PDGFRB Antikörper (Platelet-Derived Growth Factor Receptor, beta Polypeptide)

Details for Product anti-PDGFRB Antibody No. ABIN969346
Antigen
Reaktivität
Human, Maus
496
276
247
9
8
8
8
6
2
2
2
1
1
1
Wirt
Maus
430
90
4
2
1
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser PDGFRB Antikörper ist unkonjugiert
20
15
15
15
15
15
15
14
13
13
11
6
6
6
6
6
4
1
1
1
Applikation
ELISA, Western Blotting (WB)
312
159
126
90
79
59
56
16
15
9
8
4
2
2
1
1
Optionen
Immunogen Purified recombinant fragment of human PDGFRbeta expressed in E. Coli.
Klon 1A2
Isotyp IgG1
Reinigung Ascites
Antigen
Andere Bezeichnung PDGFRbeta (PDGFRB Antibody Abstract)
Hintergrund Platelet-derived growth factor receptor, beta polypeptide, also known as PDGFRB, PDGFRβ or CD140B. It is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. This family exist as several disulphide-bonded, dimeric isoforms (PDGF AA, PDGF AB, PDGF BB, PDGF CC and PDGF DD) that bind in a specific pattern to two closely related receptor tyrosine kinases, PDGF receptor α (PDGFRα) and PDGF receptor β (PDGFRβ). These growth factors are mitogens for cells of mesenchymal origin. PDGFRB is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor, all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
Molekulargewicht 190 kDa
Gen-ID 5159
HGNC 5159
Pathways Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Inositol Metabolic Process, Glycosaminoglycan Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling
Applikations-hinweise ELISA: 1:10000, WB: 1:500 - 1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C,-20 °C
Informationen zur Lagerung 4°C, -20°C for long term storage
Bilder des Herstellers
Image no. 1 for anti-Platelet-Derived Growth Factor Receptor, beta Polypeptide (PDGFRB) antibody (ABIN969346) Figure 1: Western blot analysis using PDGFRβ mouse mAb against NIH/3T3 cell lysate (1) .
Produkt verwendet in: Gredmark, Strååt, Homman-Loudiyi, Kannisto, Söderberg-Nauclér: "Human cytomegalovirus downregulates expression of receptors for platelet-derived growth factor by smooth muscle cells." in: Journal of virology, Vol. 81, Issue 10, pp. 5112-20, 2007 (PubMed).

Wilczynski, Chen, Chen, Howell, Shively, Alberts: "Expression and mutational analysis of tyrosine kinase receptors c-kit, PDGFRalpha, and PDGFRbeta in ovarian cancers." in: Human pathology, Vol. 36, Issue 3, pp. 242-9, 2005 (PubMed).

Hansen, Rönnstrand, Rorsman, Hellman, Heldin: "Association of coatomer proteins with the beta-receptor for platelet-derived growth factor." in: Biochemical and biophysical research communications, Vol. 235, Issue 3, pp. 455-60, 1997 (PubMed).