NFKBIB Antikörper

Produktnummer ABIN969314

Der Maus Monoklonal Anti-NFKBIB-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, NFKBIB in Proben von Human zu detektieren. Es sind 3+ Publikationen verfügbar.

Kurzübersicht für NFKBIB Antikörper (ABIN969314)

Target: NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NFKBIB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Klon: 7B4

Produktdetails anti-NFKBIB Antikörper

Verwendungszweck: NFKBIB Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human NFKBIB expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-NFKBIB Antikörper (ABIN969314)

Yerges, Klei, Cauley, Roeder, Kammerer, Moffett, Ensrud, Nestlerode, Marshall, Hoffman, Lewis, Lang, Barrett-Connor, Ferrell, Orwoll, Zmuda: "High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 24, Issue 12, pp. 2039-49, (2009) (PubMed).

Chen, Vallee, Wu, Vu, Sondek, Ghosh: "Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras." in: Molecular and cellular biology, Vol. 24, Issue 7, pp. 3048-56, (2004) (PubMed).

Abid, Schoots, Spokes, Wu, Mawhinney, Aird: "Vascular endothelial growth factor-mediated induction of manganese superoxide dismutase occurs through redox-dependent regulation of forkhead and IkappaB/NF-kappaB." in: The Journal of biological chemistry, Vol. 279, Issue 42, pp. 44030-8, (2004) (PubMed).

Details zu NFKBIB

Target: NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))

Andere Bezeichnung: NFKBIB

Hintergrund: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further IKBA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.Tissue specificity: Expressed in all tissues examined.

Molekulargewicht: 45 kDa

Gen-ID: 4793

UniProt: Q15653

Pathways: NF-kappaB Signalweg, Activation of Innate immune Response, Maintenance of Protein Location, Toll-Like Receptors Cascades