FGFR1 Antikörper (AA 22-376)

Produktnummer ABIN969138

Dieses Anti-FGFR1-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von FGFR1 in ELISA. Geeignet für Human. Dieses Primary Antibody wurde in 3+ Publikationen zitiert.

Kurzübersicht für FGFR1 Antikörper (AA 22-376) (ABIN969138)

Target: FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FGFR1 Antikörper ist unkonjugiert

Applikation: ELISA

Klon: 3D4F7

Produktdetails anti-FGFR1 Antikörper

Bindungsspezifität: AA 22-376

Verwendungszweck: FGFR1 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant extracellular fragment of human FGFR1 (aa22-376) fused with hIgGFc tag expressed in HEK293 cells.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-FGFR1 Antikörper (ABIN969138)

Elbauomy Elsheikh, Green, Lambros, Turner, Grainge, Powe, Ellis, Reis-Filho: "FGFR1 amplification in breast carcinomas: a chromogenic in situ hybridisation analysis." in: Breast cancer research : BCR, Vol. 9, Issue 2, pp. R23, (2007) (PubMed).

Magnusson, Ronca, DellEra, Carlstedt, Jakobsson, Partanen, Dimberg, Claesson-Welsh: "Fibroblast growth factor receptor-1 expression is required for hematopoietic but not endothelial cell development." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 25, Issue 5, pp. 944-9, (2005) (PubMed).

Hu, Fang, Dunham, Prada, Stachowiak, Stachowiak: "90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling." in: The Journal of biological chemistry, Vol. 279, Issue 28, pp. 29325-35, (2004) (PubMed).

Details zu FGFR1

Target: FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))

Andere Bezeichnung: FGFR1

Hintergrund: Fibroblast growth factor receptor 1 (FGFR1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome, and CD331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. FGFR1 has been shown to be associated with Pfeiffer syndrome. It is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction.

Molekulargewicht: 92 kDa

UniProt: P11362

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Sensory Perception of Sound, Stem Cell Maintenance, S100 Proteine