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ATM Antikörper

Der Maus Monoklonal Anti-ATM-Antikörper wurde für ELISA validiert. Er ist geeignet, ATM in Proben von Human zu detektieren. Es ist 1 Publikation verfügbar.
Produktnummer ABIN968969

Kurzübersicht für ATM Antikörper (ABIN968969)

Target

Alle ATM Antikörper anzeigen
ATM (Ataxia Telangiectasia Mutated (ATM))

Reaktivität

  • 163
  • 73
  • 32
  • 2
  • 1
  • 1
Human

Wirt

  • 134
  • 25
  • 5
  • 2
Maus

Klonalität

  • 124
  • 42
Monoklonal

Konjugat

  • 89
  • 8
  • 7
  • 5
  • 5
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
Dieser ATM Antikörper ist unkonjugiert

Applikation

  • 78
  • 52
  • 43
  • 39
  • 28
  • 28
  • 27
  • 25
  • 23
  • 18
  • 8
  • 7
  • 4
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
ELISA

Klon

5C5
  • Verwendungszweck

    ATM Antibody

    Aufreinigung

    Ascitic fluid

    Immunogen

    Purified recombinant fragment of human ATM expressed in E. Coli.

    Isotyp

    IgG1
  • Applikationshinweise

    ELISA: 1/10000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Ascitic fluid containing 0.03 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Smirnov, Cheung: "ATM gene mutations result in both recessive and dominant expression phenotypes of genes and microRNAs." in: American journal of human genetics, Vol. 83, Issue 2, pp. 243-53, (2008) (PubMed).

  • Target

    ATM (Ataxia Telangiectasia Mutated (ATM))

    Andere Bezeichnung

    ATM

    Hintergrund

    The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates, thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.Tissue specificity: Found in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen, thymus, testis, ovary, small intestine, colon and leukocytes.

    Molekulargewicht

    351 kDa

    Gen-ID

    472

    UniProt

    Q13315

    Pathways

    p53 Signalweg, Apoptose, DNA Reparatur, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
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