MMP 9 Antikörper

Produktnummer ABIN969288

Produktdetails anti-MMP 9 Antikörper

Target: MMP 9 (MMP9) (Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) (MMP9))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MMP 9 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Verwendungszweck: MMP9 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human MMP9 expressed in E. Coli.

Klon: 5G3

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-MMP 9 Antikörper (ABIN969288)

Bozzi, Inzitari, Sbardell, Monaco, Pavoni, Gioia, Marini, Morlacchi, Sciandra, Castagnola, Giardina, Brancaccio, Coletta: "Enzymatic processing of beta-dystroglycan recombinant ectodomain by MMP-9: identification of the main cleavage site." in: IUBMB life, Vol. 61, Issue 12, pp. 1143-52, (2009) (PubMed).

Lipari, Mauro, Tortorici, Burruano, Leone, Spatola, Gerbino, Buscemi, Teté: "Immunohistochemical and transcriptional expression of the matrix metalloproteinases MMP-2 and MMP-9 in normal and pathological human oral mucosa." in: Journal of biological regulators and homeostatic agents, Vol. 23, Issue 4, pp. 259-67, (2009) (PubMed).

Details zu MMP 9

Target: MMP 9 (MMP9) (Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) (MMP9))

Andere Bezeichnung: MMP9 (MMP9 Produkte)

Hintergrund:

Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.

Aliases: GELB, CLG4B, MMP-9, MANDP2

Molekulargewicht: 92kDa

Gen-ID: 4318

HGNC: 4318

UniProt: P14780

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events