APOBEC3A Produkte
(Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3A (APOBEC3A))
Kategorien
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012].
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Ausgewählte APOBEC3A Kategorien
APOBEC3A Antikörper
High quality antibodies with extensive validation data.
Empfohlene APOBEC3A Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
ELISA, WB, IHC, IF, FACS
Validierungen
- (4)
Kat. Nr.
ABIN238645
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC (p)
Validierungen
- (2)
- (2)
Kat. Nr.
ABIN6923109
Menge
200 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB
Validierungen
- (5)
- (1)
Kat. Nr.
ABIN1881066
Menge
400 μL
Datenblatt
Datenblatt
Empfohlene APOBEC3A Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
- (1)
Kat. Nr.
ABIN3087958
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (1)
Kat. Nr.
ABIN2714811
Menge
20 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren APOBEC3A Produkten
: "HIV-1 Vpr induces interferon-stimulated genes in human monocyte-derived macrophages." in: PLoS ONE, Vol. 9, Issue 8, pp. e106418, (2014) (PubMed).: "Innate immune signaling induces high levels of TC-specific deaminase activity in primary monocyte-derived cells through expression of APOBEC3A isoforms." in: The Journal of biological chemistry, Vol. 285, Issue 36, pp. 27753-66, (2010) (PubMed).
: "Interaction of Vpx and apolipoprotein B mRNA-editing catalytic polypeptide 3 family member A (APOBEC3A) correlates with efficient lentivirus infection of monocytes." in: The Journal of biological chemistry, Vol. 285, Issue 16, pp. 12248-54, (2010) (PubMed).
: "APOBEC3 proteins mediate the clearance of foreign DNA from human cells." in: Nature structural & molecular biology, Vol. 17, Issue 2, pp. 222-9, (2010) (PubMed).
: "Effects of structural variations of APOBEC3A and APOBEC3B genes in chronic hepatitis B virus infection." in: Hepatology research : the official journal of the Japan Society of Hepatology, Vol. 39, Issue 12, pp. 1159-68, (2009) (PubMed).
: "APOBEC deaminases-mutases with defensive roles for immunity." in: Science in China. Series C, Life sciences / Chinese Academy of Sciences, Vol. 52, Issue 10, pp. 893-902, (2009) (PubMed).
: "Targeting APOBEC3A to the viral nucleoprotein complex confers antiviral activity." in: Retrovirology, Vol. 4, pp. 61, (2007) (PubMed).
: "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business." in: Trends in genetics : TIG, Vol. 19, Issue 4, pp. 207-16, (2003) (PubMed).
: "An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22." in: Genomics, Vol. 79, Issue 3, pp. 285-96, (2002) (PubMed).
Synonyme und alternative Namen zu APOBEC3A
apolipoprotein B mRNA editing enzyme catalytic subunit 3A (APOBEC3A), apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A (APOBEC3Z1), apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3Z1 (APOBEC3Z1), similar to ARP10 protein (APOBEC3A), apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A (APOBEC3A), A3A, APOBEC3A, APOBEC3Z1, ARP3, bK150C2.1, PHRBNBezeichner auf Proteinebene für APOBEC3A
- DNA dC->dU-editing enzyme APOBEC-3A
- phorbolin 1
- phorbolin-1
- probable DNA dC->dU-editing enzyme APOBEC-3A
- apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
- similar to ARP10 protein
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