LKB1 Antikörper

Produktnummer ABIN969424

Dieses Maus Monoklonal-Antikörper erkennt spezifisch LKB1 in WB, ELISA und FACS. Er zeigt eine Reaktivität gegenüber Human, Maus und Affe und wurde in 3+ Publikationen erwähnt.

Kurzübersicht für LKB1 Antikörper (ABIN969424)

Target: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Reaktivität: Human, Maus, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LKB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Klon: 4H12

Produktdetails anti-LKB1 Antikörper

Verwendungszweck: STK11 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human STK11 expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-LKB1 Antikörper (ABIN969424)

Al-Nashash, Fatoo, Mirza, Ahmed, Agrawal, Thakor, All: "Spinal cord injury detection and monitoring using spectral coherence." in: IEEE transactions on bio-medical engineering, Vol. 56, Issue 8, pp. 1971-9, (2009) (PubMed).

Shaw: "Tumor suppression by LKB1: SIK-ness prevents metastasis." in: Science signaling, Vol. 2, Issue 86, pp. pe55, (2009) (PubMed).

Cheng, Liu, Wang, Zou, Santiago, Garbitt, Gjoerup, Iglehart, Miron, Richardson, Hahn, Zhao: "SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis." in: Science signaling, Vol. 2, Issue 80, pp. ra35, (2009) (PubMed).

Details zu LKB1

Target: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Andere Bezeichnung: STK11

Hintergrund: Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.serine/threonine kinase 11,with two alternatively spliced isoforms,expressed in all tissues,strongly homolog of Xenopus early embryonic kinase 1 (XEEK1),tumor suppressor gene in hamartomas syndrome and in left sided colon carcinogenesis,mutated in sporadic testicular cancer,malignant melanomas and laryngeal tumors,playing a minor role in the development of ovarian carcinoma.LKB1 is a potential target for atherosclerosis and cancer and is shown to be mutated in patients with Peutz-Jeghers cancer syndrome. Tissue specificity: Ubiquitously expressed. Strongest expression in testis and fetal liver.

Molekulargewicht: 54 kDa

Gen-ID: 6794

UniProt: Q15831

Pathways: AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effekt