(ADP-ribose) polymerase 1
, ADP-ribosyltransferase (NAD+) poly (ADP-ribose) polymerase)
, Poly[ADP-ribose] synthase 1
, LOW QUALITY PROTEIN: poly [ADP-ribose] polymerase 1