anti-DR4 (DR4) Antikörper

Bezeichnung:: anti-Drought-Repressed 4 Protein Antikörper (DR4)

Auf www.antikoerper-online.de finden Sie aktuell 58 Drought-Repressed 4 Protein (DR4) Antikörper von 14 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 68 DR4 Produkte verfügbar.

Synonyme:: APO2, CD261, DR4, TRAILR-1, TRAILR1

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	DR4	8797	O00220
	DR4
	DR4
Alle Spezies anzeigen Weitere Synonyme anzeigen

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anti-Human DR4 Antikörper:

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Verknüpfte Pathways mit anti-DR4 Antikörper

Weitere Antikörper gegen DR4 Interaktionspartner

Human Drought-Repressed 4 Protein (DR4) Interaktionspartner

In contrast to apoptosis, necroptotic signaling was activated similarly by both DR4 (zeige HLADRB4 Antikörper)- or DR5 (zeige TNFRSF10B Antikörper)-specific ligands..Our study provides the first systematic insight into DR4 (zeige HLADRB4 Antikörper)-/DR5 (zeige TNFRSF10B Antikörper)-specific signaling in colorectal and pancreatic cancer cells
We found that pharmacological application of Golgi stress leads to induction of death receptors (DRs (zeige PNN Antikörper)) 4 and 5. DR4 (zeige HLADRB4 Antikörper) appears to be primarily responsible for the initiation of cell death downstream of Golgi stress, whereas DR5 (zeige TNFRSF10B Antikörper) seems to be more important for cell death triggered by endoplasmic reticulum (ER) stress in specific cancer cell lines
our results demonstrated that nanovectorization of TRAIL with BNNTs enhanced its binding to both DR4 (zeige HLADRB4 Antikörper) and DR5 (zeige TNFRSF10B Antikörper) receptors at 37 degrees C. Our novel nanovector could potentially be used for delivering TRAIL to cells for cancer treatment
By downregulating TRAIL-R1, TGFbeta1 (zeige TGFB1 Antikörper) may not only promote tumor escape from immune surveillance but also negatively impact on TRAIL- or TRAIL-R1-based therapy regimens for treatment of Pancreatic ductal adenocarcinoma.
Results show that downregulation of DR4 (zeige HLADRB4 Antikörper) and DR5 (zeige TNFRSF10B Antikörper) by SLC26A2 (zeige SLC26A2 Antikörper) confers resistance to TRAIL.
BAY61-3606 sensitizes colon cancer cells to TRAIL-induced apoptosis by up-regulating DR4 (zeige HLADRB4 Antikörper) expression in p53 (zeige TP53 Antikörper)-dependent manner and inhibiting NF-kappaB (zeige NFKB1 Antikörper) activity.
findings together highlight a previously undiscovered mechanism that positively regulates DR4 (zeige HLADRB4 Antikörper) expression through activation of the MEK (zeige MAP2K1 Antikörper)/ERK (zeige EPHB2 Antikörper)/AP-1 (zeige FOSB Antikörper) signaling pathway.
results suggest that the altered TRAIL, DR4 (zeige HLADRB4 Antikörper) alleles and sTRAIL levels may be associated with some other potential biomarkers for vitiligo (zeige MITF Antikörper)
The nanovectorization of TRAIL enhanced its binding to both DR4 (zeige HLADRB4 Antikörper) and DR5 (zeige TNFRSF10B Antikörper) receptors at 37 degrees C and could potentially sensitized cancer cells to TRAIL induced apoptosis through simultaneous activation of DR4 (zeige HLADRB4 Antikörper) and DR5 (zeige TNFRSF10B Antikörper) as described in this paper for the non-small lung carcinoma cell line (H1703), the two hepatocarcinoma cell lines (SK-Hep1, HUH) and the colon carcinoma cell line (HCT116WT).
Pro-survival effects by NF-kappaB (zeige NFKB1 Antikörper), Akt (zeige AKT1 Antikörper) and ERK(1 (zeige MAPK3 Antikörper)/2) and anti-apoptosis actions by Six1 (zeige SIX1 Antikörper) disrupt apoptotic functions of TRAIL-Dr4 (zeige HLADRB4 Antikörper)/5 pathway in ovarian cancer, which may explain why up-regulated DR4 (zeige HLADRB4 Antikörper) and DR5 (zeige TNFRSF10B Antikörper) in ovarian cancer are associated with poor prognosis and low survival ratio of the patients.

DR4 Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.

Alternative names and synonyms associated with DR4

TNF receptor superfamily member 10a (TNFRSF10A) Antikörper

APO2 Antikörper
CD261 Antikörper
DR4 Antikörper
TRAILR-1 Antikörper
TRAILR1 Antikörper

Bezeichner auf Proteinebene für DR4

TNF-related apoptosis-inducing ligand receptor 1 , TRAIL receptor 1 , TRAIL-R1 , cytotoxic TRAIL receptor , death receptor 4 , tumor necrosis factor receptor superfamily member 10A , tumor necrosis factor receptor superfamily member 10a variant 2

GENE ID	SPEZIES
8797	Homo sapiens

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