XIAP Antikörper (AA 268-426)

Produktnummer ABIN968163

Dieses Anti-XIAP-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von XIAP in WB, IHC, IF und IP. Geeignet für Human, Maus, Ratte und Frosch. Dieses Primary Antibody wurde in 6+ Publikationen zitiert.

Kurzübersicht für XIAP Antikörper (AA 268-426) (ABIN968163)

Target: XIAP (X-Linked Inhibitor of Apoptosis (XIAP))

Reaktivität: Human, Maus, Ratte, Frosch

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser XIAP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Klon: 48-hILP-XIAP

Produktdetails anti-XIAP Antikörper

Bindungsspezifität: AA 268-426

Kreuzreaktivität: Ratte (Rattus), Maus, Frosch

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human hILP aa. 268-426

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968537, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-XIAP Antikörper (ABIN968163)

Martin, Liu, Chen, Price, Pan, Swaby, Golden: "Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death." in: The Journal of comparative neurology, Vol. 500, Issue 1, pp. 20-46, (2006) (PubMed).

Deng, Lin, Wu: "TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO." in: Genes & development, Vol. 16, Issue 1, pp. 33-45, (2002) (PubMed).

Martins, Iaccarino, Tenev, Gschmeissner, Totty, Lemoine, Savopoulos, Gray, Creasy, Dingwall, Downward: "The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 439-44, (2002) (PubMed).

Fulda, Meyer, Debatin: "Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression." in: Cancer research, Vol. 60, Issue 14, pp. 3947-56, (2000) (PubMed).

Tamm, Kornblau, Segall, Krajewski, Welsh, Kitada, Scudiero, Tudor, Qui, Monks, Andreeff, Reed: "Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 6, Issue 5, pp. 1796-803, (2000) (PubMed).

Duckett, Nava, Gedrich, Clem, Van Dongen, Gilfillan, Shiels, Hardwick, Thompson: "A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors." in: The EMBO journal, Vol. 15, Issue 11, pp. 2685-94, (1996) (PubMed).

Details zu XIAP

Target: XIAP (X-Linked Inhibitor of Apoptosis (XIAP))

Andere Bezeichnung: hILP

Hintergrund: Apoptosis is a genetically programmed, selective process of cell death that occurs during normal cell differentiation and development of multicellular organisms. Viruses depend on the biosynthetic machinery of their host cell for the production of progeny and survival. Therefore, many viruses encode proteins that protect the cell from apoptosis. hILP (human IAP-like protein) is a human homologue of the viral IAP (Inhibitor of Apoptosis Protein). hILP is a widely expressed cytoplasmic protein of 497 amino acids with three BIR (Baculovirus IAP repeats) domains and a C-terminal RING finger domain. hILP-transfected cells are protected against the apoptotic effects of Sindbis virus infection and ICE (interleukin-1beta converting enzyme) expression. This product is sold under license from Aegera Therapeutics, Inc. This antibody is routinely tested by western blot analysis.
Synonyms: hILP

Molekulargewicht: 57 kDa

Pathways: Apoptose, Caspase Kaskade in der Apoptose, Transition Metal Ion Homeostasis