IGF1R Antikörper

Produktnummer ABIN967487

Es sind 3+ Publikationen für dieses Produkt verfügbar. Der Maus Monoklonal anti-IGF1R Antikörper wird verwendet zum Nachweis von IGF1R in Proben von Human. Er wurde validiert für FACS und FM.

Kurzübersicht für IGF1R Antikörper (ABIN967487)

Target: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IGF1R Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Fluorescence Microscopy (FM)

Klon: 1H7

Produktdetails anti-IGF1R Antikörper

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: This product is routinely tested on peripheral blood granulocytes. The histogram is an example of the expected reactivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4° C.

Referenzen für anti-IGF1R Antikörper (ABIN967487)

Kooijman, Scholtens, Rijkers, Zegers: "Differential expression of type I insulin-like growth factor receptors in different stages of human T cells." in: European journal of immunology, Vol. 25, Issue 4, pp. 931-5, (1995) (PubMed).

Li, Kato, Paz, Kasuya, Fujita-Yamaguchi: "Two new monoclonal antibodies against the alpha subunit of the human insulin-like growth factor-I receptor." in: Biochemical and biophysical research communications, Vol. 196, Issue 1, pp. 92-8, (1993) (PubMed).

Xiong, Kasuya, Li, Kato, Fujita-Yamaguchi: "Growth-stimulatory monoclonal antibodies against human insulin-like growth factor I receptor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 12, pp. 5356-60, (1992) (PubMed).

Details zu IGF1R

Target: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Andere Bezeichnung: CD221

Hintergrund: Reacts with human insulin-like growth factor-I (IGF-I) receptor alpha subunit (135 kDa). IGF-IRalpha is a glycoprotein complex composed of two extracellular alpha subunits and two transmembrane beta subunits. The transmembrane subunits play a role in tyrosine phosphorylation of several intracellular signaling proteins. IGF-IRalpha is structurally and functionally similar to insulin receptor and is expressed on a variety of human hematopoietic and non-hematopoietic cells. It mediates the effects of IGF-I and IGF-II on cellular growth. 1H7 does not cross react with human insulin receptor and it can block IGF-I or IGF-II stimulated cell growth. This antibody is routinely tested by flow cytometric analysis.
Synonyms: IGF-I Receptor alpha

Pathways: RTK Signalweg, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagie