SKP1 Antikörper

Produktnummer ABIN969397

Dieses Maus Monoklonal-Antikörper erkennt spezifisch SKP1 in WB, ELISA, IHC, ICC und FACS. Er zeigt eine Reaktivität gegenüber Human und wurde in 1 Publikation erwähnt.

Kurzübersicht für SKP1 Antikörper (ABIN969397)

Target: SKP1 (S-Phase Kinase-Associated Protein 1 (SKP1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SKP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Klon: 4E11

Produktdetails anti-SKP1 Antikörper

Verwendungszweck: SKP1 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human SKP1 expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-SKP1 Antikörper (ABIN969397)

Werden, Lanchbury, Shattuck, Neff, Dufford, McFadden: "The myxoma virus m-t5 ankyrin repeat host range protein is a novel adaptor that coordinately links the cellular signaling pathways mediated by Akt and Skp1 in virus-infected cells." in: Journal of virology, Vol. 83, Issue 23, pp. 12068-83, (2009) (PubMed).

Details zu SKP1

Target: SKP1 (S-Phase Kinase-Associated Protein 1 (SKP1))

Andere Bezeichnung: SKP1

Hintergrund: This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.

Molekulargewicht: 19 kDa

UniProt: P63208

Pathways: Zellzyklus, Hedgehog Signalweg, Mitotic G1-G1/S Phases