PAX6 Antikörper

Produktnummer ABIN969342

Produktdetails anti-PAX6 Antikörper

Target: PAX6 (Paired Box 6 (PAX6))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PAX6 Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS)

Verwendungszweck: PAX6 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human PAX6 expressed in E. Coli.

Klon: 1C8

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-PAX6 Antikörper (ABIN969342)

Zhang, Yamada, Fan, Bangaru, Lin, Yang: "The beta subunit of voltage-gated Ca2+ channels interacts with and regulates the activity of a novel isoform of Pax6." in: The Journal of biological chemistry, Vol. 285, Issue 4, pp. 2527-36, (2010) (PubMed).

Hingorani, Williamson, Moore, van Heyningen: "Detailed ophthalmologic evaluation of 43 individuals with PAX6 mutations." in: Investigative ophthalmology & visual science, Vol. 50, Issue 6, pp. 2581-90, (2009) (PubMed).

Mascarenhas, Young, Littlejohn, Yoo, Salgia, Lang: "PAX6 is expressed in pancreatic cancer and actively participates in cancer progression through activation of the MET tyrosine kinase receptor gene." in: The Journal of biological chemistry, Vol. 284, Issue 40, pp. 27524-32, (2009) (PubMed).

Details zu PAX6

Target: PAX6 (Paired Box 6 (PAX6))

Andere Bezeichnung: PAX6 (PAX6 Produkte)

Hintergrund: Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells .PAX6 is the most researched of the PAX genes and appears throughout the literature as a "master control" gene for the development of eyes and other sensory organs, certain neural and epidermal tissues as well as other homologous structures, usually derived from ectodermal tissues. This transcription factor is most famous for its use in the interspecifically induced expression of ectopic eyes and is of medical importance because heterozygous mutants produce a wide spectrum of ocular defects such as Aniridia in humans. This gene encodes paired box gene 6, one of many human homologues of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause aniridia as well as Peter's anomaly, both ocular diseases.

Molekulargewicht: 46 kDa

UniProt: P26367

Pathways: Peptide Hormone Metabolism, Carbohydrate Homeostasis