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Human Polyclonal BCL2L1 Primary Antibody für ELISA, IF (p) - ABIN675129
Wang, Ma, Su: NF-?B pathway contributes to cadmium-induced apoptosis of porcine granulosa cells. in Biological trace element research 2013
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Human Polyclonal BCL2L1 Primary Antibody für IP, WB - ABIN223050
Cordiali-Fei, Ardigo, Mastroianni, Giuliani, D Agosto, Bordignon, Trento, Vento, Berardesca: Serum cytokines and biohumoral immunological characterization of psoriatic patients in long term etanercept treatment. in International journal of immunopathology and pharmacology 2008
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Human Polyclonal BCL2L1 Primary Antibody für IHC - ABIN965653
Cheng, Levine, Boise, Thompson, Hardwick: Bax-independent inhibition of apoptosis by Bcl-XL. in Nature 1996
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Human Monoclonal BCL2L1 Primary Antibody für FACS - ABIN135024
Chittenden, Harrington, OConnor, Flemington, Lutz, Evan, Guild: Induction of apoptosis by the Bcl-2 homologue Bak. in Nature 1995
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Human Monoclonal BCL2L1 Primary Antibody für FACS, IHC - ABIN440456
Punnoose, Leverson, Peale, Boghaert, Belmont, Tan, Young, Mitten, Ingalla, Darbonne, Oleksijew, Tapang, Yue, Oeh, Lee, Maiga, Fairbrother, Amiot, Souers, Sampath: Expression Profile of BCL-2, BCL-XL, and MCL-1 Predicts Pharmacological Response to the BCL-2 Selective Antagonist Venetoclax in Multiple Myeloma Models. in Molecular cancer therapeutics 2016
Human Monoclonal BCL2L1 Primary Antibody für IF, PLA - ABIN560043
Türkmen, Riehn, Klopocki, Molkentin, Reinhardt, Burmeister: A BACH2-BCL2L1 fusion gene resulting from a t(6;20)(q15;q11.2) chromosomal translocation in the lymphoma cell line BLUE-1. in Genes, chromosomes & cancer 2011
Human Polyclonal BCL2L1 Primary Antibody für IHC, IHC (fro) - ABIN4283629
Krajewska, Rosenthal, Mikolajczyk, Stennicke, Wiesenthal, Mai, Naito, Salvesen, Reed, Fiskum, Krajewski: Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation. in Experimental neurology 2004
Human Monoclonal BCL2L1 Primary Antibody für WB - ABIN1882212
Ban, Eckhart, Weninger, Mildner, Tschachler: Identification of a human cDNA encoding a novel Bcl-x isoform. in Biochemical and biophysical research communications 1998
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In this study, we investigated whether APG (zeige SMAD1 Antikörper)-1252-12A inhibits the growth of five leukemia cell lines in a concentration- or time-dependent manner by MTS (zeige TIMM8A Antikörper) assay.APG-1252-12A is a Bcl-2 (zeige BCL2 Antikörper) homology (BH)-3 mimetic that specifically binds to Bcl-2 (zeige BCL2 Antikörper) and Bcl-xl, which has shown efficacy in some Bcl-2 (zeige BCL2 Antikörper) dependent hematological cancers
inhibition of Bcl-xL induces significantly more apoptosis in IDH1 (zeige IDH1 Antikörper)-mutated cells than in wild-type IDH1 (zeige IDH1 Antikörper) cells.
CCAT1 is upregulated in docetaxel-resistant lung adenocarcinoma cells; its oncogenic function depends on sponging of let-7c, which releases Bcl-xl, promoting the acquisition of chemoresistance and epithelial-to-mesenchymal transition phenotypes
In the epithelial ovarian cancer stem cells, 40% knock-down of Bclxl expression was sufficient to induce the full activation of caspases. Bclxl expression levels in EOC cells is dynamic and can be regulated by microenvironments that are enriched with the pro-inflammatory cytokine IL-6 (zeige IL6 Antikörper) such as the cancer stem cell and adipocyte niches.
Study reports the interaction of BCL-XL with RASSF6 (zeige RASSF6 Antikörper). BCL-XL inhibits the interaction between RASSF6 (zeige RASSF6 Antikörper) and MDM2 (zeige MDM2 Antikörper) and suppresses p53 (zeige TP53 Antikörper) expression. Consequently, BCL-XL antagonizes RASSF6 (zeige RASSF6 Antikörper)-mediated apoptosis. Thus, the inhibition of RASSF6 (zeige RASSF6 Antikörper)-mediated apoptosis also underlies the prosurvival role of BCL-XL.
anti-apoptotic molecules BclxL and Bcl-2 (zeige BCL2 Antikörper) and the pro-apoptotic factors BAD and BID (zeige BID Antikörper) cooperate to promote migration of triple-negative breast cancer cells stimulated with cl-CD95L (zeige FASL Antikörper).
These results show that mRNA expression in centenarians is unique and reveals that Bcl-xL plays an important role in exceptional aging.
that Ubiquitin-specific peptidase 18 (zeige USP18 Antikörper) directly bind to BCL2L1 and positively regulated its expression in hepatocellular carcinoma cells
High BCL-XL expression is associated with breast cancer.
The the expression of the full-length, wildtype form of PRMT2 (zeige PRMT2 Antikörper) promotes an increase in the BCL-X(L)/BCL-X(s) ratio in TNF-alpha (zeige TNF Antikörper) or LPS (zeige IRF6 Antikörper) stimulated cells.
GATA-3 (zeige GATA3 Antikörper) participates in the healing of bone fractures via regulating bcl-xL gene expression, owing to its association with Runx2 (zeige RUNX2 Antikörper).
this study demonstrates that necrosis of Mycobacterium tuberculosis-infected macrophages is dependent on the action of Bcl-xl
Mitochondrial Bcl-xL is involved in maintaining mitochondrial respiratory capacity. Its deficiency causes oxidative stress, which is associated with an increased glycolytic capacity and balanced by an increased activity of the pentose phosphate pathway.
Proapoptotic proteins BIM (zeige BCL2L11 Antikörper) and PUMA (zeige BBC3 Antikörper) are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL.
BMP4 (zeige BMP4 Antikörper) promotes survival of neural stem/progenitor cells by enhancing the anti-apoptotic function of Bcl-xL via BMP4 (zeige BMP4 Antikörper)-Smad1 (zeige SMAD1 Antikörper)/5/8-Id1 (zeige ID1 Antikörper) signaling in the presence of FGF-2 (zeige FGF2 Antikörper).
We propose that the GC-induced mitochondrial accumulation of Bax (zeige BAX Antikörper) and the interaction between the GR and Bim (zeige BCL2L11 Antikörper), Bcl-xL and Bak (zeige BAK1 Antikörper) could play a role in the regulation of thymocyte apoptosis.
Bcl-xL is required for survival of post mitotic neurons throughout the developing spinal cord.
Atherosclerosis-associated endothelial cell apoptosis may partially result from downregulation of Bcl-Xl, through upregulation of miR (zeige MLXIP Antikörper)-876 that binds and suppresses translation of Bcl-Xl mRNA.
Bcl-xL is a driver in colorectal tumorigenesis and cancer progression.
amplification and characterization of partial regions of exons 2 and 3 of the bovine BCL2L1 gene
Data show that Bcl-x(L) expression is increased in the pulmonary artery undergoing chronic pulmonary vascular remodeling.
interleukin-6 (zeige IL6 Antikörper), endothelin ET-1 (zeige EDN1 Antikörper), and apoptotic Bak (zeige BAK1 Antikörper) and Bcl-XL genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
Bcl-xL was significantly decreased in haploid parthenotes compared with the diploid parthenotes. These results suggest that the haploid state affects apoptosis-related gene expression which results in increased apoptosis
CONCLUSION(S): (1) Apoptosis is involved in follicular atresia; (2) Bcl-2 (zeige BCL2 Antikörper) is induced by warm ischemia; and (3) cryopreservation insult does not alter the apoptotic signals with short tissue preparation time.
Bcl-Xl deamidation and methylation has a role in protein isoaspartate methyltransferase prevention of apoptosis induced by oxidative stress in endothelial cells
Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (zeige TNF Antikörper), IL-6 (zeige IL6 Antikörper), IL-12p40, IL-1beta (zeige IL1B Antikörper), and resulted in increased expression of the apoptosis initiator caspase-8 (zeige CASP8 Antikörper) and bcl2L1.
This study leads to conclude that BCLXL peak expression at the zygotic genome activation phase may be a requirement for embryo development
In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of BCL2L1 transcripts and protein depending on luteal stage.
repression of radiation-induced apoptosis by overexpression of Bcl-xL during embryonic development depends upon the timing of its expression and post-translational events that enable the protein to become effective
The bcl2l gene operates in the inhibition of cell death under direct regulation of a thyroid specific set of transcription factors
Zebrafish anti-apoptotic gene Bcl-xL can prevent aquatic birnavirus-induced cell death in fish cells without affecting expression of viral proteins.
transgenic overexpression of zfBLP1 or myeloid cell leukemia sequence 1a in zebrafish larvae interrupts regulation of the homeostatic balance between cell proliferation and programmed cell death during hepatogenesis and leads to liver hyperplasia
Bcl-xL can block post-apoptotic necrosis processes thereby rescuing betanodavirus-infected cells
Delta113p53 functions to antagonize p53 (zeige TP53 Antikörper)-induced apoptosis via activating bcl2L
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.
apoptosis regulator Bcl-X
, bcl-2-like protein 1
, protein phosphatase 1, regulatory subunit 52
, B-cell leukemia/lymphoma x
, anti-apoptosis regulatory protein
, B cell lymphoma 2 like
, B cell lymphoma like X
, BCL2-like protein 1
, anti-apoptotic Bcl-xL
, BCLX protein
, BCL2-like 1
, apoptosis regulator R11
, Bcl-xL-like protein 1