IGFBP3 Antikörper (AA 101-210)

Produktnummer ABIN968565

Dieses Anti-IGFBP3-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von IGFBP3 in WB und IF. Geeignet für Human. Dieses Primary Antibody wurde in 4+ Publikationen zitiert.

Kurzübersicht für IGFBP3 Antikörper (AA 101-210) (ABIN968565)

Target: IGFBP3 (Insulin-Like Growth Factor Binding Protein 3 (IGFBP3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IGFBP3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Klon: 4-IGFBP

Produktdetails anti-IGFBP3 Antikörper

Bindungsspezifität: AA 101-210

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human IGFBP-3 aa. 101-210

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-IGFBP3 Antikörper (ABIN968565)

Campbell, Durham, Hayes, Suwanichkul, Powell: "Insulin-like growth factor-binding protein-3 binds fibrinogen and fibrin." in: The Journal of biological chemistry, Vol. 274, Issue 42, pp. 30215-21, (1999) (PubMed).

Janosi, Firth, Bond, Baxter, Delhanty: "N-Linked glycosylation and sialylation of the acid-labile subunit. Role in complex formation with insulin-like growth factor (IGF)-binding protein-3 and the IGFs." in: The Journal of biological chemistry, Vol. 274, Issue 9, pp. 5292-8, (1999) (PubMed).

Shang, Baumrucker, Green: "Signal relay by retinoic acid receptors alpha and beta in the retinoic acid-induced expression of insulin-like growth factor-binding protein-3 in breast cancer cells." in: The Journal of biological chemistry, Vol. 274, Issue 25, pp. 18005-10, (1999) (PubMed).

Cubbage, Suwanichkul, Powell: "Insulin-like growth factor binding protein-3. Organization of the human chromosomal gene and demonstration of promoter activity." in: The Journal of biological chemistry, Vol. 265, Issue 21, pp. 12642-9, (1990) (PubMed).

Details zu IGFBP3

Target: IGFBP3 (Insulin-Like Growth Factor Binding Protein 3 (IGFBP3))

Andere Bezeichnung: IGFBP-3

Hintergrund: Insulin-like growth factors (IGF) I and II are peptide hormones that regulate cellular proliferation and differentiation. Most circulating IGFs exist in 130-150 kDa ternary complexes containing IGF-Binding Protein-3 (IGFBP-3) and an 85 kDa glycoprotein, the acid-labile subunit (ALS). IGFBP-3 is one of six IGFBPs that, by binding IGF peptides, prolong their half life and maintain the IGF reservoir. IGFBP-3 is found in body fluids as multiple 40-50 kDa forms as a result of differential glycosylation. The expression of IGFBP-3 in many tissues suggests that it locally modulates the autocrine/paracrine action of IGF peptides. IGFBP-3 binding to fibrinogen may be important for wound healing, since this concentrates IGF-I at wound sites and lowers the affinity of IGF-I for IGFBP-3. In addition, retinoic acid-induced IGFBP-3 expression inhibits the growth promoting effects of IGF-I in breast cancer cells. This may link the retinoid and IGF systems in cell growth regulation and explain how the loss of retinoic acid receptor beta leads to breast cancer progression. Thus, IGFBP-3 maintenance and regulation of IGF activity in various tissues may have diverse physiological roles.
Synonyms: IGF-Binding Protein-3

Molekulargewicht: 40 & 44 kDa

Pathways: Myometrial Relaxation and Contraction, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Autophagie, Smooth Muscle Cell Migration, Growth Factor Binding